Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma

Abstract

Background: Circulating long non-coding RNAs (lncRNAs) are a new class of cancer biomarkers. However, their significance in predicting outcomes in glioblastoma patients is unclear.

Methods: We measured the levels of six known oncogenic lncRNAs -- CRNDE, GAS5, H19, HOTAIR, MALAT1 and TUG1 in serum samples from 106 patients with primary glioblastoma and analyzed their association with outcomes.

Results: High levels of HOTAIR were associated with increased likelihood of death (adjusted hazard ratio [HR] = 2.04; 95% confidence interval [CI] = 1.08−9.76), recurrence, and progression (adjusted HR = 1.82; 95% CI = 1.04−6.17). High levels of GAS5 were associated with decreased likelihood of death (adjusted HR = 0.44; 95% CI = 0.18−0.99), recurrence, and progression (adjusted HR = 0.46; 95% CI = 0.16−0.98).

Conclusion: HOTAIR and GAS5 levels could serve as reciprocal prognostic predictors of survival and disease progression in patients with glioblastoma. This article is protected by copyright. All rights reserved

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