Impact of surgical staging on prognosis in patients with borderline ovarian tumours: A meta-analysis

Publication date: February 2016
Source:European Journal of Cancer, Volume 54
Author(s): Seung-Hyuk Shim, Soo-Nyung Kim, Phill-Seung Jung, Meari Dong, Jung Eun Kim, Sun Joo Lee
BackgroundTo quantify the effect of complete surgical staging (CSS) on prognosis in borderline ovarian tumour (BOT) patients through a meta-analysis.MethodsWe systematically reviewed published studies comparing CSS with incomplete surgical staging (ISS) in BOT patients through April 2015. End-points were recurrence and mortality rates. Study design features that possibly affected participant selection, recurrence/death detection, and manuscript publication were assessed. For pooled estimates of the effect of CSS on recurrence/death, random- or fixed-effects meta-analytical models were used after assessing cross-study heterogeneity.ResultsEighteen observational studies (CSS, 1297 patients; ISS, 1473 patients) met our search criteria. Fixed-effects model-based meta-analysis indicated a reduced recurrence risk among CSS patients (odds ratio [OR]=0.64; 95% confidence interval [CI]: 0.47–0.87, P < 0.05, I² = 25.6). However, no significant between-group difference in mortality was observed (OR = 0.98; 95% CI: 0.42–2.29, P = 0.97, I² = 0). In subgroup analysis by histology, CSS was associated with a reduced recurrence risk in 16 studies of all histologic types (OR = 0.66; 95% CI: 0.48–0.91, P < 0.05, I² = 31.9) but not in two studies of only mucinous disease (OR = 0.41; 95% CI: 0.13–1.30, P = 0.13, I² = 0). In subgroup analyses with four studies with recurrence data according to fertility-sparing surgery, no significant association was found (OR = 0.51; 95% CI: 0.18–1.43, P = 0.20, I² = 0). There was no evidence of publication bias.ConclusionsIn this meta-analysis based on observational studies, CSS appeared to significantly reduce recurrence among BOT patients. No survival impact was observed. Longer-term randomised controlled trials could verify this relationship but appear infeasible for this rare tumour.



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