Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage

Publication date: 11 July 2016
Source:Cancer Cell, Volume 30, Issue 1
Author(s): Gauri Deb, Tim C.P. Somervaille
E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia.

Teaser

E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia.


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