Δευτέρα 12 Φεβρουαρίου 2018

An Epigenetic Switch: From Senescent Melanocytes to Malignant Melanoma (and Back)

Publication date: 12 February 2018
Source:Cancer Cell, Volume 33, Issue 2
Author(s): Verena Wagner, Jesús Gil
Oncogene-induced senescence is an important barrier during melanomagenesis. In this issue of Cancer Cell, Yu et al. show how elevated expression of structurally unrelated H3K9 demethylases disables senescence and constitutes a liability that can be exploited to restore senescence in melanoma by pharmacological inhibition of these epigenetic regulators.

Teaser

Oncogene-induced senescence is an important barrier during melanomagenesis. In this issue of Cancer Cell, Yu et al. show how elevated expression of structurally unrelated H3K9 demethylases disables senescence and constitutes a liability that can be exploited to restore senescence in melanoma by pharmacological inhibition of these epigenetic regulators.


from Cancer via ola Kala on Inoreader http://ift.tt/2G8KGuk
via IFTTT

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου