IL12 antitumor activities are mediated by the activation of T and natural killer (NK) lymphocytes to produce IFN. Systemically, recombinant IL12 has a narrow therapeutic window that favors local delivery, for instance, by gene therapy approaches. IL12 is a powerful partner in immunotherapy combinations with checkpoint inhibitors and adoptive T-cell transfer. Clin Cancer Res; 24(12); 2716–8. ©2018 AACR.
See related article by Hu et al., p. 2920
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