Modeling the Epigenetic Chain Reaction Downstream of DNMT3AR882H

Publication date: 11 July 2016
Source:Cancer Cell, Volume 30, Issue 1
Author(s): Tim D.D. Somerville, Christopher R. Vakoc
In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3A^R882H/NRAS^G12D acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound enhancers to initiate disease. The authors also reveal a chemical strategy to interrupt this process.

Teaser

In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3A^R882H/NRAS^G12D acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound enhancers to initiate disease. The authors also reveal a chemical strategy to interrupt this process.


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