Τρίτη 2 Ιανουαρίου 2018

Genotyping Natural Killer Immune Checkpoints to Discover Biomarkers of Response

Immune checkpoints have been a focus of immunotherapy in the recent decade. Killer cell immunoglobulin-like receptors (KIR) and their cognate human leukocyte antigen (HLA) class I ligands have evolved as checkpoints to ensure self-tolerance of natural killer cells. Both KIR and HLA genetic profiles are potential biomarkers of immunotherapy outcome. Clin Cancer Res; 24(1); 3–5. ©2017 AACR.

See related article by Erbe et al., p. 189



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