Phalangeal microgeodic syndrome in childhood

Abstract

Background

Phalangeal microgeodic syndrome is an uncommon benign self-limiting condition that often occurs during cold weather. The etiology and the pathogenesis of the disease remain unclear.

Objective

To report a series of children with phalangeal microgeodic syndrome.

Materials and methods

Twenty children with phalangeal microgeodic syndrome were retrospectively identified at our hospital after 2007. The clinical data, radiologic manifestation and pathologic appearance were analyzed.

Results

The average age was 10.3 years (range: 6.5–14.6 years). Twelve patients were boys. Twenty-five phalanges were affected radiographically (23 middle phalanges [92%] and 2 proximal phalanges [8%]). On radiographs, there were multiple small phalangeal lacunae in all cases. Metaphyseal rarefaction was seen in 15 phalanges, and metaphyseal transverse lucent bands were found in 7 phalanges. Epiphyseal rarefaction was seen in three phalanges. On magnetic resonance imaging (MRI), diffuse signal abnormalities of affected phalanges were observed in all cases. Multiple other phalanges and metacarpals also showed marrow edema in three cases.

Conclusion

Phalangeal microgeodes may represent bone absorption and destruction in response to exaggerated peripheral circulatory impairment following chilblain, and mainly occur in bone growth spurts.

https://ift.tt/2wnt4uU

Understanding health‐related quality of life in adult women with metastatic cancer who have dependent children

Cancer, EarlyView.


https://ift.tt/2wedQYW

Understanding health‐related quality of life in adult women with metastatic cancer who have dependent children

Cancer, EarlyView.


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Starvation tactics using natural compounds for advanced cancers: pharmacodynamics, clinical efficacy, and predictive biomarkers

Cancer Medicine, EarlyView.


https://ift.tt/2KHNhOT

Starvation tactics using natural compounds for advanced cancers: pharmacodynamics, clinical efficacy, and predictive biomarkers

Cancer Medicine, EarlyView.


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Patient-Focused Online Resources for Melanoma: Highly Variable Content and Quality

Abstract

When patients are diagnosed or concerned with the diagnosis of melanoma, they commonly use the Internet for information. We assessed the content of patient-focused websites about melanoma. We searched for "melanoma" in four search engines then assessed the first 30 websites in each search. Among included sites, we describe potentially useful content about melanoma: website quality, readability, popularity, and social media sharing. In 31 included websites, > 80% mentioned the definition and risk factors for melanoma, when to seek medical help, how to diagnose, and treatment options, and > 70% described preventive measures. However, website quality was variable: 61% of websites had disclosures, 54% were dated, 41% had a clear author, and 41% had references. Average readability ranged from 8th to 12th grade, which is above recommended reading levels for patient websites. Despite this variation and high reading levels, we identified many high-quality melanoma websites for patients.

https://ift.tt/2FOY0nk

Patient-Focused Online Resources for Melanoma: Highly Variable Content and Quality

Abstract

When patients are diagnosed or concerned with the diagnosis of melanoma, they commonly use the Internet for information. We assessed the content of patient-focused websites about melanoma. We searched for "melanoma" in four search engines then assessed the first 30 websites in each search. Among included sites, we describe potentially useful content about melanoma: website quality, readability, popularity, and social media sharing. In 31 included websites, > 80% mentioned the definition and risk factors for melanoma, when to seek medical help, how to diagnose, and treatment options, and > 70% described preventive measures. However, website quality was variable: 61% of websites had disclosures, 54% were dated, 41% had a clear author, and 41% had references. Average readability ranged from 8th to 12th grade, which is above recommended reading levels for patient websites. Despite this variation and high reading levels, we identified many high-quality melanoma websites for patients.

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Patient-Focused Online Resources for Melanoma: Highly Variable Content and Quality

Abstract

When patients are diagnosed or concerned with the diagnosis of melanoma, they commonly use the Internet for information. We assessed the content of patient-focused websites about melanoma. We searched for "melanoma" in four search engines then assessed the first 30 websites in each search. Among included sites, we describe potentially useful content about melanoma: website quality, readability, popularity, and social media sharing. In 31 included websites, > 80% mentioned the definition and risk factors for melanoma, when to seek medical help, how to diagnose, and treatment options, and > 70% described preventive measures. However, website quality was variable: 61% of websites had disclosures, 54% were dated, 41% had a clear author, and 41% had references. Average readability ranged from 8th to 12th grade, which is above recommended reading levels for patient websites. Despite this variation and high reading levels, we identified many high-quality melanoma websites for patients.

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Patient-Focused Online Resources for Melanoma: Highly Variable Content and Quality

Abstract

When patients are diagnosed or concerned with the diagnosis of melanoma, they commonly use the Internet for information. We assessed the content of patient-focused websites about melanoma. We searched for "melanoma" in four search engines then assessed the first 30 websites in each search. Among included sites, we describe potentially useful content about melanoma: website quality, readability, popularity, and social media sharing. In 31 included websites, > 80% mentioned the definition and risk factors for melanoma, when to seek medical help, how to diagnose, and treatment options, and > 70% described preventive measures. However, website quality was variable: 61% of websites had disclosures, 54% were dated, 41% had a clear author, and 41% had references. Average readability ranged from 8th to 12th grade, which is above recommended reading levels for patient websites. Despite this variation and high reading levels, we identified many high-quality melanoma websites for patients.

