Πέμπτη 31 Δεκεμβρίου 2020

Psychomotor development of 4-year-old deaf children with cochlear implants: Three case studies.

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Psychomotor development of 4-year-old deaf children with cochlear implants: Three case studies.

Int J Pediatr Otorhinolaryngol. 2020 Dec 16;141:110570

Authors: Ganc M, Kobosko J, Jedrzejczak WW, Kochański B, Skarzynski H

Abstract
OBJECTIVES: Hearing is one of our most important senses, and hearing ability has an enormous impact on a child's psychomotor development. Children with auditory perception disorders may show abnormal development in terms of speech, language, and communication skills, as well as other disorders involving the cognitive sphere, social-emotional interactions, and motor development. This paper describes different paths of psychomotor development in three 4-year-old children. All were born with bilateral profound sensorineural hearing loss and were implanted early on with a cochlear implant. A longitudinal study of the children's psychomotor development was done for 3 years from the time of cochlear implantation.
METHODS: We present three children with congenital, profound bilateral sensorineural hearing loss. Psychomotor development was evaluated using the Children Development Scale (CDS) and the Psychomotor Development Evaluation Cards (PDEC). The three children were: Girl A (4 years 2 months 17 days) - a user of one CI, last assessment of psychomotor development (PDEC) was 37 months after CI activation; Boy B (4 years 3 months 21 days) - a user of two CIs, last assessment of psychomotor development (PDEC) was 39 months after activation of first CI; Boy C (4 years 1 month 5 days) - user of two CIs, last assessment of psychomotor development (PDEC) was 36 months after activation of the first CI.
RESULTS: Analysis of the results from Girl A showed very poor dynamics of development from the age of 12 months, when the first CDS evaluation was performed, up to the PDEC evaluation performed at age 4 years. The CDS score of Boy B showed a very high level of psychomotor development. The PDEC evaluation performed after 39 months of using the first CI showed that the psychomotor development of Boy B was consistent with his chronological age. Boy C presented an average level of psychomotor development (compared to typically developing children) in his CDS scores in the perioperative period and then at 4, 9, and 14 months after cochlear implantation. After 24 months, his CDS scores showed a high level of psychomotor development. After 3 years of CI use, the PDEC evaluation showed that Boy C had an average score in five tested areas, a high score in the area of fine motor skills and lateralization, and a low score in knowledge and learning competencies.
CONCLUSIONS: Children with bilateral profound hearing loss can present different paths of psychomotor development. Children who receive a CI may show an age-appropriate level of psychomotor development compared to typically developing children. However, a hearing, speech, and language rehabilitation specialist responsible for the child still needs to perform regular checkups to monitor all areas of psychomotor development. Also, the effects of the deaf child's environmental determinants on psychomotor development should be studied in detail. These determinants include the parents' emotional state, the parents' involvement in the child's rehabilitation, the family's quality of life, and the presence of deaf siblings. In particular, the difficulties encountered by the mother (or father) in being the parent of a deaf child may hinder the family from receiving adequate support.

PMID: 33348125 [PubMed - as supplied by publisher]

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Carotid artery mobilization prior to pharyngeal flap inset for patients with 22q11.2 deletion syndrome.

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Carotid artery mobilization prior to pharyngeal flap inset for patients with 22q11.2 deletion syndrome.

Int J Pediatr Otorhinolaryngol. 2020 Dec 19;141:110573

Authors: Patel KR, Partain M, Ryan DP, Hersh C, Goldenberg P, Hartnick CJ

Abstract
The management of velopharyngeal insufficiency (VPI) in patients with 22q11.2 deletion syndrome (22q11DS) poses a significant clinical challenge due to presence of a large velopharyngeal gap and a relatively high rate of internal carotid artery (ICA) medialization. To our knowledge, we are the first group to have successfully managed VPI in a series of seven pediatric patients with 22q11DS with medialized ICAs via a novel surgical technique involving carotid artery mobilization followed by pharyngeal flap insertion. Thus far, we have found this technique to be reliably safe with no significant morbidity and caregivers have reported postoperative improvement in speech, swallowing and nasal regurgitation symptoms. Herein, we provide a detailed description of our novel surgical approach, including an instructional video, for correction of VPI in patients with medialized ICAs, who have previously had limited management options.

PMID: 33359933 [PubMed - as supplied by publisher]

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Factors influencing time to operating room in children presenting with post-tonsillectomy hemorrhage.

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Factors influencing time to operating room in children presenting with post-tonsillectomy hemorrhage.

