[Clinical Picture] Checkpoint inhibitor-induced sarcoid reaction mimicking bone metastases

A 57-year-old woman with metastatic melanoma was referred to the Oncology Clinic at the Sahlgrenska University Hospital (Gothenburg, Sweden) in June, 2016. CT scan showed that she had metastases in her lungs, mediastinal and abdominal lymph nodes, spleen, and subcutaneous tissue. She started immune checkpoint inhibition with the anti-PD-1 antibody pembrolizumab (2 mg/kg given intravenously every 3 weeks). The patient's response was remarkable: a CT scan after 3 months of treatment showed that only slightly enlarged mediastinal lymph nodes remained.

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