[Correspondence] Genetics of gallbladder cancer – Authors' reply

We would like to thank Kari Hemminki and colleagues for presenting empirical familial relative risk (FRR) estimates for gallbladder cancer based on the Swedish Family-Cancer Data (SFCD) providing a benchmark for comparison of heritability estimation for this rare malignancy. We do not find it surprising that the point estimate of GWAS FRR (FRR 3·15 [95% CI 1·80–5·49])1 from our study of Indian origin was higher than that from the empirical estimate in SFCD (2·47 [1·59–3·65]) in view of the difference in underlying populations and the large confidence intervals in both sets of estimates.

http://ift.tt/2szqLhz