Perineural Invasion Correlates With Common Pathological Variables and Clinical Outcomes of Patients With Squamous Cell Carcinoma of the Vulva Treated With Primary Radical Surgery and Inguinal-femoral Lymphadenectomy

xlomafota13 shared this article with you from Inoreader Perineural Invasion Correlates With Common Pathological Variables and Clinical Outcomes of Patients With Squamous Cell Carcinoma of the Vulva Treated With Primary Radical Surgery and Inguinal-femoral Lymphadenectomy Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1051-1056. doi: 10.21873/invivo.12349. ABSTRACT BACKGROUND/AIM: The aims of the study were: i) to assess the incidence of perineural invasion (PNI) in squamous cell carcinoma of the vulva and ii) to correlate PNI with common pathological prognostic variables and clinical outcome of patients. PATIENTS AND METHODS: The hospital records of 64 patients with vulvar squamous cell carcinoma who underwent primary radical surgery were reviewed. RESULTS: PNI was significantly related to stage (p=0.038), size (p=0.038), lymph-vascular space involvement (p=0.013) and nodal status (p=0.038), but not to patient age, tumor grade and stromal invasion. Five-year disease-free survival was 30.0% in patients with PNI and 53.1% in those without PNI (p=0.018), and the corresponding 5-year overall survival was 50.0% and 77.1% (p=0.031), respectively. CONCLUSION: PNI was associated with common pathological prognos tic variables and with a poorer clinical outcome in patients with vulvar squamous cell carcinoma. PMID:33622901 | DOI:10.21873/invivo.12349 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Experience of Greece as a Model to Contain COVID-19 Infection Spread

xlomafota13 shared this article with you from Inoreader The Experience of Greece as a Model to Contain COVID-19 Infection Spread Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1285-1294. doi: 10.21873/invivo.12380. ABSTRACT The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) emerged in late 2019 and has caused a pandemic known as corona virus disease 2019 (COVID-19), responsible for the death of more than 2 million people worldwide. The outbreak of COVID-19 has posed an unprecedented threat on human lives and public safety. The aim of this review is to describe key aspects of the bio-pathology of the novel disease, and discuss aspects of its spread, as well as targeted protective strategies that can help shape the outcome of the present and future health crises. Greece is used as a model to inhibit SARS-COV-2 spread, since it is one of the countries with the lowest fatality rates among nations of the European Union (E.U.), following two consecutive waves of COVID-19 pandemic. Furthermore, niche research technological approaches and scientific recommendations that eme rged during the COVID-19 era are discussed. PMID:33622932 | DOI:10.21873/invivo.12380 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Outcome After Radiation Therapy in Canine Intracranial Meningiomas or Gliomas

xlomafota13 shared this article with you from Inoreader Outcome After Radiation Therapy in Canine Intracranial Meningiomas or Gliomas Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1117-1123. doi: 10.21873/invivo.12357. ABSTRACT AIM: To characterize a group of dogs diagnosed with meningioma or glioma treated with radiation therapy and assess the clinical impact of diagnosis and radiation protocol on survival time. PATIENTS AND METHODS: Canine patient records from a single veterinary referral hospital, between 2011 and 2015, were searched for intracranial tumour cases treated with radiation therapy, as a sole modality. Thirty-two dogs were included. RESULTS: Median survival times were 524 days [95% confidence interval (CI)=287-677] in total, 512 days (95% CI=101-682) for the glioma group and 536 days (95% CI=249-677) for the meningioma group. No significant difference in survival was detected when using a definitive or a palliative protocol (p=0.130), nor other prognostic factors were found. CONCLUSION: Our results highlight the efficacy of radiation therapy in the tre atment of canine meningioma, as well as glioma, suggesting a change in the current perception of the response of glial tumours to radiation. PMID:33622909 | DOI:10.21873/invivo.12357 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Selection of the Appropriate Control Group Is Essential in Evaluating the Cytokine Storm in COVID-19