https://ift.tt/2FOY0nk

Tamoxifen-induced fatty liver disease in a Caucasian patient

https://ift.tt/2jB2pS8

Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review

Abstract

Aluminum (Al), a potentially neurotoxic element, provokes various adverse effects on human health such as dialysis dementia, osteomalacia, and microcytic anemia. It has been also associated with serious neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis, and Parkinsonism dementia of Guam. The "aluminum hypothesis" of AD assumes that the metal complexes can potentiate the rate of aggregation of amyloid-β (Aβ), enhancing the toxicity of this peptide, and being able of contributing to the pathogenesis of AD. It has been supported by a number of analytical, epidemiological, and neurotoxicological studies. On the other hand, melatonin (Mel) is a potent direct free radical scavenger and indirect antioxidant, which acts increasing the activity of important related antioxidant enzymes, and preventing oxidative stress and cell death of neurons exposed to Aβ-induced neurotoxicity. Therefore, Mel might be useful in the treatment of AD by reducing the Aβ generation and by inhibiting mitochondrial cell death pathways. The present review on the role of Mel in Al-related neurodegenerative disorders concludes that the protective effects of this hormone, together with its low toxicity, support the administration of Mel as a potential supplement in the treatment of neurological disorders, in which oxidative stress is involved.

https://ift.tt/2rnoeZC

Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review

Abstract

Aluminum (Al), a potentially neurotoxic element, provokes various adverse effects on human health such as dialysis dementia, osteomalacia, and microcytic anemia. It has been also associated with serious neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis, and Parkinsonism dementia of Guam. The "aluminum hypothesis" of AD assumes that the metal complexes can potentiate the rate of aggregation of amyloid-β (Aβ), enhancing the toxicity of this peptide, and being able of contributing to the pathogenesis of AD. It has been supported by a number of analytical, epidemiological, and neurotoxicological studies. On the other hand, melatonin (Mel) is a potent direct free radical scavenger and indirect antioxidant, which acts increasing the activity of important related antioxidant enzymes, and preventing oxidative stress and cell death of neurons exposed to Aβ-induced neurotoxicity. Therefore, Mel might be useful in the treatment of AD by reducing the Aβ generation and by inhibiting mitochondrial cell death pathways. The present review on the role of Mel in Al-related neurodegenerative disorders concludes that the protective effects of this hormone, together with its low toxicity, support the administration of Mel as a potential supplement in the treatment of neurological disorders, in which oxidative stress is involved.

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Continuous low-dose infusion of patupilone increases the therapeutic index in mouse and rat tumour models

Patupilone is a microtubule-targeted cytotoxic agent with clinical efficacy, but causes diarrhoea in more than 80% of patients. The efficacy and tolerability of patupilone delivered continuously by subcutaneous (s.c.) mini-pumps [(mini-pump dose (MPD)] or by intravenous bolus administration [intravenous bolus dose (IVBD)] were compared preclinically to determine whether the therapeutic index could be improved. The antiproliferative potency in vitro of patupilone was determined by measuring total cell protein. Tumours were grown s.c. in rats (A15) or nude mice (KB31, KB8511) or intracranially in nude mice (NCI-H460-Luc). Efficacy was monitored by measuring tumour volumes, bioluminescence or survival. Toxicity was monitored by body weight and/or diarrhoea. Total drug levels in blood, plasma, tissues or dialysates were quantified ex-vivo by liquid chromatography–mass spectroscopy/mass spectroscopy. Patupilone was potent in vitro with GI50s of 0.24–0.28 nmol/l and GI90s of 0.46–1.64 nmol/l. In rats, a single IVBD of patupilone dose dependently inhibited the growth of A15 tumours, but also caused dose-dependent body weight loss and diarrhoea, whereas MPD achieved similar efficacy, but no toxicity. In mice, MPD showed efficacy similar to that of IVBD against KB31 and KB8511 tumours, but with reduced toxicity. In a mouse intracranial tumour model, IVBD was more efficacious than MPD, consistent with patupilone concentrations in the brain. MPD provided constant plasma levels, whereas IVBD had very high C0/Cmin ratios of 70–280 (rat) or 8000 (mouse) over the dosing cycle. Overall, the correlation of plasma and tumour levels with response indicated that a Cave of at least GI90 led to tumour stasis. Continuous low concentrations of patupilone by MPD increased the therapeutic index in s.c. rodent tumour models compared with IVBD by maintaining efficacy, but reducing toxicity. Correspondence to Paul M. McSheehy, PhD, Basilea Pharmaceutica, Grenzacherstrasse, 487, CH-4005 Basel, Switzerland Tel: +41 796 982 694; e-mail: paul.mcsheehy@basilea.com Received January 6, 2018 Accepted April 12, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Continuous low-dose infusion of patupilone increases the therapeutic index in mouse and rat tumour models

