Validation of AQoL-8D: a health-related quality of life questionnaire for adult patients referred for otolaryngology

xlomafota13 shared this article with you from Inoreader Validation of AQoL-8D: a health-related quality of life questionnaire for adult patients referred for otolaryngology Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Feb 25. doi: 10.1007/s00405-021-06689-6. Online ahead of print. ABSTRACT PURPOSE: The purpose of the study was to validate the AQoL-8D questionnaire in the adult population of patients referred to an otolaryngology clinic. METHODS: AQoL-8D was translated into Polish. 463 patients (age18-80 years) with otolaryngological conditions were assessed with the AQoL-8D, SF-6D, and SWLS questionnaires. We investigated the item content-relevance, factor structure by means of Confirmatory Factor Analysis, corrected item-total correlations, Cronbach's alpha, Pearson correlation of the AQoL-8D scores with results from SF-6D and from the SWLS questionnaires. Finally, ANOVA was used to test the AQoL-8D ability to group the HRQoL of patients in terms of their otolaryngological management type. RESULTS: The median score of item content-relevance was 5.0 for all AQoL-8D items. Confirmatory Factor Analysis revea led the following fit indices: Comparative Fit Index = 0.81; Tucker-Lewis Index = 0.80; and Root Mean Square Error of Approximation = 0.07. Cronbach's alpha for AQoL-8D dimensions ranged from 0.48 to 0.79. Mean item-total correlations over all dimensions, super dimensions, and the instrument overall were higher than 0.3. There was a significant Pearson correlation between the results obtained with AQoL-8D and SF-6D (r = 0.68), and with AQoL-8D and SWLS (r = 0.43). A one-way ANOVA showed a significant effect of management type on HRQoL as measured by AQoL-8D [F(4,458) = 6.12, p < 0.001] CONCLUSION: AQoL-8D provides valid and reliable measures of HRQoL in patients undergoing otolaryngological treatment. Because it is a generic questionnaire, it is possible to make general comparisons of otolaryngology outcomes with those from other subspecialties. PMID:33634318 | DOI:10.1007/s00405-021-06689-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Investigating Long-Term Brow Stabilization by Endotine-Assisted Endoscopic Brow Lift with Concomitant Upper Lid Blepharoplasty

xlomafota13 shared this article with you from Inoreader Investigating Long-Term Brow Stabilization by Endotine-Assisted Endoscopic Brow Lift with Concomitant Upper Lid Blepharoplasty Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Feb 25:3489421997653. doi: 10.1177/0003489421997653. Online ahead of print. ABSTRACT OBJECTIVE: To determine whether Endotine-assisted endoscopic brow lift with concomitant upper lid blepharoplasty provides long-term brow elevation. METHODS: Pre- and post-operative photographs from 35 patients who underwent endoscopic brow lift using Endotine Forehead 3 mm implants with concomitant upper lid blepharoplasty were measured to determine chang es in brow height with surgery and up to 55 months post-operatively. Photographs of 20 control subjects who did not undergo periorbital surgery and 11 control subjects who underwent upper blepharoplasty without brow lifting were also measured to provide a basis for comparison. Emotrics software was used to perform automated brow height measurements in order to determine elevation and longevity achieved with endoscopic brow lifting in conjunction with upper lid blepharoplasty. RESULTS: There was a statistically significant increase in brow height post-operatively, averaging 1.6 mm (P < .0001, 95% confidence interval 0.95-2.18 mm). Fifty-four percent of patients had follow-up beyond 6 months post-operatively and 40% had follow-up beyond 1 year. Elevation remained stable over time with no statistically significant change across all serial post-operative visits. There was no statistically significant difference in brow elevation based on gender or age, or between right a nd left sides. CONCLUSION: Endotine-assisted endoscopic brow lift in conjunction with upper lid blepharoplasty provides modest brow elevation and long-term brow fixation as demonstrated by stable post-operative brow height measurements for up to 55 months. PMID:33631951 | DOI:10.1177/0003489421997653 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Preclinical study testing feasibility and technical requirements for successful tele‐robotic long distance peripheral vascular intervention

