Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It’s Down

Publication date: 14 March 2016
Source:Cancer Cell, Volume 29, Issue 3
Author(s): G. Aaron Hobbs, Alfred Wittinghofer, Channing J. Der
Two recent studies evaluated a small molecule that specifically binds to and inactivates the KRAS G12C mutant. The new findings argue that the perception that mutant KRAS is persistently frozen in its active GTP-bound form may not be accurate.

Teaser

Two recent studies evaluated a small molecule that specifically binds to and inactivates the KRAS G12C mutant. The new findings argue that the perception that mutant KRAS is persistently frozen in its active GTP-bound form may not be accurate.


from Cancer via ola Kala on Inoreader http://ift.tt/1pHvEDv
via IFTTT