Int J Pediatr Otorhinolaryngol. 2020 Dec 20;141:110581

Authors: Michel M, Preciado D, Allen S, Behzadpour H, Pestieau S, Espinel A

Abstract
OBJECTIVES: We aimed to evaluate factors associated with time to return to OR in children presenting with post-tonsillectomy hemorrhage to a tertiary children's hospital.
METHODS: Retrospective study of pediatric patients presenting to a single institution from January 2012 to January 2020, with post-tonsillectomy hemorrhage (PTH) requiring surgical intervention for control of bleeding. Correlation, univariate, and multivariate analysis were conducted.
RESULTS: Of 15,984 tonsillectomies performed at our institution during the study period, 144 required return to the OR for bleeding control, in addition to 15 other children whose tonsillectomy had been performed at an outside institution. Mean time to the OR was 119.7 min (SD 101.5) in the morning, 77.4 min (SD 60.6) in the afternoon, 55.6 min (SD 34.8) in the evening, and 49.4 min (SD 26.4) overnight (ANOVA p < 0.0001). The mean hemoglobin decline from pre-to post-tonsillectomy was 1.3 g/dl (SD 1.7). Primary hemorrhages had a mean time to OR of 62.39 min (SD 63.42) while secondary hemorrhages mean time to OR was 85.54 min (SD 76.21) (p = 0.0064). There was no significant difference in time to OR among race/ethnicity (p = 0.928), insurance status (p = 0.359), weekday (p = 0.557), surgeon seniority (p = 0.8104) or by hemoglobin drop (p = 0.2773). When controlling for ea ch of these variables, multiple linear regression showed that only time of day had significant correlation with time to OR (p = 0.0003).
CONCLUSION: At a tertiary children's hospital, patients presenting with PTH requiring revision surgery waited the longest to get to the OR in the morning versus all other times of day. These results can aid in individualization of anticipatory guidance in order to reduce morbidity and mortality from complications requiring revision in the operating room.

PMID: 33359934 [PubMed - as supplied by publisher]

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International Pediatric Otolaryngology Group (IPOG) survey: Efforts to avoid complications in home tracheostomy care.

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International Pediatric Otolaryngology Group (IPOG) survey: Efforts to avoid complications in home tracheostomy care.

Int J Pediatr Otorhinolaryngol. 2020 Dec 18;141:110563

Authors: Caloway C, Balakrishnan K, Boudewyns A, Chan KH, Cheng A, Daniel SJ, Fayoux P, Garabedian N, Hart C, Moreddu E, Muntz H, Nicollas R, Nuss R, Pransky S, Rahbar R, Russell J, Rutter M, Sidell D, Smith RJ, Soma M, Spratley J, Thompson D, Ward RF, Watters K, Wyatt M, Zalzal G, Hartnick C

Abstract
OBJECTIVE: To provide guidance for home care tracheostomy management in the pediatric population. The mission of the IPOG is to develop expertise-based recommendations for the management of pediatric otolaryngologic disorders with the goal of improving patient care.
METHODS: Survey of expert opinion by the members of the International Pediatric Otolaryngology Group (IPOG).
RESULTS: Survey results provide guidance for caregiver teaching, the reuse of tracheostomies and suction catheters while inpatient and following discharge, acceptable sterilization practices for tracheostomies, tracheitis workup and management, and outpatient follow-up practices.
CONCLUSION: This presentation of common home tracheostomy care practices are aimed at improving patient-centered care in the pediatric population.

PMID: 33360407 [PubMed - as supplied by publisher]

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Masticatory muscles electrical activity, stress and posture in preadolescents and adolescents with and without temporomandibular dysfunction.

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Masticatory muscles electrical activity, stress and posture in preadolescents and adolescents with and without temporomandibular dysfunction.

Int J Pediatr Otorhinolaryngol. 2020 Dec 15;141:110562

Authors: Miranda LS, Graciosa MD, Puel AN, Raulino de Oliveira L, Sonza A

Abstract
OBJECTIVE: To verify the difference between the masticatory muscles' electrical activity, stress signals and the posture of preadolescents and adolescents with and without temporomandibular dysfunction (TMD).
METHODS: 24 preadolescents and adolescents aged between 11 and 18 years old were divided into two groups, TMD group (TMDG) and control group (CG). All subjects were submitted to anthropometric measurements, psychological stress analysis, temporomandibular joint clinical evaluation and TMD verification; postural evaluation and masseter and temporal muscles electrical activity analysis during chewing. For statistical analysis, the Student's t-test or Mann-Whitney U test were used according to data distribution.
RESULTS: There was a significant difference between the groups for the electrical activity of the right temporal muscles (7.43% ± 2.92 vs. 11.71% ± 5.37) and left (7.70% ± 4.04 vs.11.44% ± 4.03) in the inactive period of chewing between CG and TMDG, respectively. There was no difference in stress or posture variables between groups.
CONCLUSIONS: During the inactive period of chewing, there was greater activation of the temporal muscles in the TMDG. Female gender was prevalent in TMDG. The study participants showed signs of stress, regardless of the group. The posture and TMD relationship still need to be studied.

