Nature Communications, Published online: 29 July 2020; doi:10.1038/s41467-020-17453-5Parallelized analysis in clinical genomics can lead to sample or data mislabelling, and could have serious downstream consequences. Here the authors present a tool to quantify sample genetic relatedness and detect such mistakes, and apply it to thousands of datasets from the ENCODE consortium.
Wed Jul 29, 2020 03:00
Nature Communications, Published online: 29 July 2020; doi:10.1038/s41467-020-17583-wCement plays a dual role in the carbon cycle like a sponge. Here, the authors employ a dynamic model to quantify such sponge effect and concluded that deep decarbonization of the global cement cycle will require radical technology advancements and widespread deployment of material efficiency measures.
Wed Jul 29, 2020 03:00
Nature Communications, Published online: 29 July 2020; doi:10.1038/s41467-020-17580-zOrganocatalysis has become a major pillar of (asymmetric) catalysis. Here, the authors discuss recent trends in organocatalytic activation modes for challenging stereoselective transformations and the emerging integration with other fields, such as photoredox catalysis and electrosynthesis.
Wed Jul 29, 2020 03:00
Nature Communications, Published online: 29 July 2020; doi:10.1038/s41467-020-17521-wBrain organoids are important tools to study early development and disease but little is known of their network activity and plasticity. Here the authors generate iPSC-derived neuronal organoids that display early network formation and maturation with evidence for a GABA polarity switch and long-term potentiation.
Wed Jul 29, 2020 03:00
Nature Communications, Published online: 29 July 2020; doi:10.1038/s41467-020-17559-wIn quantum metrology (as well as computing) it is not easy to pinpoint the specific source of quantum advantage. Here, the authors reveal a link between postselection and the unusually high rates of information per final measurement in general quantum parameter-estimation scenarios.
Wed Jul 29, 2020 03:00
Nature Communications, Published online: 29 July 2020; doi:10.1038/s41467-020-17302-5Existing plant pan-genomic studies usually report considerable intraspecific whole gene presence-absence variation. Here, the authors use pan-genomic approach to reveal gradual polyploid genome evolution by analyzing of Brachypodium hybridum and its diploid progenitors.
Wed Jul 29, 2020 03:00
Nature Communications, Published online: 29 July 2020; doi:10.1038/s41467-020-17592-9The use of one dimensional devices in nanomechanical mass spectrometry leads to a trade-off between analysis time and resolution. Here, the authors report single-particle mass spectrometry using integrated optomechanical resonators, impervious to particle position, stiffness or shape.
Wed Jul 29, 2020 03:00
Nature Communications, Published online: 29 July 2020; doi:10.1038/s41467-020-17552-3A platform for systemic therapeutic transgene expression independent of patient mutations needs a safe and highly transcribed locus. Here the authors ex vivo edit HPSCs using CRISPR-Cas9 to integrate transgenes under the α-globin promoter to achieve erythroid specific expression.
Wed Jul 29, 2020 03:00
Nature Communications, Published online: 29 July 2020; doi:10.1038/s41467-020-17539-0As investment in urban conservation grows, researchers must balance the needs of residents and conservation targets. We discuss some of the challenges we have encountered and the importance of taking a transdisciplinary approach informed by design and social knowledge.
Wed Jul 29, 2020 03:00
Wed Jul 29, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου