[Correspondence] Genetics of gallbladder cancer

Sharayu Mhatre and colleagues1 published the first genome-wide association study (GWAS) on gallbladder cancer and found a strong, replicated association at chromosome 7q21.12, which harbours ATP binding cassette subfamily B genes ABCB1 and ABCB4. The authors additionally estimated the combined heritability of the GWAS data using the Genome-Wide Complex Trait Analysis tool, and reported that their data explain 23% of gallbladder cancer risk variation, corresponding to a familial relative risk (FRR) of 3·15.

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