Approach May Allow for Stem Cell Transplant without Radiation, Chemotherapy

In a proof-of-concept study in mice, researchers from the Stanford University School of Medicine successfully performed hematopoietic (blood) stem cell (HSC) transplants (also called bone marrow transplants) without first using radiation or chemotherapy.

Instead of these toxic conditioning regimens, which are normally used to clear existing stem cells in the bone marrow before transplantation, the researchers used two biological agents that selectively eliminated HSCs in the host mice but left other tissues and organs undamaged.

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