Patupilone is a microtubule-targeted cytotoxic agent with clinical efficacy, but causes diarrhoea in more than 80% of patients. The efficacy and tolerability of patupilone delivered continuously by subcutaneous (s.c.) mini-pumps [(mini-pump dose (MPD)] or by intravenous bolus administration [intravenous bolus dose (IVBD)] were compared preclinically to determine whether the therapeutic index could be improved. The antiproliferative potency in vitro of patupilone was determined by measuring total cell protein. Tumours were grown s.c. in rats (A15) or nude mice (KB31, KB8511) or intracranially in nude mice (NCI-H460-Luc). Efficacy was monitored by measuring tumour volumes, bioluminescence or survival. Toxicity was monitored by body weight and/or diarrhoea. Total drug levels in blood, plasma, tissues or dialysates were quantified ex-vivo by liquid chromatography–mass spectroscopy/mass spectroscopy. Patupilone was potent in vitro with GI50s of 0.24–0.28 nmol/l and GI90s of 0.46–1.64 nmol/l. In rats, a single IVBD of patupilone dose dependently inhibited the growth of A15 tumours, but also caused dose-dependent body weight loss and diarrhoea, whereas MPD achieved similar efficacy, but no toxicity. In mice, MPD showed efficacy similar to that of IVBD against KB31 and KB8511 tumours, but with reduced toxicity. In a mouse intracranial tumour model, IVBD was more efficacious than MPD, consistent with patupilone concentrations in the brain. MPD provided constant plasma levels, whereas IVBD had very high C0/Cmin ratios of 70–280 (rat) or 8000 (mouse) over the dosing cycle. Overall, the correlation of plasma and tumour levels with response indicated that a Cave of at least GI90 led to tumour stasis. Continuous low concentrations of patupilone by MPD increased the therapeutic index in s.c. rodent tumour models compared with IVBD by maintaining efficacy, but reducing toxicity. Correspondence to Paul M. McSheehy, PhD, Basilea Pharmaceutica, Grenzacherstrasse, 487, CH-4005 Basel, Switzerland Tel: +41 796 982 694; e-mail: paul.mcsheehy@basilea.com Received January 6, 2018 Accepted April 12, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2HYmgoT

Complete response to orally administered melphalan in malignant pleural effusion from an occult female genital organ primary neoplasm with BRCA1/2 mutations: a case report

Definite diagnosis of metastasis from unknown primary depends on a comprehensive immunohistochemical investigation of tumor specimen. Accurate identification of the origin site usually helps a lot in choosing ...

https://ift.tt/2IiLpOk

The Denominator in Value-Based Health Care: Porter’s Hidden Costs

No abstract available

https://ift.tt/2rpxH1J

In Response

No abstract available

https://ift.tt/2HSElIM

Brown’s Atlas of Regional Anesthesia, 5th ed

No abstract available

https://ift.tt/2roRyOC

Incidence and Risk Factors for Perioperative Cardiovascular and Respiratory Adverse Events in Pediatric Patients With Congenital Heart Disease Undergoing Noncardiac Procedures

BACKGROUND: While mortality and adverse perioperative events after noncardiac surgery in children with a broad range of congenital cardiac lesions have been investigated using large multiinstitutional databases, to date single-center studies addressing adverse outcomes in children with congenital heart disease (CHD) undergoing noncardiac surgery have only included small numbers of patients with significant heart disease. The primary objective of this study was to determine the incidences of perioperative cardiovascular and respiratory events in a large cohort of patients from a single institution with a broad range of congenital cardiac lesions undergoing noncardiac procedures and to determine risk factors for these events. METHODS: We identified 3010 CHD patients presenting for noncardiac procedures in our institution over a 5-year period. We collected demographic information, including procedure performed, cardiac diagnosis, ventricular function as assessed by echocardiogram within 6 months of the procedure, and classification of CHD into 3 groups (minor, major, or severe CHD) based on residual lesion burden and cardiovascular functional status. Characteristics related to conduct of anesthesia care were also collected. The primary outcome variables for our analysis were the incidences of intraoperative cardiovascular and respiratory events. Univariable and multivariable logistic regressions were used to determine risk factors for these 2 outcomes. RESULTS: The incidence of cardiovascular events was 11.5% and of respiratory events was 4.7%. Univariate analysis and multivariable analysis demonstrated that American Society of Anesthesiologists (≥3), emergency cases, major and severe CHD, single-ventricle physiology, ventricular dysfunction, orthopedic surgery, general surgery, neurosurgery, and pulmonary procedures were associated with perioperative cardiovascular events. Respiratory events were associated with American Society of Anesthesiologists (≥4) and otolaryngology, gastrointestinal, general surgery, and maxillofacial procedures. CONCLUSIONS: Intraoperative cardiovascular events and respiratory events in patients with CHD were relatively common. While cardiovascular events were highly associated with cardiovascular status, respiratory events were not associated with cardiovascular status. Accepted for publication March 5, 2018. Funding: None. J. A. DiNardo and K. Yuki contributed equally and share senior authorship. The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/KegmMq). Reprints will not be available from the authors. Address correspondence to Koichi Yuki, MD, Department of Anesthesiology, Perioperative and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115. Address e-mail to koichi.yuki@childrens.harvard.edu. © 2018 International Anesthesia Research Society

https://ift.tt/2HSEbBa

Pediatrics and Beyond

No abstract available

https://ift.tt/2HSE5JO

In Response

No abstract available

https://ift.tt/2rqiTzO

World Health Organization-World Federation of Societies of Anaesthesiologists (WHO-WFSA) International Standards for a Safe Practice of Anesthesia

The International Standards for a Safe Practice of Anesthesia were developed on behalf of the World Federation of Societies of Anaesthesiologists (WFSA), a nonprofit organization representing anesthesiologists in 150 countries, and the World Health Organization (WHO). The recommendations have been approved by WHO and the membership of WFSA. These Standards are applicable to all anesthesia providers throughout the world. They are intended to provide guidance and assistance to anesthesia providers, their professional organizations, hospital and facility administrators, and governments for maintaining and improving the quality and safety of anesthesia care. The Standards cover professional aspects; facilities and equipment; medications and intravenous fluids; monitoring; and the conduct of anesthesia. HIGHLY RECOMMENDED standards, the functional equivalent of mandatory standards, include (amongst other things): the continuous presence of a trained and vigilant anesthesia provider; continuous monitoring of tissue oxygenation and perfusion by clinical observation and a pulse oximeter; intermittent monitoring of blood pressure; confirmation of correct placement of an endotracheal tube (if used) by auscultation and carbon dioxide detection; the use of the WHO Safe Surgery Checklist; and a system for transfer of care at the end of an anesthetic. The International Standards represent minimum standards and the goal should always be to practice to the highest possible standards, preferably exceeding the standards outlined in this document. Accepted for publication March 22, 2018. WHO ePub clearance: WHO ePub-IP-00090890-EC. This article is jointly published in the Canadian Journal of Anesthesia and Anesthesia & Analgesia. Address correspondence to Adrian W. Gelb, Department of Anesthesia & Perioperative Care, University of California San Francisco, 500 Parnassus Ave, MUE 404, San Francisco, CA 94143. Address e-mail to adrian.gelb@ucsf.edu. © 2018 International Anesthesia Research Society

https://ift.tt/2HTAmvR

Improved lung recruitment and oxygenation during mandatory ventilation with a new expiratory ventilation assistance device: A controlled interventional trial in healthy pigs

BACKGROUND In contrast to conventional mandatory ventilation, a new ventilation mode, expiratory ventilation assistance (EVA), linearises the expiratory tracheal pressure decline. OBJECTIVE We hypothesised that due to a recruiting effect, linearised expiration oxygenates better than volume controlled ventilation (VCV). We compared the EVA with VCV mode with regard to gas exchange, ventilation volumes and pressures and lung aeration in a model of peri-operative mandatory ventilation in healthy pigs. DESIGN Controlled interventional trial. SETTING Animal operating facility at a university medical centre. ANIMALS A total of 16 German Landrace hybrid pigs. INTERVENTION The lungs of anaesthetised pigs were ventilated with the EVA mode (n=9) or VCV (control, n=7) for 5 h with positive end-expiratory pressure of 5 cmH2O and tidal volume of 8 ml kg−1. The respiratory rate was adjusted for a target end-tidal CO2 of 4.7 to 6 kPa. MAIN OUTCOME MEASURES Tracheal pressure, minute volume and arterial blood gases were recorded repeatedly. Computed thoracic tomography was performed to quantify the percentages of normally and poorly aerated lung tissue. RESULTS Two animals in the EVA group were excluded due to unstable ventilation (n=1) or unstable FiO2 delivery (n=1). Mean tracheal pressure and PaO2 were higher in the EVA group compared with control (mean tracheal pressure: 11.6 ± 0.4 versus 9.0 ± 0.3 cmH2O, P  0.99). Minute volume was lower in the EVA group compared with control (5.5 ± 0.2 versus 7.0 ± 1.0 l min−1, P = 0.02) with normoventilation in both groups (PaCO2 5.4 ± 0.3 versus 5.5 ± 0.3 kPa, P > 0.99). In the EVA group, the percentage of normally aerated lung tissue was higher (81.0 ± 3.6 versus 75.8 ± 3.0%, P = 0.017) and of poorly aerated lung tissue lower (9.5 ± 3.3 versus 15.7 ± 3.5%, P = 0.002) compared with control. CONCLUSION EVA ventilation improves lung aeration via elevated mean tracheal pressure and consequently improves arterial oxygenation at unaltered positive end-expiratory pressure (PEEP) and peak inspiratory pressure (PIP). These findings suggest the EVA mode is a new approach for protective lung ventilation. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. https://ift.tt/OBJ4xP Correspondence to Johannes Schmidt, MD, Department of Anesthesiology and Critical Care, Medical Centre – University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany Tel: +49 761 270 26390; fax: +49 761 270 23280; e-mail: johannes.schmidt@uniklinik-freiburg.de Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (https://ift.tt/2ylyqmW). © 2018 European Society of Anaesthesiology

https://ift.tt/2HUTrNU

General Anesthetic Use in Fragile X Spectrum Disorders

The fragile X premutation is characterized by a repeat expansion mutation (between 55 to 200 CGG repeats) in the fragile X mental retardation 1 (FMR1) gene, which leads to RNA toxicity at the cellular level. This may cause patients with the premutation to be particularly susceptible to environmental toxins, which could manifest clinically as new or worsening ataxia and memory loss. Multiple published case reports have also suggested general anesthetics as a potential toxin leading to negative side effects when used in patients with fragile X- associated disorders. However, at this time, there have been no formal research studies regarding cellular changes or long-term clinical manifestations after general anesthetic use in this population. This review aims to highlight previous case reports regarding sequelae related to general anesthetic use in fragile X-associated disorders. New case reports related to this phenomenon are also included. Supported through NICHD grant HD036071, the MIND Institute Intellectual and Developmental Disabilities Research Center (grant U54 HD079125) and the National Center for Advancing Translational Sciences and National Institutes of Health (grant UL1 TR001860). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. R.H. has received support from Novartis, Alcobra, Neuren, and Marinus for studies in fragile X syndrome. She has also consulted with Zynerba, Fulcrum, and Ovid regarding studies in fragile X syndrome. The remaining authors have no conflicts of interest to disclose. Address correspondence to: Randi Hagerman, MD, MIND Institute, UCDMC, 2825 50th Street, Sacramento, CA 95817 (e-mail: rjhagerman@ucdavis.edu). Received August 23, 2017 Accepted April 10, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved

https://ift.tt/2I14G3H

Safety of Sodium Bicarbonate for Control of ICP (Letter)

