[Correspondence] Predictive gene-expression score for follicular lymphoma

Sarah Huet and colleagues1 have successfully developed a novel prognostic score, based on the expression profile of 23 genes in high-tumour-burden follicular lymphoma. This score can identify, at the time of diagnosis, patients with an increased risk of progression when treated with first-line rituximab and chemotherapy. In their study, Huet and colleagues1 included tissue samples that were confirmed to be grade 1–3a follicular lymphoma by expert haematopathologists. However, it should be noted that follicular lymphoma is characterised by heterogeneous clinical evolution, often involving histological transformation.

https://ift.tt/2J3doCQ