xlomafota13 shared this article with you from Inoreader Preclinical study testing feasibility and technical requirements for successful tele‐robotic long distance peripheral vascular intervention Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Background Robotic‐assisted endovascular surgery enables us to perform interventions from long distances. This study evaluates the workflow and telecommunication requirements of tele‐robotic peripheral vascular interventions. Methods Ten superficial femoral artery cases were performed by the operator being 44 miles away from the interventional suite, with an endovascular robotic system, on a high‐fidelity endovascular simulator. Procedural success, technical success, fluoroscopy time, residual stenosis, contrast dose, and network delay were registered. Communication success was assessed after each procedure on a scale from 1(unacceptable) to 5(ideal). Results Procedural success and technical success were 100% and 80% respectively. The mean residual stenosis, fluoroscopy time, and contrast dose were 1.7±5.25%, 6.5±1.8 min, and 58.8±14.8 ml. The mean network latency was 38.9±3.5 ms. Median communication success scores were 4.5 (min: 4, max: 5) reported by both the operator and the bedside technician on a scale of 1 (unacceptable) to 5 (ideal). Conclusion With a stable network connection and good communication protocol, a high success rate was achieved for remote robotic‐assisted peripheral vascular intervention in an ex‐vivo model. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pembrolizumab as first-line therapy in microsatellite instability metastatic colorectal cancers

xlomafota13 shared this article with you from Inoreader Pembrolizumab as first-line therapy in microsatellite instability metastatic colorectal cancers Via Association française pour l'étude du cancer Bull Cancer. 2021 Feb 22:S0007-4551(21)00039-4. doi: 10.1016/j.bulcan.2021.01.004. Online ahead of print. NO ABSTRACT PMID:33632546 | DOI:10.1016/j.bulcan.2021.01.004 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An Unusual Retained Choanal Foreign Body: A Possible Complication of COVID-19 Testing With Nasopharyngeal Swab

xlomafota13 shared this article with you from Inoreader An Unusual Retained Choanal Foreign Body: A Possible Complication of COVID-19 Testing With Nasopharyngeal Swab Via ear nose throat Ear Nose Throat J. 2021 Feb 26:145561321993933. doi: 10.1177/0145561321993933. Online ahead of print. ABSTRACT Testing for coronavirus disease 2019 is critical in controlling the pandemic all over the world. Diagnosis of severe acute respiratory syndrome coronavirus-2 infection is based on real-time polymerase chain reaction performed on nasopharyngeal swab. If not adequately performed, the viral specimen collection can be painful and lead to complications. We present a comp lication occurred during a nasopharyngeal swab collection performed in a noncooperative patient where the plastic shaft of the swab fractured during the procedure, resulting in swab tip retention deep into the nasal cavity. The foreign body was found endoscopically, stuck between the nasal septum and the superior turbinate tail at the upper level of the left choana and removed under general anesthesia in a negative pressure operating room with the health care personnel wearing personal protective equipment. Unpleasant complications like the one described can happen when the swab is collected without the necessary knowledge of nasal anatomy or conducted inappropriately, especially in noncooperative patients. Moreover, the design of currently used viral swabs may expose to accidental rupture, with risk of foreign body retention in the nasal cavities. In such cases, diagnosis and treatment are endoscopy-guided procedures performed in an adequate setting to minimize the risk of spreadin g of the pandemic. PMID:33634718 | DOI:10.1177/0145561321993933 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Endoscope-Assisted Multilayered Repair in Oronasal Fistula

xlomafota13 shared this article with you from Inoreader Endoscope-Assisted Multilayered Repair in Oronasal Fistula Via ear nose throat Ear Nose Throat J. 2021 Feb 26:145561321997607. doi: 10.1177/0145561321997607. Online ahead of print. ABSTRACT Oronasal fistula following cleft palate repair is a considerable complication with a recurrence rate of 33% to 37% and remains a challenging problem for surgeons. Furthermore, many patients have undergone several operations and experienced scar problems and other forms of morbidity. Therefore, we report a multilayered technique for oronasal fistula closure using an endoscopic nasal inferior turbinate composite graft with a palatal advance flap. This will increase the success rate after closure of small-sized oronasal fistula surgery without complications or recurrence (IRB: 2020-1671-0001). PMID:33634719 | DOI:10.1177/0145561321997607 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