No abstract available

https://ift.tt/2jB2t4e

Outcomes of microvascular flap reconstruction of the head and neck in patients receiving systemic immunosuppressive therapy for organ transplantation

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2rn8yov

The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2KFY78q

The association between preoperative serum interleukin‐6 levels and postoperative prognosis in patients with T2 gallbladder cancer

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2rk0B3g

Oral rehabilitation of the cancer patient: A formidable challenge

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2KECTrn

Cystic bone tumors of the foot and ankle

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2roqWgy

Vein resection during pancreaticoduodenectomy for pancreatic adenocarcinoma: Patency rates and outcomes associated with thrombosis

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2KCqBQ6

Reply to “Poorly differentiated clusters in colorectal liver metastases: Prognostic significance in synchronous and metachronous metastases”

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2roqQWe

Poorly differentiated clusters in colorectal liver metastases: Prognostic significance in synchronous and metachronous metastases

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2HVQLj2

Outcomes of microvascular flap reconstruction of the head and neck in patients receiving systemic immunosuppressive therapy for organ transplantation

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2rn8yov

The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2KFY78q

The association between preoperative serum interleukin‐6 levels and postoperative prognosis in patients with T2 gallbladder cancer

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2rk0B3g

Oral rehabilitation of the cancer patient: A formidable challenge

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2KECTrn

Cystic bone tumors of the foot and ankle

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2roqWgy

Vein resection during pancreaticoduodenectomy for pancreatic adenocarcinoma: Patency rates and outcomes associated with thrombosis

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2KCqBQ6

Reply to “Poorly differentiated clusters in colorectal liver metastases: Prognostic significance in synchronous and metachronous metastases”

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2roqQWe

Poorly differentiated clusters in colorectal liver metastases: Prognostic significance in synchronous and metachronous metastases

Journal of Surgical Oncology, EarlyView.


https://ift.tt/2HVQLj2

Outcomes of microvascular flap reconstruction of the head and neck in patients receiving systemic immunosuppressive therapy for organ transplantation

Journal of Surgical Oncology, EarlyView.


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The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center

Journal of Surgical Oncology, EarlyView.


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via IFTTT

The association between preoperative serum interleukin‐6 levels and postoperative prognosis in patients with T2 gallbladder cancer

Journal of Surgical Oncology, EarlyView.


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via IFTTT

Oral rehabilitation of the cancer patient: A formidable challenge

Journal of Surgical Oncology, EarlyView.


from Cancer via ola Kala on Inoreader https://ift.tt/2KECTrn
via IFTTT

Cystic bone tumors of the foot and ankle

Journal of Surgical Oncology, EarlyView.


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Vein resection during pancreaticoduodenectomy for pancreatic adenocarcinoma: Patency rates and outcomes associated with thrombosis

Journal of Surgical Oncology, EarlyView.


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via IFTTT

Reply to “Poorly differentiated clusters in colorectal liver metastases: Prognostic significance in synchronous and metachronous metastases”

Journal of Surgical Oncology, EarlyView.


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via IFTTT

Poorly differentiated clusters in colorectal liver metastases: Prognostic significance in synchronous and metachronous metastases

Journal of Surgical Oncology, EarlyView.


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via IFTTT

Interprofessional, psycho‐social intervention to facilitate resilience and reduce supportive care needs for patients with cancer: Results of a noncomparative, randomized phase II trial

Psycho-Oncology, EarlyView.


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via IFTTT

Psychiatric disorders among children of parents with cancer: A Swedish register‐based matched cohort study

Psycho-Oncology, EarlyView.


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Support needs of couples with hereditary breast and ovarian cancer during reproductive decision making

Psycho-Oncology, EarlyView.


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via IFTTT

Does stress increase risk of breast cancer? A 15‐year prospective study

Psycho-Oncology, EarlyView.


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Multifactorial analysis of opsoclonus‐myoclonus syndrome etiology (“Tumor” vs. “No tumor”) in a cohort of 356 US children

Pediatric Blood &Cancer, EarlyView.


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Multicenter randomized, double‐blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT

Pediatric Blood &Cancer, EarlyView.


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Chronic myeloid leukemia following treatment for bilateral retinoblastoma

Pediatric Blood &Cancer, EarlyView.


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Efficacy and safety of recombinant E. coli asparaginase in children with previously untreated acute lymphoblastic leukemia: A randomized multicenter study of the Dutch Childhood Oncology Group

Pediatric Blood &Cancer, EarlyView.


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A comparison of ketamine + midazolam to propofol for procedural sedation for lumbar puncture in pediatric oncology by nonanesthesiologists—a randomized comparative trial

Pediatric Blood &Cancer, EarlyView.


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Randomized web‐based physical activity intervention in adolescent survivors of childhood cancer

Pediatric Blood &Cancer, EarlyView.


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Successful reduced‐intensity conditioning hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria with aplastic anemia in two children

Pediatric Blood &Cancer, EarlyView.


