Reply letter to “Texture analysis of parotid gland as a predictive factor of radiation induced xerostomia: A subset analysis”

We would like to thank Nardone and colleagues for their reply and valuable comments, and we are pleased that our findings that textural image biomarkers (IBMs), which indicate heterogeneity, significantly improved the prediction of late xerostomia [1] are confirmed by their results. Unfortunately, we can only assume that the authors also observed that more heterogeneous parotid tissue was associated with a higher risk of developing late xerostomia, as their letter does not contain information on effect sizes of the heterogeneity measures.

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