EBV Positive Lymphomatoid Granulomatosis Following Dental Extractions

xlomafota13 shared this article with you from Inoreader EBV Positive Lymphomatoid Granulomatosis Following Dental Extractions Via ear nose throat Ear Nose Throat J. 2021 Feb 26:145561321997536. doi: 10.1177/0145561321997536. Online ahead of print. ABSTRACT Epstein-Barr virus (EBV) associated lymphoproliferative disorders includes a diverse group of diagnoses, encompassing both B-cell and T-cell lineages. With EBV mucocutaneous ulcers becoming a World health Organization diagnosis in 2018, introduction of the disease entity will be beneficial to the practicing otolaryngologist. We are reporting a case of a 69-year-old male with history of rheumatoid arthritis on methotrexate, recently undergoing dental extractions, who then developed multiple oral ulcerations and bony erosions of his palate and alveolar ridge. Associated symptoms included a large 3.0 cm neck mass, splenomegaly, and pulmonary nodules. Histopathology showed EBV+ lymphomatoid granulomatosis. Upon removal of immunosuppressive agent, patient's symptoms improved with resolution of oral lesions, as well as systemic symptoms. PMID:33634720 | DOI:10.1177/0145561321997536 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The long-term effects of rapamycin-based immunosuppressive protocols on the expression of renal aquaporins 1, 2, 3 and 4 water channels in rats

xlomafota13 shared this article with you from Inoreader The long-term effects of rapamycin-based immunosuppressive protocols on the expression of renal aquaporins 1, 2, 3 and 4 water channels in rats Via Cellular and Molecular Biology Histol Histopathol. 2021 Feb 26:18321. doi: 10.14670/HH-18-321. Online ahead of print. ABSTRACT BACKGROUND: To this day, the effect of multi-drug immunosuppressive protocols on renal expression of AQPs is unknown. This study aimed to determine the influence of rapamycin-based multi-drug immunosuppressive regimens on the expression of aquaporins (AQPs) 1, 2, 3, and 4 in the rat kidney. METHODS: For 6 months, 24 male Wistar rats were administered immunosuppressants, according to the three-drug protocols used in patients after organ transplantation. The rats were divided into four groups: the control group, the TRP group (tacrolimus, rapamycin, prednisone), the CRP group (cyclosporine A, rapamycin, prednisone), and the MRP group (mycophenolate mofetil, rapamycin, prednisone). Selected red cell indices and total calcium were measured in the blood of rats and quantitative analysis of AQP1, AQP2, AQP3 and AQP4 immunoexpression in the k idneys were performed. RESULTS: In the TRP and CRP groups, a mild increase of mean corpuscular hemoglobin concentration, hematocrit and total calcium were observed. Moreover, decreased expression of AQP1-4 was found in all experimental groups, with the highest decrease in the CRP group. CONCLUSIONS: The long-term immunosuppressive treatment using multi-drug protocols decreased AQP1-4 expressions in renal tubules, possibly leading to impaired urine-concentrating ability in rat. PMID:33634832 | DOI:10.14670/HH-18-321 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Barriers to Decannulation After Double‐Stage Laryngotracheal Reconstruction

xlomafota13 shared this article with you from Inoreader Barriers to Decannulation After Double‐Stage Laryngotracheal Reconstruction Via The Laryngoscope Objectives/Hypothesis To identify any potential barriers for decannulation in children undergoing double‐staged laryngotracheal reconstruction (dsLTR) beyond the severity of disease itself. Study Design Case series with chart review. Methods We performed a retrospective chart review from 2008 to 2018 of 41 children who had undergone dsLTR as primary treatment for laryngotracheal stenosis at a stand‐alone tertiary children's hospital. We examined the effect of demographic, medical, and surgical factors on successful decannulation and time to decannulation after dsLTR. Results Of the 41 children meeting inclusion criteria who underwent dsLTR, 34 (82%) were decannulated. Age, gender, race, insurance status, medical comorbidity, and multilevel stenosis did not predict overall decannulation. Insurance status did not impact time to decannulation (P = .13, Log‐rank). Factors that increased length of time to decannulation were the use of anterior and posterior cartilage grafts (P = .001, Log‐rank), history of pulmonary disease (P = .05, Log rank), history of cardiac disease (P = .017, Log‐rank), and race/ethnicity (P = .001 Log‐rank). Conclusion In a cohort with a similar decannulation rates to previous dsLTR cohorts, we identified no demographic or medical factors that influenced overall decannulation. We did observe that pulmonary comorbidity, cardiac comorbidity, and race/ethnicity lengthens time to decannulation. Level of Evidence 4 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Usefulness of Exam Questions and Vital Signs for Predicting the Outcome of Objective Vestibular Tests

