Παρασκευή 9 Μαρτίου 2018

MRI background parenchymal enhancement, breast density and serum hormones in postmenopausal women

ABSTRACT

Background parenchymal enhancement (BPE) is the degree to which normal breast tissue enhances on contrast-enhanced magnetic resonance imaging (MRI). MRI-density is a volumetric measure of breast density that is highly correlated with mammographic density, an established breast cancer risk factor. Endogenous estrogen concentrations are positively associated with postmenopausal breast cancer risk and BPE has been shown to be sensitive to hormonal exposures. The objective of this study was to examine the relationship between BPE and MRI-density and serum hormone concentrations in postmenopausal women.

This was a study of cancer-free postmenopausal women undergoing contrast-enhanced breast MRI (N=118). At the time of MRI all women completed a self-administered questionnaire and blood samples were collected for hormone analyses. Serum concentrations of estrone (E1), estradiol (E2) and bioavailable E2 were examined by category of BPE and MRI-density.

Compared to women with 'minimal' BPE, those who had 'marked' BPE had significantly higher serum concentrations of E1, E2 and bioavailable E2 (90% increase, ptrend across all categories=0.001; 150% increase, ptrend=0.001; and 158% increase, ptrend=0.001 respectively). These associations were only affected to a minor extent by adjustment for BMI and other variables. After adjustment for BMI, no significant associations between MRI-density and serum E1, E2 and bioavailable E2 were observed.

Serum estrogen concentrations were significantly positively associated with BPE. This study provides further evidence of the hormone-sensitive nature of BPE, indicating a potential role for BPE as an imaging marker of endogenous and exogenous hormonal exposures in the breast. This article is protected by copyright. All rights reserved.



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