Cancers, Vol. 10, Pages 198: Oncolytic Viruses for Multiple Myeloma Therapy

Cancers, Vol. 10, Pages 198: Oncolytic Viruses for Multiple Myeloma Therapy

Cancers doi: 10.3390/cancers10060198

Authors: Christine M. Calton Kevin R. Kelly Faiz Anwer Jennifer S. Carew Steffan T. Nawrocki

Although recent treatment advances have improved outcomes for patients with multiple myeloma (MM), the disease frequently becomes refractory to current therapies. MM thus remains incurable for most patients and new therapies are urgently needed. Oncolytic viruses are a promising new class of therapeutics that provide tumor-targeted therapy by specifically infecting and replicating within cancerous cells. Oncolytic therapy yields results from both direct killing of malignant cells and induction of an anti-tumor immune response. In this review, we will describe oncolytic viruses that are being tested for MM therapy with a focus on those agents that have advanced into clinical trials.

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