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via IFTTT

Interprofessional, psycho‐social intervention to facilitate resilience and reduce supportive care needs for patients with cancer: Results of a noncomparative, randomized phase II trial

Psycho-Oncology, EarlyView.


https://ift.tt/2HTfPqX

Psychiatric disorders among children of parents with cancer: A Swedish register‐based matched cohort study

Psycho-Oncology, EarlyView.


https://ift.tt/2ro9Csg

Support needs of couples with hereditary breast and ovarian cancer during reproductive decision making

Psycho-Oncology, EarlyView.


https://ift.tt/2rm6kq6

Does stress increase risk of breast cancer? A 15‐year prospective study

Psycho-Oncology, EarlyView.


https://ift.tt/2jz5tyc

Multifactorial analysis of opsoclonus‐myoclonus syndrome etiology (“Tumor” vs. “No tumor”) in a cohort of 356 US children

Pediatric Blood &Cancer, EarlyView.


https://ift.tt/2jAH23g

Multicenter randomized, double‐blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT

Pediatric Blood &Cancer, EarlyView.


https://ift.tt/2FMWe69

Chronic myeloid leukemia following treatment for bilateral retinoblastoma

Pediatric Blood &Cancer, EarlyView.


https://ift.tt/2KEBZer

Efficacy and safety of recombinant E. coli asparaginase in children with previously untreated acute lymphoblastic leukemia: A randomized multicenter study of the Dutch Childhood Oncology Group

Pediatric Blood &Cancer, EarlyView.


https://ift.tt/2FO10Ab

A comparison of ketamine + midazolam to propofol for procedural sedation for lumbar puncture in pediatric oncology by nonanesthesiologists—a randomized comparative trial

Pediatric Blood &Cancer, EarlyView.


https://ift.tt/2KF1359

Randomized web‐based physical activity intervention in adolescent survivors of childhood cancer

Pediatric Blood &Cancer, EarlyView.


https://ift.tt/2FMWdz7

Successful reduced‐intensity conditioning hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria with aplastic anemia in two children

Pediatric Blood &Cancer, EarlyView.


https://ift.tt/2KCkkUy

Dairy product consumption and risk of colorectal cancer in an older mediterranean population at high cardiovascular risk

International Journal of Cancer, EarlyView.


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Pathological tumor regression grade of metastatic tumors in lymph node predicts prognosis in esophageal cancer patients

Cancer Science, EarlyView.


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via IFTTT

Dairy product consumption and risk of colorectal cancer in an older mediterranean population at high cardiovascular risk

International Journal of Cancer, EarlyView.


https://ift.tt/2wfxYtV

Pathological tumor regression grade of metastatic tumors in lymph node predicts prognosis in esophageal cancer patients

Cancer Science, EarlyView.


https://ift.tt/2FNf5xW

Characteristics and outcomes of patients with hematologic malignancies receiving chemotherapy in the intensive care unit

Cancer, EarlyView.


https://ift.tt/2rpptXg

Three‐month posttreatment prostate‐specific antigen level as a biomarker of treatment response in patients with intermediate‐risk or high‐risk prostate cancer treated with androgen deprivation therapy and radiotherapy

Cancer, EarlyView.


https://ift.tt/2HWXXLV

Erratum: Hiyoshi A, Montgomery S, Bottai M and Hovén E I. Trajectories of income and social benefits for mothers and fathers of children with cancer: A national cohort study in Sweden. Cancer. 2018;124:1492‐1500.

Cancer, EarlyView.


https://ift.tt/2roQf21

Study finds improvements in cancer survival for privately insured and medicare patients, but not others

Cancer, Volume 124, Issue 10, Page 2071-2071, May 15, 2018.


https://ift.tt/2HXKoMw

First person: John Byrd, MD

Cancer, Volume 124, Issue 10, Page 2069-2069, May 15, 2018.


https://ift.tt/2rsToOC

Patient protection and affordable care act elimination of mammogram copays has increased mammography rates

Cancer, Volume 124, Issue 10, Page 2070-2070, May 15, 2018.


https://ift.tt/2HTgOaV

Issue Information

Cancer, Volume 124, Issue 10, Page 2059-2068, May 15, 2018.


https://ift.tt/2rsTc1Q

Patient‐centered prioritization of bladder cancer research

Cancer, EarlyView.


https://ift.tt/2KExBMv

Trends in incidence and 5‐year mortality in men with newly diagnosed, metastatic prostate cancer—A population‐based analysis of 2 national cohorts

Cancer, EarlyView.


https://ift.tt/2ru5N4T

Prostate cancer screening: And the pendulum swings

Cancer, EarlyView.


https://ift.tt/2HQuGm2

Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: Recommendations for clinical practice from the French Chronic Myeloid Leukemia Study Group

Cancer, EarlyView.


https://ift.tt/2rn4p3K

Risk factors for locoregional disease recurrence after breast‐conserving therapy in patients with breast cancer treated with neoadjuvant chemotherapy: An international collaboration and individual patient meta‐analysis

Cancer, EarlyView.


https://ift.tt/2HQupj0

Early results of lower dose dasatinib (50 mg daily) as frontline therapy for newly diagnosed chronic‐phase chronic myeloid leukemia

Cancer, EarlyView.


https://ift.tt/2rpy8ZJ

The evolution of dasatinib dosage over the years and its relevance to other anticancer medications

Cancer, EarlyView.


https://ift.tt/2HQumnk

Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma

Cancer, EarlyView.


https://ift.tt/2IokXTo

Three‐month posttreatment prostate‐specific antigen level as a biomarker of treatment response in patients with intermediate‐risk or high‐risk prostate cancer treated with androgen deprivation therapy and radiotherapy

Cancer, EarlyView.


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Characteristics and outcomes of patients with hematologic malignancies receiving chemotherapy in the intensive care unit

Cancer, EarlyView.


