FOXP2 promotes tumor proliferation and metastasis by targeting GRP78 in triple-negative breast cancer.

Related Articles

FOXP2 promotes tumor proliferation and metastasis by targeting GRP78 in triple-negative breast cancer.

Curr Cancer Drug Targets. 2018 Jan 30;:

Authors: Wu J, Liu P, Tang H, Shuang Z, Qiu Q, Song C, Liu L, Xie X, Xiao X

Abstract
The forkhead box (FOX) proteins constitute a superfamily of evolutionarily conserved transcriptional regulators with critical roles in various biological processes, including tumor development and progression. FOXP2, a member of the forkhead box P (FOXP) family, has been reported to be important in breast cancer pathogenesis and the regulation of breast cancer metastasis. However, its exact mechanisms and pathways remain unclear. This study therefore investigated the regulatory effects of FOXP2 on tumor proliferation and metastasis in triple-negative breast cancer (TNBC) and its underlying molecular mechanisms. FOXP2 was found to be highly expressed in TNBC cell lines and tissues. FOXP2 knockdown attenuated the growth and inva-siveness of TNBC cells in vitro as well as tumor progression and metastasis in vivo. Moreover, inhibition of FOXP2 downregulated the expression of glu-cose-regulated protein of molecular mass 78 (GRP78) in TNBC cells and mouse xenograft models. Correlation analysis showed that GRP78 expres-sion was positively associated with FOXP2 expression in TNBC cells. These results indicate that FOXP2 plays a crucial role in TNBC, partly via modulat-ing GRP78, and could act as a potential target for TNBC treatment.

PMID: 29484998 [PubMed - as supplied by publisher]

from Cancer via ola Kala on Inoreader http://ift.tt/2oz6s3k
via IFTTT