The Impact of Postmastectomy and Regional Nodal Radiation after Neoadjuvant Chemotherapy for Clinically Lymph Node Positive Breast Cancer: A National Cancer Database (NCDB) Analysis

No randomized data are available to characterize the overall survival (OS) impact of postmastectomy radiation (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy for breast cancer. In a study of over 15,000 cN1 women in the NCDB, PMRT was associated with improved OS for all pathologic nodal subgroups (ypN0, ypN1, ypN2-3); no OS differences were observed with RNI.

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