Glioma Stem-like Cells Keep Their H3.3 Variant Levels at Bay

Publication date: 14 December 2015
Source:Cancer Cell, Volume 28, Issue 6
Author(s): Oren J. Becher, Eric C. Holland
Pediatric glioblastomas (GBMs) commonly harbor mutations in histone variant H3.3, while adult GBMs do not. In this issue of Cancer Cell, Gallo and colleagues demonstrate that adult GBM stem-like cells repress H3.3 expression to maintain self-renewal properties.

Teaser

Pediatric glioblastomas (GBMs) commonly harbor mutations in histone variant H3.3, while adult GBMs do not. In this issue of Cancer Cell, Gallo and colleagues demonstrate that adult GBM stem-like cells repress H3.3 expression to maintain self-renewal properties.


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