[Correspondence] Prospective radiotherapy for patients with oropharyngeal carcinoma – Authors' reply

We thank Yue Wang and Long Wu for their thoughtful comments on our recently completed clinical trial for patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma.1 As they astutely point out, de-escalation strategies for this disease can take the form of radiotherapy dose reduction or the attenuation or outright elimination of chemotherapy. A third approach, radiotherapy volume reduction, should also be mentioned. Although Wang and Wu suggest that use of dose-reduced radiotherapy alone for HPV-associated oropharyngeal squamous cell carcinoma holds promise, little data currently exist to support such a strategy.

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