Cancer Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
[Commitment of The Bulletin du Cancer and the Collège national des enseignants en cancérologie (CNEC) to publish quality papers from residents' thesis].
Bull Cancer. 2016 Mar;103(3):220
Authors: Bay JO, André T
PMID: 26970507 [PubMed - as supplied by publisher]
[On wales and men…].
Bull Cancer. 2016 Mar;103(3):219
Authors: L'Allemain G, Bay JO, Vignot S, Comité de rédaction du Bulletin du Cancer
PMID: 26970506 [PubMed - as supplied by publisher]
[Tyrosine kinase inhibitors and pregnancy: A risk to the fetus?]
Bull Cancer. 2016 Mar 8;
Authors: Jovelet C, Broutin S, Gil S, Mir O, Paci A
Abstract
The association of cancer and pregnancy is increasingly frequent. This is related, partially, to the increasingly belated age of pregnancy. The management of cancer in pregnancy is a complicated issue. The use of tyrosine kinase inhibitors (TKIs) during pregnancy remains rare and only few data are available concerning their transplacental passage. The aim of this work is to review the data described in the literature, in order to highlight the risks incurred by the fetus, associated with these TKIs' treatment. Up to 189 pregnancies of women treated with TKIs during part or throughout their pregnancy have been described. Clinical data are reassuring and would be in favor of taking the treatment in terms of the balance maternal profit versus fetal risk. These data must, nevertheless, be interpreted with caution.
PMID: 26969425 [PubMed - as supplied by publisher]
[CEA and early detection of relapse in breast cancer subtypes: Comparison with CA 15-3].
Bull Cancer. 2016 Mar 8;
Authors: Riedinger JM, Goussot V, Desmoulins I, Lorgis V, Coutant C, Beltjens F, Lizard S, Fumoleau P
Abstract
This retrospective study evaluates the interest of CEA measurement for early detection of breast cancer recurrences. Among 804 patients with invasive breast cancer, we selected 97 patients without recurrence (WR) for 5 years or more, 32 with a local recurrence (LR) and 131 with at least one distant metastasis (DM). Elevated CEA and CA 15-3 levels (>3.1 μg/L and >26 kU/L respectively) were found in 6 % and 22 % of patients with RL respectively and in 49 % and 69 % of patients with DM. Both CEA and CA 15-3 retained a significant value in predicting DM by univariate and multivariate analysis. Higher sensitivity of CEA and CA 15-3 were found in tumors with positive hormonal receptor status. CEA and CA 15-3 levels at DM were raised respectively in 23 and 65 % of the triple negative group, 58 and 75 % of the luminal, 56 and 78 % of the luminal-HER2 and 50 and 30 % of HER2-enriched group (P=0.0094 and 0.0252 respectively). The combination of CEA and CA 15-3 increased CA 15-3 sensitivity in especially luminal and HER2-enriched groups. In conclusion, elevated CA 15-3 and CEA levels at initial diagnosis of recurrence were found to be associated with hormonal receptor status and breast cancer subtypes. The combination of CEA and CA 15-3 appeared useful especially luminal and HER2-enriched groups.
PMID: 26969424 [PubMed - as supplied by publisher]
Publication date: Available online 11 March 2016
Source:Cancer/Radiothérapie
Author(s): G. Dupic, A. Bellière-Calandry
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