xlomafota13 shared this article with you from Inoreader Selection of the Appropriate Control Group Is Essential in Evaluating the Cytokine Storm in COVID-19 Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1295-1298. doi: 10.21873/invivo.12381. ABSTRACT BACKGROUND/AIM: Lately, studies have reported contradicting results on the cytokine storm seen in critically-ill COVID-19 patients. Depending on the control group used, cytokines have been found to be higher, similar or even lower in COVID-19 compared to critical illnesses associated with elevated cytokine concentrations. However, most of these studies do not take into account critical illness severity. Hence, we decided to compare cytokine levels in critically-ill COVID-19 patients and critically-ill patients of a general intensive care unit (ICU), who did not have sepsis or septic shock, but had an equal disease severity. PATIENTS AND METHODS: Interleukin (IL)-6, IL-8, IL-10 and tumour necrosis factor-α (TNF-α) were measured on ICU admission in mechanically ventilated, COVID-19 (N=36) and non-COVID-19 (N=30) patients, who had not received dexamethason e, and had equal critical illness severity. Non-COVID-19 patients did not have sepsis or septic shock. RESULTS: In our case control study, circulating IL-6 and IL-10 were lower, while TNF-α and IL-8 levels were higher in critically-ill COVID-19 patients, compared to critically-ill non-COVID-19 patients. CONCLUSION: It is difficult to infer whether the cytokine storm seen in COVID-19 differs from other critical conditions. It is important to recognize that the conclusions of related studies may depend on control group selection. PMID:33622933 | DOI:10.21873/invivo.12381 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Impact of Smoking on the Survival of Patients With High-risk HPV-positive HNSCC: A Meta-analysis

xlomafota13 shared this article with you from Inoreader Impact of Smoking on the Survival of Patients With High-risk HPV-positive HNSCC: A Meta-analysis Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1017-1026. doi: 10.21873/invivo.12345. ABSTRACT BACKGROUND/AIM: High risk Human papillomavirus (hr-HPV) and smoking are independant risk factors for head and neck squamous cell carcinomas (HNSCC). While hr-HPV+ HNSCC has a better prognosis than smoking-associated HNSCC no systematic data are yet available about the combined risk. PATIENTS AND METHODS: We performed a meta-analysis to assess the overall survival of HNSCC patients relative to the hr-HPV and smoking status. A literature review up to November 2019 was conducted in PubMed and Cochrane Library using the search terms 'HPV, Smoking and HNSCC'. RESULTS: Nine out of 748 articles were included, 1,436 out of 2,080 patients were hr-HPV+ The prevalence of hr-HPV+ smokers was 36%. The meta-analysis showed a significantly better 5-year overall survival for HPV+ non-smokers compared to smokers with risk ratio of 1.94 (95% confidence intervaI=1.46-2.58). CONCLUSION: Smoking is a negative prognostic factor for overall survival in patients with hr-HPV+ HNSCC and should thus be an important part of staging and treatment. PMID:33622897 | DOI:10.21873/invivo.12345 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Colorectal Cancer Surgery During the COVID-19 Pandemic: A Single Center Experience

xlomafota13 shared this article with you from Inoreader Colorectal Cancer Surgery During the COVID-19 Pandemic: A Single Center Experience Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1299-1305. doi: 10.21873/invivo.12382. ABSTRACT BACKGROUND/AIM: A notable re-allocation of healthcare resources and specific clinical and organizational measures have been required to prevent COVID-19 infection among hospitalized patients and healthcare workers. PATIENTS AND METHODS: From March 9th to May 9th 2020 we performed colorectal cancer elective surgery on 25 patients: a pre-hospital screening was carried out in order to avoid hospitalization of patients suspected of COVID-19 infection. RESULTS: All patients (median age=76 years; range=37-88 years) were considered suitable for admission after telephone triage; the median interval between primary diagnosis and hospital admission was 23.1 days (range=1-55 days). The median hospitalization was 7.8 days (range=4-18 days). One COVID-19-associated death was reported. CONCLUSION: Our experience demonstrates that safe colorectal cancer elec tive surgery can be performed during the pandemic COVID-19. Further consensus and guidelines to prevent diffusion of pandemic diseases among hospitalized patients and healthcare workers still need to be implemented. PMID:33622934 | DOI:10.21873/invivo.12382 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Multiple Intraosseous Lipomatosis - A Case Report and a Review of the Literature

