Inherited Mutations in DNA-Repair Genes Found in Advanced Prostate Cancers

Nearly 12% of men with advanced prostate cancer have inherited mutations in genes that play a role in repairing damaged DNA, according to a new study. Inherited mutations in DNA-repair genes—including BRCA2, ATM, and CHEK2—are associated with an increased risk of several other cancers, including breast, ovarian, and pancreatic cancer. 

"This finding offers a new window into understanding how metastatic prostate cancers develop," said Peter Nelson, M.D., of the Fred Hutchinson Cancer Research Center, who co-led the study.

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