Current frontline endocrine treatment options for women with hormone receptor-positive, Human Epidermal Growth Factor Receptor 2 (HER2)-negative advanced-stage breast cancer

Publication date: Available online 19 May 2018

Source: Hematology/Oncology and Stem Cell Therapy

Author(s): Hikmat Abdel-Razeq

Abstract

Despite the recent advances in breast cancer early detection and awareness, a significant portion of patients present with an advanced-stage disease and more patients will progress to stage IV despite adequate treatment of their initial early-stage disease. Hormone receptor (HR)-positive, Human Epidermal Growth Factor Receptor-2 (HER2)-negative subtype is the commonest among all breast cancer subtypes. The management of the advanced-stage disease of this subtype has evolved significantly over the past few years. The emergence of estrogen receptor down regulators (fulvestrant), mTOR-inhibitors and the recent introduction of CDK4/6 inhibitors, like palbociclib, abemaciclib and ribociclib, has resulted in a significant and a historical improvement in treatment outcomes.

In this paper, we review many of the recently reported clinical trials that led to the approval of these new drugs in the first-line settings, along with the current international guidelines.

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