[Correspondence] Do cytogenetics of acute lymphoblastic leukaemia blasts affect required duration and intensity of maintenance therapy?

In The Lancet Oncology, Stine Nielsen and colleagues1 describe the importance of achievement of optimal concentrations of DNA-incorporated thioguanine nucleotides (DNA-TGN; a main cytotoxic metabolite of 6-mercaptopurine) during acute lymphoblastic leukaemia maintenance therapy, by showing a linear association of DNA-TGN concentration and relapse risk. The authors conclude that measurement of DNA-TGN concentration might provide a new strategy to improve dose adjustment in maintenance therapy.

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