How breast cancer chemotherapy increases the risk of leukaemia: Thoughts about a case of diffuse large B-cell lymphoma and leukaemia after breast cancer chemotherapy.

How breast cancer chemotherapy increases the risk of leukaemia: Thoughts about a case of diffuse large B-cell lymphoma and leukaemia after breast cancer chemotherapy.

Cancer Biol Ther. 2016 Feb 9;:0

Authors: Zhang B, Zhang X, Li M, Kong L, Deng X, Yu J

Abstract
The latest studies suggest that prophylactic chemotherapy or adjuvant chemotherapy for early stage breast cancer may increase the leukaemia risk in patients. For patients with a low risk for breast cancer recurrence, physicians who make the choice for adjuvant therapy should consider the risk of its long-term side effects. Is the occurrence of lymphatic system cancer and leukaemia after breast cancer treatment associated with chemotherapy? Can these types of leukaemia be classified as therapy-related leukaemias? We believe that there may be correlations between any diseases, butwe cannot rush to conclusions or dismiss a correlation because we understand little about the diseases themselves.In this paper, we present a case of secondary diffuse large B-cell lymphoma and leukaemia in patients after breast cancer chemotherapy, it is undeniable that this is a special event. For two distinct tumouroccurrences at different times, we cannot give a clear explanation because of thechanges in the genes that might link them together. and we hope to attract the attention of otherclinicians.

PMID: 26861804 [PubMed - as supplied by publisher]

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