Publication date: 1 June 2018
Source: Cell Stem Cell, Volume 22, Issue 6
Author(s): Michael C. Hodder, Dustin J. Flanagan, Owen J. Sansom
Stem cell dynamics define the probability of accumulating mutations within the intestinal epithelium. In this issue of Cell Stem Cell, Nicholson et al. (2018) report that human intestinal stem cell dynamics differ significantly from those of mice and establish that oncogenic mutations are more likely to expand; therefore, "normal" epithelium may carry multiple mutations.
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