Τρίτη 9 Μαΐου 2017

Dietary intake of selected nutrients and persistence of HPV infection in men

Abstract

Human papillomavirus (HPV) infection is a common sexually transmitted disease. Although often transitory, persistent oncogenic HPV infection may progress to a precursor lesion and, if not treated, can further increase the risk of cancer. The purpose of this study was to investigate the relation between dietary intake and HPV persistent infection in men of a Brazilian cohort. The study population consisted of 1248 men from the Brazilian cohort of the HIM (HPV in Men) Study, ages 18 to 70 years, who completed a quantitative food frequency questionnaire. U Mann-Whitney test was used to assess differences in median nutrient intake of selected nutrients. The association of dietary intake and persistent HPV infection was assessed in multivariate logistic models. The prevalence of any HPV infection at baseline was 66.6%. Of 1248 participants analyzed, 1211 (97.0%) were HPV positive at one or more times during the 4 years of follow-up and 781 (62.6%) were persistently HPV positive. Men with non-persistent oncogenic HPV infections had higher median intake of retinol (p=0.008), vitamin A (p<0.001) and folate (DFE) (p=0.003), and lower median intake of energy (p=0.005) and lycopene (p=0.008) in comparison to men with persistent oncogenic infections. No significant association was found between selected nutrients and persistent oncogenic HPV infection. For non-oncogenic persistent infections, only vitamin B12 intake was significantly associated (p=0.003, test for trend). No association was observed between dietary intake and persistent oncogenic-type HPV infection; however, vitamin B12 intake was inversely associated with non-oncogenic HPV persistence. This article is protected by copyright. All rights reserved.



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