Dose de-escalation to the elective lymph nodes in head and neck cancer. Reply to Amdur et al.

We would like to thank Amdur et al. for the comments raised on our series of papers on dose de-escalation to the elective neck in head and neck cancer [1–3]. We strongly agree that the bar should be set high for studies on this matter and that investigators need to be encouraged to further clarify the role of dose de-escalation to the elective neck in head and neck cancer. However, we want to point out that we never concluded that outcome was substantially better in the 40Gy group since our paper had a non-inferiority setting.

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