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via IFTTT

Erratum: Hiyoshi A, Montgomery S, Bottai M and Hovén E I. Trajectories of income and social benefits for mothers and fathers of children with cancer: A national cohort study in Sweden. Cancer. 2018;124:1492‐1500.

Cancer, EarlyView.


from Cancer via ola Kala on Inoreader https://ift.tt/2roQf21
via IFTTT

Study finds improvements in cancer survival for privately insured and medicare patients, but not others

Cancer, Volume 124, Issue 10, Page 2071-2071, May 15, 2018.


from Cancer via ola Kala on Inoreader https://ift.tt/2HXKoMw
via IFTTT

First person: John Byrd, MD

Cancer, Volume 124, Issue 10, Page 2069-2069, May 15, 2018.


from Cancer via ola Kala on Inoreader https://ift.tt/2rsToOC
via IFTTT

Patient protection and affordable care act elimination of mammogram copays has increased mammography rates

Cancer, Volume 124, Issue 10, Page 2070-2070, May 15, 2018.


from Cancer via ola Kala on Inoreader https://ift.tt/2HTgOaV
via IFTTT

Issue Information

Cancer, Volume 124, Issue 10, Page 2059-2068, May 15, 2018.


from Cancer via ola Kala on Inoreader https://ift.tt/2rsTc1Q
via IFTTT

Patient‐centered prioritization of bladder cancer research

Cancer, EarlyView.


from Cancer via ola Kala on Inoreader https://ift.tt/2KExBMv
via IFTTT

Trends in incidence and 5‐year mortality in men with newly diagnosed, metastatic prostate cancer—A population‐based analysis of 2 national cohorts

Cancer, EarlyView.


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via IFTTT

Prostate cancer screening: And the pendulum swings

Cancer, EarlyView.


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via IFTTT

Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: Recommendations for clinical practice from the French Chronic Myeloid Leukemia Study Group

Cancer, EarlyView.


from Cancer via ola Kala on Inoreader https://ift.tt/2rn4p3K
via IFTTT

Risk factors for locoregional disease recurrence after breast‐conserving therapy in patients with breast cancer treated with neoadjuvant chemotherapy: An international collaboration and individual patient meta‐analysis

Cancer, EarlyView.


from Cancer via ola Kala on Inoreader https://ift.tt/2HQupj0
via IFTTT

Early results of lower dose dasatinib (50 mg daily) as frontline therapy for newly diagnosed chronic‐phase chronic myeloid leukemia

Cancer, EarlyView.


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via IFTTT

The evolution of dasatinib dosage over the years and its relevance to other anticancer medications

Cancer, EarlyView.


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via IFTTT

Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma

Cancer, EarlyView.


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Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation

Cancer Medicine, EarlyView.


https://ift.tt/2HVg3di

Long‐term oncological outcomes of local excision versus radical resection for early colorectal cancer in young patients without preoperative chemoradiotherapy: a population‐based propensity matching study

Cancer Medicine, EarlyView.


https://ift.tt/2rnwQ2j

Prognostic relevance and performance characteristics of serum IGFBP‐2 and PAPP‐A in women with breast cancer: a long‐term Danish cohort study

Cancer Medicine, EarlyView.


https://ift.tt/2HVYMAx

Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation

Cancer Medicine, EarlyView.


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Long‐term oncological outcomes of local excision versus radical resection for early colorectal cancer in young patients without preoperative chemoradiotherapy: a population‐based propensity matching study

Cancer Medicine, EarlyView.


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Prognostic relevance and performance characteristics of serum IGFBP‐2 and PAPP‐A in women with breast cancer: a long‐term Danish cohort study

Cancer Medicine, EarlyView.


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Cancers, Vol. 10, Pages 136: Electron Nuclear Dynamics Simulations of Proton Cancer Therapy Reactions: Water Radiolysis and Proton- and Electron-Induced DNA Damage in Computational Prototypes

Cancers, Vol. 10, Pages 136: Electron Nuclear Dynamics Simulations of Proton Cancer Therapy Reactions: Water Radiolysis and Proton- and Electron-Induced DNA Damage in Computational Prototypes

Cancers doi: 10.3390/cancers10050136

Authors: Erico S. Teixeira Karthik Uppulury Austin J. Privett Christopher Stopera Patrick M. McLaurin Jorge A. Morales

Proton cancer therapy (PCT) utilizes high-energy proton projectiles to obliterate cancerous tumors with low damage to healthy tissues and without the side effects of X-ray therapy. The healing action of the protons results from their damage on cancerous cell DNA. Despite established clinical use, the chemical mechanisms of PCT reactions at the molecular level remain elusive. This situation prevents a rational design of PCT that can maximize its therapeutic power and minimize its side effects. The incomplete characterization of PCT reactions is partially due to the health risks associated with experimental/clinical techniques applied to human subjects. To overcome this situation, we are conducting time-dependent and non-adiabatic computer simulations of PCT reactions with the electron nuclear dynamics (END) method. Herein, we present a review of our previous and new END research on three fundamental types of PCT reactions: water radiolysis reactions, proton-induced DNA damage and electron-induced DNA damage. These studies are performed on the computational prototypes: proton + H2O clusters, proton + DNA/RNA bases and + cytosine nucleotide, and electron + cytosine nucleotide + H2O. These simulations provide chemical mechanisms and dynamical properties of the selected PCT reactions in comparison with available experimental and alternative computational results.

