Immunohistochemical Analysis of the Expression of Breast Markers in Basal-like Breast Carcinomas Defined as Triple Negative Cancers Expressing Keratin 5

Abstract

Estrogen and progesterone receptors are possible markers for suggesting a mammary origin of metastatic carcinoma, but are useless in cases of triple negative breast cancers (TNBC). Five other potential markers of breast origin were investigated on tissue microarrays in a series of TNBCs showing keratin 5 expression, consistent with a basal-like phenotype. GATA-3 staining was observed in 82 of 115 triple negative cases (71.3%) including 23 cases with >5% staining. Mammaglobin staining was detected in 30 cases (26.0%) including 12 with >5% staining. GCDFP-15 was seen in 23 cases (20.0%) including 9 with >5% staining. NY-BR-1 positivity was present in 7 cases (6.0%) including 3 patients with >5% staining. BCA-225 staining was observed in 74 cases (64.3%); however this latter marker lacks also specificity owing to the reported widespread staining in other malignancies. GATA-3, mammaglobin and GCDFP-15 coexpression was seen in one case (0.9%), whereas GATA-3 and mammaglobin or mammaglobin and GCDFP-15 coexpression was present in 2 and 2 cases (1.7%), respectively. Using at least 5% staining as cut-off, the expression of any of the last 4 markers was 34.7%. The expression of GATA-3, mammaglobin, GCDFP-15 and NY-BR-1 is lower in TNBC-s than in breast carcinomas in general, and this may be even lower in basal-like carcinomas. Although these markers are not fully specific, by using them, a subset of basal-like TNBC-s can be identified as of mammary origin. However, a substantial proportion will not show any staining with any of these markers.

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Intelligence artificielle appliquée à la radiothérapie

Publication date: Available online 3 May 2017
Source:Cancer/Radiothérapie
Author(s): J.-E. Bibault, A. Burgun, P. Giraud




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Hémangioendothéliome épithélioïde rachidien : à propos d’un cas

Publication date: Available online 3 May 2017
Source:Cancer/Radiothérapie
Author(s): O. Munier, B. Muckensturm, M. Fesneau, T. Wachter
L'hémangioendothéliome épithélioïde est une tumeur d'origine vasculaire, rare, classée en potentiel d'agressivité entre les hémangiomes et les angiosarcomes. L'évolution reste principalement locale mais peut également donner des métastases. Nous rapportons ici le cas d'un patient atteint d'un hémangioendothéliome épithélioïde rachidien thoracique. Apres une première exérèse, une récidive locale a nécessité une reprise chirurgicale et une radiothérapie externe. Celle-ci a été effectuée avec modulation d'intensité. Au cours de la surveillance, une deuxième localisation rachidienne inopérable a nécessité une nouvelle séquence de radiothérapie effectuée avec modulation d'intensité avec boost intégré. À 24 mois du suivi, aucun signe de progression locale ou à distance n'a été noté chez notre patient. Cette observation est suivie d'une discussion avec revue de la littérature sur les autres cas d'hémangioendothéliome épithélioïde traités par irradiation.Epithelioid hemangioendothelioma is a rare vascular tumour, with features between hemangiomas and angiosarcomas. Evolution remains mainly local but may also metastasize. Here, we report a case of a patient with a spinal epithelioid hemangioendothelioma. After a first resection, local recurrence required a new excision and external radiotherapy. It was achieved by helical TomoTherapy^® with intensity modulation. During the follow-up, a second inoperable spinal location necessitated a new sequence of radiotherapy in modulation of intensity with integrated boost. The patient was alive at 24 months of follow-up without evidence of local relapse or distance. This observation is followed by a discussion with review of the literature on other epithelioid hemangioendothelioma cases treated with radiation.