xlomafota13 shared this article with you from Inoreader Multiple Intraosseous Lipomatosis - A Case Report and a Review of the Literature Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):959-964. doi: 10.21873/invivo.12337. ABSTRACT BACKGROUND: Intraosseous lipomatosis is a rare and uncommon entity with only a few cases reported in the literature. CASE REPORT: We report a severe case where post-traumatic radiographs showed multiple cystic osseous lesions and a pathological fracture. The findings were expanded with whole-body magnetic resonance imaging (MRI), which showed multiple osseous lesions with typical MRI characteristics of intraosseous lipomas. CONCLUSION: Our case, together with very few other cases described in the literature, emphasizes that multiple intraosseous lipomatosis is an important differential diagnosis for multiple radiolucent lesions on plain radiographs. Multiple intraosseous lipomatosis can lead to pathological fractures and severe impairment of life quality. The presence of well-defined, osteolytic lesions in the bone calls for an MRI or computed tomogra phy scan. PMID:33622889 | DOI:10.21873/invivo.12337 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prognostic Evaluation of the Site of Invasion in Pathological Stage T3a Renal Cell Carcinoma

xlomafota13 shared this article with you from Inoreader Prognostic Evaluation of the Site of Invasion in Pathological Stage T3a Renal Cell Carcinoma Via In vivo (Athens, Greece) In Vivo. 2021 Mar-Apr;35(2):1083-1089. doi: 10.21873/invivo.12353. ABSTRACT BACKGROUND/AIM: To investigate the prognostic values of fat invasion (FI) and renal vein invasion (RVI) in pT3a renal cell carcinoma (RCC), as single factors or concomitant presence. PATIENTS AND METHODS: We retrospectively reviewed the data of 173 patients who underwent radical or partial nephrectomy for RCC in our Institution. RESULTS: At a median follow-up time of 48 months, patients with RVI showed significantly increased risk of disease recurrence and worse cancer-specific survival (CSS) when compared to those with FI (p=0.007, p=0.022, respectively). Having combined RVI and FI did not show inferior prognosis compared to those with RVI only. In multivariable analysis, RVI was an independent factor for disease recurrence (HR=2.06, 95% CI=1.10-3.87, p=0.024) and CSS (HR=2.46, 95% CI=1.01-6.0, p=0.048). CONCLUSION: For patients with T3a rena l tumors, RVI was associated with inferior prognosis compared to those with FI. PMID:33622905 | DOI:10.21873/invivo.12353 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

SerenoCem™ granules: A retrospective analysis of 43 patients and identification of a subset with progressive erosion

xlomafota13 shared this article with you from Inoreader Message: SerenoCem Granules™ are a pre‐set glass ionomer cement and are associated with abnormal resorption of bone adjacent to the site of implantation when used in mastoid obliteration. This was a completely new clinical situation with erosion occurring in asymptomatic patients. SerenoCem™ granules: A retrospective analysis of 43 patients and identification of a subset with progressive erosion Via Latest Issue of Clinical Otolaryngology RSS Feed View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Implications of vestibular telemetry for the management of Ménière’s Disease—Our experience with three adults

