We read with interest the recent article in The Lancet Oncology, in which Allen M Chen and colleagues1 investigated reduced-dose radiotherapy for patients with human papillomavirus (HPV)-associated squamous-cell carcinoma of the oropharynx. Few prospective studies have specifically investigated optimum (tolerable and efficacious) reduced-dose treatment regimens for such patients. This relatively new and prospective treatment approach to oropharyngeal cancer might be potentially safer and more effective than standard radiotherapy regimens.
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