GalNAc-T6 in the relationship with invasion ability of endometrial carcinomas and prognostic significance.

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GalNAc-T6 in the relationship with invasion ability of endometrial carcinomas and prognostic significance.

Am J Cancer Res. 2017;7(5):1188-1197

Authors: Nguyen TT, Kurita T, Koi C, Murakami M, Kagami S, Hachisuga T, Masanori H, Morimoto Y, Izumi H

Abstract
O-glycosylation in the field of carcinogenesis has been a critical topic of concern for several decades. The abnormal function of enzymes catalyzing the first step of this process, named polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) has been determined to play an important role in cancer development and metastasis. Accordingly, we investigated the expression of GalNAc-T6 in endometrial carcinoma and evaluated the relationship between invasion characteristics and the cellular level of GalNAc-T6. The results suggested that positive GalNAc-T6 expression is significantly associated with histological grade of tumors and myometrial invasion characteristic. In vitro experiments showed that the over expression of GalNAc-T6 had strong association with the decrease of endometrial cell invasiveness. Taken together, our data support the use of GalNAc-T6 as a potential indicator of good prognosis and noninvasive tumor in patients with endometrial carcinoma.

PMID: 28560066 [PubMed]

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