xlomafota13 shared this article with you from Inoreader Message: EUROPEAN DEVELOPMENT OF BIONICS VESTIBULAR IMPLANT FOR BILATERAL VESTIBULAR DYSFUNCTION Fact SheetReportingResults Project Information BionicVEST Grant agreement ID: 801127 Project website Opens in new window Status Ongoing project Start date 1 September 2018 End date 31 August 2022 Funded under H2020-EU.1.2.1. Overall budget € 2 899 690 EU contribution € 2 899 690 Coordinated by SERVICIO CANARIO DE LA SALUD Spain Objective Vertigo of vestibular origin has a global prevalence of 38% in the elderly and deserves special attention because of the high risk of falls and permanent functional disability, and even death. This seriously handicaps their lives, disabling them of doing routine daily activities, such as driving and even walking. The associated total costs are around 60.000 million euros in Europe. It is estimated that at least 100 million people worldwide could benefit from a vestibular implant as an effective solution to this disease. Restoring the function of the vestibular labyrinths was not possible until now. Current devices, under research, detect change in angular velocity of the cephalic movements through gyroscopes and use this information to stimulate the semicircular canals. However, they do not code vertical and horizontal accelerations, used to sense gravitational forces, keep a stand up position and restore the sense of self-position. Linear accelerations are detected by a different set of structures which are a more complex and harder to access: the saccule and utricle. This project will develop the first system to electrically reproduce linear accelerations in the otolith organ by stimulating their neural ends. The project will have three phases: Device design, fabrication and clinical trial. Therefore, the objectives will be: 1) to study, for the first time, vestibular pathways through electrical saccule-utricle stimulation; 2) to develop a vestibular response telemetry system to analyse the evoked action potential of vestibular nerve; 3) to design, manufacture and test the first vestibular prosthesis that restores the sense of linear accelerations. The main objectives are to demonstrate the safety of a vestibular implant for human, to determine its efficacy in restoring vestibular function by measuring the improvement in objective and to objectify the improvement in Quality of Life of patients. Novel Telemetry System for Closed Loop Vestibular Prosthesis Cirmirakis, D; (2013) Novel Telemetry System for Closed Loop Vestibular Prosthesis (Cirmirakis, D, Trans.). Doctoral thesis , UCL (University College London). Full text not available from this repository. Abstract Disorders of the vestibular system result in loss of body balance and a steady vision in humans and animals. The most common consequences include vertigo, oscillopsia, postural instability and blurred vision. Currently, conventional medicine cannot cure the damage or restore the function of the vestibular system. Vestibular prosthesis may assist in restoring its function using electrical stimulation, which involves delivering current pulses into the nerves innervating the semi-circular canals in the inner ear. A vestibular prosthesis contains external electronics and an implantable medical device . The system delivers modulated electrical pulses and stimulates vestibular nerves with these pulses to inform the brain about the motion. Power transfer to, and communication with the implanted device, is provided by telemetry. In biomedical implanted devices the telemetry is usually implemented by radio-frequency induction using weakly coupled coils. Using a single set of coils for simulta neous power transfer and communication creates the challenge of contradicting requirements. For high data rates the inductive link must have a wide bandwidth but power transfer requires a low bandwidth. Moreover by modulating a carrier the power transfer is degraded. This thesis describes the design, implementation and experimental evaluation of a novel telemetry system for a three-dimensional vestibular prosthesis with neural recording. The developed telemetry system uses a single pair of inductively-coupled coils to power-up the implant and maintain bi-directional communication to control its operation. It also relays raw electroneurogram (ENG) data out of the body at high speed. For inductive power control two methods are combined: a geometrical approach and a feedback loop to maintain a constant level of delivered power. The communication to the implant (downlink) is obtained by amplitude modulation while the communication from the implant to the external transmitter (uplink) us es passive phase shift modulation. On-chip humidity sensing capabilities are facilitated in the implant microelectronics to monitor hermeticity of the package. The uplink achieves the highest data speed demonstrated in the literature of available methods using a single set of coils with combined power and communication links. The developed technique can be applied to other applications including RFID. Implications of vestibular telemetry for the management of Ménière’s Disease—Our experience with three adults Via Latest Issue of Clinical Otolaryngology RSS Feed View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Comparison between Mygind and Kaiteki positions in administration of drops to the olfactory cleft