PMID: 33360408 [PubMed - as supplied by publisher]

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What are the current practices employed by audiologists in early hearing detection

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What are the current practices employed by audiologists in early hearing detection and intervention in the South African healthcare context?

Int J Pediatr Otorhinolaryngol. 2020 Dec 24;141:110587

Authors: Khoza-Shangase K, Kanji A, Ismail F

Abstract
BACKGROUND: Universal access to early hearing detection and intervention (EHDI) forms part of the audiology community's goal. Evidence on current practices employed by South African audiologists in EHDI in order to ensure this universal access and success for children with hearing impairment is therefore required, hence this study.
METHODS: A quantitative survey research methodology with a cross-sectional design was employed. An online survey was completed by 49 qualified audiologists and dually qualified speech therapists and audiologists. Data were analysed using descriptive statistics.
RESULTS: Results identified gaps in the implementation of EHDI within the South African context. A total of 83.7% of the participants were involved in newborn hearing screening (NHS), with over half adopting the targeted screening approach instead of universal NHS services (UNHS). Capacity versus Demand challenges play a significant role in the lack of successful implementation of NHS with over 60% of the audiologists in the sample reporting that NHS is and should only be conducted by audiologists only; with minimal evidence of task shifting found. No standardised screening protocol was found, with challenges around budget allocation for EHDI revealed.
CONCLUSIONS: Although progress has been noted, a) gaps between public and private healthcare sector resources allocations and availability, b) limited contextually responsive strategic planning, as well as c) lack of translation of knowledge, policies and guidelines into practice, are glaring areas that require attention by the South African audiology community.

PMID: 33360694 [PubMed - as supplied by publisher]

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Hearing screening in neonates with hyperbilirubinemia.

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Hearing screening in neonates with hyperbilirubinemia.

Int J Pediatr Otorhinolaryngol. 2020 Dec 23;142:110591

Authors: Ezzeldin ZM, Sharaf E, Hamdy HS, Abdelwahab Selim YA

Abstract
BACKGROUND: Hyperbilirubinemia is toxic to the auditory pathways and to the central nervous system, leaving sequelae such as hearing loss and encephalopathy. The damage to the auditory system occurs primarily within the brainstem and cranial nerve VIII, and manifests clinically as auditory neuropathy spectrum disorder.
AIM: to establish the relationship that exists between hyperbilirubinemia at birth as a risk factor of neonatal hearing loss in children born in ABOU-EL-REISH hospital.
MATERIALS AND METHODS: we carried out of 60 neonates categorized into two groups: Group (A n = 30), neonates with hyperbilirubinemia; Group (B n = 30), neonates without hyperbilirubinemia.
RESULTS: Ten neonates were boys and twenty were girls from group A and eleven boys and nigh-teen girls from group B.There was significant statistical difference between group A and group B regarding ABR (P-value = 0.001) and a statistical difference regarding OAE (P-value = 0.103 in the right ear and 0.028 in the left ear). Also, our study shows the area under the curve and the diagnostic accuracy of total serum bilirubin (TSB) level for detection of hearing screening results (ABR) at a cut-off point 21 mg/dl (P-value = 0.008 and 0.009 in the right and left ears respectively.) CONCLUSIONS: Our study showed a relevant association between bilirubin levels and abnormal hearing screening results and the importance of combined screening with OAE and ABR tests.

PMID: 33360868 [PubMed - as supplied by publisher]

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Τετάρτη 30 Δεκεμβρίου 2020

Integrative Cancer Therapies

Table of Contents Alert
Integrative Cancer Therapies- Volume: 19, Number: (January-December 2020)