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Intelligence artificielle appliquée à la radiothérapie

Publication date: Available online 3 May 2017
Source:Cancer/Radiothérapie
Author(s): J.-E. Bibault, A. Burgun, P. Giraud




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Hémangioendothéliome épithélioïde rachidien : à propos d’un cas

Publication date: Available online 3 May 2017
Source:Cancer/Radiothérapie
Author(s): O. Munier, B. Muckensturm, M. Fesneau, T. Wachter
L'hémangioendothéliome épithélioïde est une tumeur d'origine vasculaire, rare, classée en potentiel d'agressivité entre les hémangiomes et les angiosarcomes. L'évolution reste principalement locale mais peut également donner des métastases. Nous rapportons ici le cas d'un patient atteint d'un hémangioendothéliome épithélioïde rachidien thoracique. Apres une première exérèse, une récidive locale a nécessité une reprise chirurgicale et une radiothérapie externe. Celle-ci a été effectuée avec modulation d'intensité. Au cours de la surveillance, une deuxième localisation rachidienne inopérable a nécessité une nouvelle séquence de radiothérapie effectuée avec modulation d'intensité avec boost intégré. À 24 mois du suivi, aucun signe de progression locale ou à distance n'a été noté chez notre patient. Cette observation est suivie d'une discussion avec revue de la littérature sur les autres cas d'hémangioendothéliome épithélioïde traités par irradiation.Epithelioid hemangioendothelioma is a rare vascular tumour, with features between hemangiomas and angiosarcomas. Evolution remains mainly local but may also metastasize. Here, we report a case of a patient with a spinal epithelioid hemangioendothelioma. After a first resection, local recurrence required a new excision and external radiotherapy. It was achieved by helical TomoTherapy^® with intensity modulation. During the follow-up, a second inoperable spinal location necessitated a new sequence of radiotherapy in modulation of intensity with integrated boost. The patient was alive at 24 months of follow-up without evidence of local relapse or distance. This observation is followed by a discussion with review of the literature on other epithelioid hemangioendothelioma cases treated with radiation.



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Navigating cancer using online communities: a grounded theory of survivor and family experiences

Abstract

Purpose

People affected by cancer often have unmet emotional and social support needs. Online cancer communities are a convenient channel for connecting cancer survivors, allowing them to support one another. However, it is unclear whether online community use makes a meaningful contribution to cancer survivorship, as little previous research has examined the experience of using contemporary cancer communities. We aimed to explore the experiences of visitors to online cancer communities.

Methods

Twenty-three in-depth interviews were conducted with online cancer community visitors, including cancer survivors (n = 18), family members (n = 2), and individuals who were both a survivor and family member (n = 3). Interviews were analysed using a grounded theory approach.

Results

A theory developed explaining how individuals 'navigated' the experience of cancer using online cancer communities. Online advice and information led participants on a 'journey to become informed'. Online friendships normalised survivorship and cast participants on a 'journey to recreate identity'. Participants navigated a 'journey through different worlds' as they discovered relevant and hidden communities.

Conclusions

This theory highlights virtual paths people affected by cancer can take to self-manage their experience of the disease. Online community experiences can be improved by promoting online evaluation skills and signposting visitors to bereavement support.

Implications for cancer survivors

Cancer survivors can benefit through both lurking and posting in online communities. However, individuals risk becoming distressed when they befriend individuals who may soon die. Additionally, people affected by rarer cancers can struggle to find shared experiences online and may need to look elsewhere for support.

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Navigating cancer using online communities: a grounded theory of survivor and family experiences

Abstract

Purpose

People affected by cancer often have unmet emotional and social support needs. Online cancer communities are a convenient channel for connecting cancer survivors, allowing them to support one another. However, it is unclear whether online community use makes a meaningful contribution to cancer survivorship, as little previous research has examined the experience of using contemporary cancer communities. We aimed to explore the experiences of visitors to online cancer communities.

Methods

Twenty-three in-depth interviews were conducted with online cancer community visitors, including cancer survivors (n = 18), family members (n = 2), and individuals who were both a survivor and family member (n = 3). Interviews were analysed using a grounded theory approach.

Results

A theory developed explaining how individuals 'navigated' the experience of cancer using online cancer communities. Online advice and information led participants on a 'journey to become informed'. Online friendships normalised survivorship and cast participants on a 'journey to recreate identity'. Participants navigated a 'journey through different worlds' as they discovered relevant and hidden communities.

Conclusions

This theory highlights virtual paths people affected by cancer can take to self-manage their experience of the disease. Online community experiences can be improved by promoting online evaluation skills and signposting visitors to bereavement support.

Implications for cancer survivors

Cancer survivors can benefit through both lurking and posting in online communities. However, individuals risk becoming distressed when they befriend individuals who may soon die. Additionally, people affected by rarer cancers can struggle to find shared experiences online and may need to look elsewhere for support.

http://ift.tt/2qG80YT