xlomafota13 shared this article with you from Inoreader Message: https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00405-015-3701-y/MediaObjects/405_2015_3701_Fig1_HTML.jpg https://authorea.com/users/344181/articles/470848-a-comparison-between-mygind-and-kaiteki-positions-in-administration-of-drops-to-the-olfactory-cleft/master/file/figures/Figure%201%20july/Figure%201%20july.png?1606681897 A Comparison between Mygind and Kaiteki positions in administration of drops to the olfactory cleft Dafna G. Milk Grace C. Khong Osman H. Çam Fernando Alfaro‐Iraheta Claire Tierney Firas Kassem Samuel C. Leong First published: 16 December 2020 https://doi.org/10.1111/coa.13690 The study was performed at the Human Anatomy Resource Center, University of Liverpool, UK Read the full text PDFPDFTOOLS SHARE Abstract Objectives Topical nasal steroids are a common treatment intervention for olfactory dysfunction. Penetration of topical treatment to the olfactory cleft (OC), such as nasal drops, is greatly dependent on the position of the head when the treatment is administered. We aimed to examine the penetrance of nasal drops to the OC in two different head positions: the Mygind (lying head back) position and the Kaiteki position. Design and Setting The specimens were firstly positioned in Mygind, and thereafter in Kaiteki positions. Nasal drops mixed with blue food dye were administered into the nostrils in each of the head position. Endoscopic videos were recorded, and two blinded observers scored the extent of olfactory cleft penetration (OCP) using a 4‐point scale (0 = none, 3 = heavy). Participants Twelve fresh‐frozen cadaver specimens. Main outcome measures Penetration of the dye into the OC. Results The mean score of nasal drops penetrance to the OC in the Mygind position was 1.34 (standard deviation, SD = 0.92), as compared to 1.76 (SD = 0.65) in the Kaiteki position. The difference in the OCP score between the two groups was not statistically significant (P > .05). Conclusion Both Mygind and Kaiteki head positions are reasonable options for patients considering topical nasal drops for olfaction impairment. The preference of one position over the other should be determined by patient's preference and comfort. Open Research Volume46, Issue2 March 2021 Pages 406-411 Related Information Metrics Article has an altmetric score of 2 Details © 2021 John Wiley & Sons Ltd Keywords anosmia nasal drops olfaction olfactory cleft Publication History Issue Online: 23 February 2021 Version of Record online: 03 January 2021 Accepted manuscript online: 16 December 2020 Manuscript accepted: 29 November 2020 Manuscript revised: 07 November 2020 Manuscript received: 18 July 2020 Download PDF Back Additional links About Wiley Online Library Privacy Policy Terms of Use Cookies Accessibility Help & Support Contact Us Opportunities Subscription Agents Advertisers & Corporate Partners Connect with Wiley The Wiley Network Wiley Press Room Copyright © 1999-2021 John Wiley & Sons, Inc. All rights reservedWiley Home Page Rhinology Published: 04 July 2015 The administration of nasal drops in the "Kaiteki" position allows for delivery of the drug to the olfactory cleft: a pilot study in healthy subjects Eri Mori, Christos Merkonidis, Mandy Cuevas, Volker Gudziol, Yoshinori Matsuwaki & Thomas Hummel European Archives of Oto-Rhino-Laryngology volume 273, pages939–943(2016)Cite this article 544 Accesses 10 Citations 1 Altmetric Metricsdetails Abstract Systemic treatment with corticosteroids shows therapeutic effects, few patients benefit from intranasal topical drug application, probably due to limited access of the drug to the olfactory epithelium. The aim of the present study was to investigate how drops distribute within the nasal cavity when the "Kaiteki" position is performed. Thirteen healthy volunteers