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Cancers, Vol. 10, Pages 135: The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

Cancers, Vol. 10, Pages 135: The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

Cancers doi: 10.3390/cancers10050135

Authors: Eléonore Toufektchan Franck Toledo

The p53 protein has been extensively studied for its capacity to prevent proliferation of cells with a damaged genome. Surprisingly, however, our recent analysis of mice expressing a hyperactive mutant p53 that lacks the C-terminal domain revealed that increased p53 activity may alter genome maintenance. We showed that p53 downregulates genes essential for telomere metabolism, DNA repair, and centromere structure and that a sustained p53 activity leads to phenotypic traits associated with dyskeratosis congenita and Fanconi anemia. This downregulation is largely conserved in human cells, which suggests that our findings could be relevant to better understand processes involved in bone marrow failure as well as aging and tumor suppression.

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Cancers, Vol. 10, Pages 137: YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting

Cancers, Vol. 10, Pages 137: YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting

Cancers doi: 10.3390/cancers10050137

Authors: Federica Lo Sardo Sabrina Strano Giovanni Blandino

Lung cancer is the leading cause of cancer death in the world and there is no current treatment able to efficiently treat the disease as the tumor is often diagnosed at an advanced stage. Moreover, cancer cells are often resistant or acquire resistance to the treatment. Further knowledge of the mechanisms driving lung tumorigenesis, aggressiveness, metastasization, and resistance to treatments could provide new tools for detecting the disease at an earlier stage and for a better response to therapy. In this scenario, Yes Associated Protein (YAP) and Trascriptional Coactivator with PDZ-binding motif (TAZ), the final effectors of the Hippo signaling transduction pathway, are emerging as promising therapeutic targets. Here, we will discuss the most recent advances made in YAP and TAZ biology in lung cancer and, more importantly, on the newly discovered mechanisms of YAP and TAZ inhibition in lung cancer as well as their clinical implications.

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Cancers, Vol. 10, Pages 136: Electron Nuclear Dynamics Simulations of Proton Cancer Therapy Reactions: Water Radiolysis and Proton- and Electron-Induced DNA Damage in Computational Prototypes

Cancers, Vol. 10, Pages 136: Electron Nuclear Dynamics Simulations of Proton Cancer Therapy Reactions: Water Radiolysis and Proton- and Electron-Induced DNA Damage in Computational Prototypes

Cancers doi: 10.3390/cancers10050136

Authors: Erico S. Teixeira Karthik Uppulury Austin J. Privett Christopher Stopera Patrick M. McLaurin Jorge A. Morales

Proton cancer therapy (PCT) utilizes high-energy proton projectiles to obliterate cancerous tumors with low damage to healthy tissues and without the side effects of X-ray therapy. The healing action of the protons results from their damage on cancerous cell DNA. Despite established clinical use, the chemical mechanisms of PCT reactions at the molecular level remain elusive. This situation prevents a rational design of PCT that can maximize its therapeutic power and minimize its side effects. The incomplete characterization of PCT reactions is partially due to the health risks associated with experimental/clinical techniques applied to human subjects. To overcome this situation, we are conducting time-dependent and non-adiabatic computer simulations of PCT reactions with the electron nuclear dynamics (END) method. Herein, we present a review of our previous and new END research on three fundamental types of PCT reactions: water radiolysis reactions, proton-induced DNA damage and electron-induced DNA damage. These studies are performed on the computational prototypes: proton + H2O clusters, proton + DNA/RNA bases and + cytosine nucleotide, and electron + cytosine nucleotide + H2O. These simulations provide chemical mechanisms and dynamical properties of the selected PCT reactions in comparison with available experimental and alternative computational results.

https://ift.tt/2roS2VC

Cancers, Vol. 10, Pages 135: The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

Cancers, Vol. 10, Pages 135: The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

Cancers doi: 10.3390/cancers10050135

Authors: Eléonore Toufektchan Franck Toledo

The p53 protein has been extensively studied for its capacity to prevent proliferation of cells with a damaged genome. Surprisingly, however, our recent analysis of mice expressing a hyperactive mutant p53 that lacks the C-terminal domain revealed that increased p53 activity may alter genome maintenance. We showed that p53 downregulates genes essential for telomere metabolism, DNA repair, and centromere structure and that a sustained p53 activity leads to phenotypic traits associated with dyskeratosis congenita and Fanconi anemia. This downregulation is largely conserved in human cells, which suggests that our findings could be relevant to better understand processes involved in bone marrow failure as well as aging and tumor suppression.

https://ift.tt/2rnmeR0

Cancers, Vol. 10, Pages 137: YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting

Cancers, Vol. 10, Pages 137: YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting

Cancers doi: 10.3390/cancers10050137

Authors: Federica Lo Sardo Sabrina Strano Giovanni Blandino

Lung cancer is the leading cause of cancer death in the world and there is no current treatment able to efficiently treat the disease as the tumor is often diagnosed at an advanced stage. Moreover, cancer cells are often resistant or acquire resistance to the treatment. Further knowledge of the mechanisms driving lung tumorigenesis, aggressiveness, metastasization, and resistance to treatments could provide new tools for detecting the disease at an earlier stage and for a better response to therapy. In this scenario, Yes Associated Protein (YAP) and Trascriptional Coactivator with PDZ-binding motif (TAZ), the final effectors of the Hippo signaling transduction pathway, are emerging as promising therapeutic targets. Here, we will discuss the most recent advances made in YAP and TAZ biology in lung cancer and, more importantly, on the newly discovered mechanisms of YAP and TAZ inhibition in lung cancer as well as their clinical implications.

https://ift.tt/2romhvc