Πέμπτη 5 Απριλίου 2018

Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer

Abstract
BACKGROUND
Human epidermal growth factor receptor 2 (HER2) is an oncogenic driver, and a well-established therapeutic target in breast and gastric cancers. Using functional and genomic analyses of patient-derived xenografts, we previously showed that a subset (approximately 5%) of metastatic colorectal cancer (CRC) tumors are driven by amplification or mutation of HER2.
MATERIALS AND METHODS
This paper reviews the role of HER2 as an oncogenic driver, a prognostic and predictive biomarker, and a clinically actionable target in CRC, considering the specifics of HER2 testing in this tumor type.
RESULTS
While the role of HER2 as a biomarker for prognosis in CRC remains uncertain, its relevance as a therapeutic target has been established. Indeed, independent studies documented substantial clinical benefit in patients treated with biomarker-driven HER2-targeted therapies, with an impact on response rates and duration of response that compared favorably with immunotherapy and other examples of precision oncology.
CONCLUSION
HER2-targeted therapeutic strategies have the potential to change the treatment paradigm for a clinically relevant subgroup of metastatic CRC patients.

from Cancer via ola Kala on Inoreader https://ift.tt/2Ix9i12
via IFTTT

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου