NCI researchers have identified new therapeutic targets in a common subtype of diffuse large B-cell lymphoma (DLBCL). Drugs that hit these targets, known as SMAC mimetics, are already under clinical development, and the research team hopes to begin testing them in clinical trials of patients with DLBCL.
In a study published April 11 in Cancer Cell, the NCI researchers showed that the proteins cIAP1 and cIAP2 control the activity of a key signaling pathway in B cells that drives proliferation and survival in the ABC subtype of DLBCL (ABC DLBCL). In cell lines and animal models of the ABC subtype, they found that SMAC mimetics, which inhibit cIAP1 and cIAP2, killed cancer cells and shrank tumors.
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