participated. Subjects were lying on the side with the head tilted and the chin turned upward. Blue liquid was used to visualize the intranasal distribution of the nasal drops. The investigation was carried out using photo documentation thorough nasal endoscopy; the intranasal distribution of the dye was judged by two independent observers in both a decongested state and a natural state where no decongestants had been used. With regard to the main criterion of this study, using the "Kaiteki" position, nasal drops reached the olfactory cleft in 96 % of the decongested cases and 75 % of the cases who had not been decong ested. However, this difference was not statistically different. Because the "Kaiteki" maneuver is not too difficult to perform, it is more likely that topical steroids can be helpful in cases of olfactory loss. This is a preview of subscription content, access via your institution. References 1. Landis BN, Konnerth CG, Hummel T (2004) A study on the frequency of olfactory dysfunction. Laryngoscope 114:1764–1769 CAS Article PubMed Google Scholar 2. 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Lam K, Tan BK, Lavin JM, Meen E, Conley DB (2013) Comparison of nasal sprays and irrigations in the delivery of topical agents to the olfactory mucosa. Laryngoscope 123:2950–2957 Article PubMed Google Scholar 8. Miyazaki J, Matsushita H, Yamada S, Inokuchi A (2004) New method for effective instillation of nasal drops in patients with olfactory dysfunction. Pract Oto-Rhino-Laryngol 97:697–705 Article Google Scholar 9. Kubba H, Spinou E, Robertson A (2000) The effect of head position on the distribution of drops within the nose. Am J Rhinol 14:83–86 CAS Article PubMed Google Scholar 10. Benninger MS, Hadley JA, Osguthorpe JD, Marple BF, Leopold DA, Derebery MJ, Hannley M (2004) Techniques of intranasal steroid use. Otolaryngol Head Neck Surg 130:5–24 Article PubMed Google Scholar 11. Shu CH, Lee PL, Shiao AS, Chen KT, Lan MY (2012) Topical corticosteroid applied with a squirt system being more effective than with nasal spray for steroid-dependent olfactory impairment. Laryngoscope 122:747–750 CAS Article PubMed Google Scholar 12. Blomqvist EH, Lundblad L, Bergstedt H, Stjarne P (2003) Placebo-controlled, randomized, double-blind study evaluating the efficacy of fluticasone propionate nasal spray for the treatment of patients with hyposmia/anosmia. Acta Otolaryngol 123:862–868 CAS Article PubMed Google Scholar 13. Klimek L, Hummel T, Moll B, Kobal G, Mann WJ (1998) Lateralized and bilateral olfactory function in patients with chronic sinusitis compared with healthy control subjects. Laryngoscope 108:111–114 CAS Article PubMed Google Scholar 14. Kayarkar R, Clifton NJ, Woolford TJ (2002) An evaluation of the best head position for instillation of steroid nose drops. Clin Otolaryngol Allied Sci 27:18–21 CAS Article PubMed Google Scholar 15. Karagama YG, Lancaster JL, Karkanevatos A, O'Sullivan G (2001) Delivery of nasal drops to the middle meatus: which is the best head position? Rhinology 39:226–229 CAS PubMed Google Scholar 16. Wolfensberger M, Hummel T (2002) Anti-inflammatory and surgical therapy of olfactory disorders related to sino-nasal disease. Chem Senses 27:617–622 Article PubMed Google Scholar 17. Pade J, Hummel T (2008) Olfactory function following nasal surgery. Laryngoscope 118:1260–1264 Article PubMed Google Scholar 18. Vandenhende-Szymanski C, Hochet B, Chevalier D, Mortuaire G (2015) Olfactory cleft opacity and CT score are predictive factors of smell recovery after surgery in nasal polyposis. Rhinology 53:29–34 CAS PubMed Google Scholar A Comparison between Mygind and Kaiteki positions in administration of drops to the olfactory cleft Via Latest Issue of Clinical Otolaryngology RSS Feed View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.