Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

The pathway consisting of the receptor programmed cell death 1 (PD-1; also called CD279) and its ligands, PD-L1 (B7-H1 or CD274) and PD-L2 (B7-DC or CD273), plays a vital role in the maintenance of peripheral tolerance (i.e. mechanisms that maintain the quiescence of autoreactive T cells that have…

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