xlomafota13 shared this article with you from Inoreader Usefulness of Exam Questions and Vital Signs for Predicting the Outcome of Objective Vestibular Tests Via The Laryngoscope Objectives/Hypothesis To determine the value of standard clinic screening questions and vital signs in predicting abnormal vestibular function, indicated by standard objective diagnostic tests. Study Design Retrospective records review. Methods We reviewed electronic medical records of 150 patients seen by the neurotologists or the physician assistant they supervised, in an out‐patient tertiary care clinic, between June 2018 and March 2020, and subsequently referred for the complete objective vestibular test battery (VB). Results Of standard questions asked during the initial exam about vertigo, disequilibrium, lightheadedness and oscillopsia, only vertigo predicted an abnormal response on the VB. More males than females had abnormal VB responses, P < .05. Pulse was not related to VB score. Significantly more subjects with blood pressure in the range for stage 2 hypertension (blood pressure [BP] stage 2) had abnormal than normal results on the VB, P < .00001. Subjects with BP stage 2 had high rates of diabetes (34.2%) and hypertension (68.4%) as diagnosed by their primary care physicians or cardiologists. Conclusion Complaints of subjective vertigo and BP in the range of hypertension stage 2 are most likely to predict abnormal findings on the VB. Therefore, during an examination of a patient who comes in complaining of dizziness, two measures may be the most useful for screening: BP in the range of hypertension type 2, when BP is taken by a nurse, and a question to determine whether or not the patient has true vertigo. Level of Evidence 3. Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Arachnoid granulations bulging into the transverse sinus, sigmoid sinus, straight sinus, and confluens sinuum: a magnetic resonance imaging study

xlomafota13 shared this article with you from Inoreader Arachnoid granulations bulging into the transverse sinus, sigmoid sinus, straight sinus, and confluens sinuum: a magnetic resonance imaging study Via radiol anat Surg Radiol Anat. 2021 Feb 26. doi: 10.1007/s00276-021-02719-4. Online ahead of print. ABSTRACT PURPOSE: Few studies have explored arachnoid granulations (AGs) bulging into the cranial dural sinuses using contrast-enhanced magnetic resonance imaging (MRI). This study aimed to explore such AGs in the transverse (TS), sigmoid (SigS), and straight (StS) sinuses, and confluens sinuum (ConfS) using thin-sliced, contrast MRI. METHODS: A total of 102 patients with intact dura l sinuses underwent thin-sliced, contrast MRI in the axial, coronal, and sagittal planes. RESULTS: In 88.2%, more than one AG was identified in the TS and SigS, StS, and ConfS. In the TS, AGs were identified in 40.2% on the right side and 37.3% on the left and were frequently located in the middle and lateral thirds. In the SigS, AGs were identified on the right in 17.6% and on the left in 18.6% in the distal region. In the StS, AGs were identified in 35.3% of cases, most frequently located in the proximal third, followed by the distal third. In the ConfS, AGs were identified in 20.6% of cases. Furthermore, in 23.5%, a collection of multiple AGs of varying sizes was found in the TS. A statistical difference was not shown between the mean age of 90 patients with AGs and that of 12 patients without identifiable AGs. CONCLUSIONS: Bulging AGs may more frequently found in the TS. Thin-sliced, contrast MRI is useful for delineating AGs. PMID:33635406 | DOI:10.1007/s00276-021-02719-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.