Prognostic value of tumor-infiltrating lymphocytes differs depending on histological type and smoking habit in completely resected non-small cell lung cancer

A lower number of CD8⁺ in Non AD, a higher FOXP3/CD4 ratio in smokers with AD, and a lower number of CD20⁺ in nonsmokers with AD were identified as independent worse prognostic factors in patients with resected NSCLC. Evaluating the influence of histological type and cigarette smoke on the immunological environment may lead to the establishment of individualized immunotherapy for patients with NSCLC.

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