Pancreatic cancer cells grow by instructing neighboring cells to provide them with nutrients, a new study published online August 10 in Nature has shown.
The researchers found that when grown together in culture, cancer cells prompted cells from the tumor microenvironment to degrade their own proteins and supply the cancer cells with the resulting amino acids. This external nutrient supply led to increased metabolism and growth in the pancreatic cancer cells. In separate experiments in mice, blocking the supply of nutrients from cells in the tumor microenvironment slowed pancreatic tumor growth.
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