Research Article
Complementary and Alternative Medicine Use in Breast Cancer Patients at a Medical Center in Taiwan: A Cross-Sectional Study
Chieh-Ying ChinYung-Hsiang ChenShin-Chung WuChien-Ting LiuYun-Fang Lee, and Ming-Yen Tsai
20 Years of Integrative Cancer Therapies
Research Article
A Prospective Outcomes Pilot Evaluation of Inspire Now: A Program for People with Lung Cancer
Ellen ConteMark LegacyAthanasios PsihogiosAnne PitmanAndrea RedwayJill Hamer-Wilson, and Dugald Seely
Exercise and Cancer Treatment
Research Article
Factors Influencing Physical Activity in Cancer Patients During Oncological Treatments: A Qualitative Study
Alice AvanciniDaniela TregnagoLaura RigattiGiulia SartoriLin YangIlaria TrestiniClelia BonaiutoMichele MilellaSara Pilotto, and Massimo Lanza
Research Article
Efficacy of Chemotherapy Integrated With Traditional Korean Medicine in Patients With Metastatic Pancreatic Cancer: A Single-Center Retrospective Study
Eun Hye KimJee-Hyun YoonSung Soo YoonJee Young Lee, and Seong Woo Yoon
San Huang Decoction Targets Aurora Kinase A to Inhibit Tumor Angiogenesis in Breast Cancer
Yanlei XuCong WangXiyan ChenYongfei LiWeihe Bian, and Chang Yao
Review Article
Acupuncture for Radiation-Induced Xerostomia in Cancer Patients: A Systematic Review and Meta-Analysis
Xixiu NiTian TianDan ChenLu LiuXiao LiFengmei LiFanrong Liang, and Ling Zhao
Study Protocol
Acupuncture for Cancer Related Pain: Protocol for a Pragmatic Randomised Wait-List Controlled Trial
Qi ZhaoSuyang ZhengGeoff P. DelaneyEugene MoylanMeera R. AgarEng-Siew KohHezheng LaiYoann BirlingGeorge Shengxi ZhangKang WangYong Ma, and Xiaoshu Zhu
Research Article
Protosappanin B Exerts Anti-tumor Effects on Colon Cancer Cells via Inhibiting GOLPH3 Expression
Xue-Cong ZhengZe-Sheng ShiCheng-Zhi QiuZhong-Shi HongChun-Xiao WangHai-Bin ZhuangZhi-Chuan Chen, and Jian-Peng Pan
First Steps in the Development of an Expertise-Based Anthroposophic Complex Intervention for Oncological Treatment in Primary Care: A Qualitative Study
E. Belt-van ZoenA. M. De BruinA. S. PonsteinM. P. Ephraïm, and E. W. Baars
The Feasibility and Effects of Qigong Intervention (Mind-Body Exercise) in Cancer Patients With Insomnia: A Pilot Qualitative Study
Sara L. K. LowBirinder S. CheemaHsiewe Ying TanYoann Birling, and Xiaoshu Zhu
Cancer and the Microbiome
Research Article
Quxie Capsule Modulating Gut Microbiome and Its Association With T cell Regulation in Patients With Metastatic Colorectal Cancer: Result From a Randomized Controlled Clinical Trial
Lingyun SunYunzi YanDongmei Chen, and Yufei Yang
Exercise and Cancer Treatment
Study Protocol
Therapeutic Education and Physical Activity to Support Self-management of Cancer-related Fatigue in Hematologic Cancer Patients: Protocol of a Feasibility Randomized Controlled Trial
Monica DentiMonia Allisen AccogliStefania Costi, and Stefania Fugazzaro
Research Article
Effects of a Clinic-Based Exercise Program on Sleep Disturbance Among Cancer Survivors
Mary C. HiddeHeather J. LeachRyan J. MarkerJohn C. Peters, and W. Thomas Purcell
Review Article
A Review of Natural Therapies Potentially Relevant in Triple Negative Breast Cancer Aimed at Targeting Cancer Cell Vulnerabilities
Myfanwy Jane Webb and Craig Kukard
Research Articles
Inhibition to Epithelial-Mesenchymal Transition and Metastatic Potential In Colorectal Cancer Cell By Combination of Traditional Chinese Medicine Formulation Jiedu Sangen Decoction and PD-L1 Inhibitor
Feiyu ShanLeitao SunLeyin ZhangKaibo GuoQingying YanGuan FengYing ZhuMinhe Shen, and Shanming Ruan
Research Article
Home-Based Physical Activity in Patients With Breast Cancer: During and/or After Chemotherapy? Impact on Cardiorespiratory Fitness. A 3-Arm Randomized Controlled Trial (APAC)
François VincentElise DelucheJoëlle BonisSophie LeobonMarie-Thérèse AntoniniCaroline LavalFlorent FavardEloïse DobbelsSandrine Lavau-DenesAnaïs LabrunieFrédéric ThuillierLaurence Venat, and Nicole Tubiana-Mathieu
Pleurotus highking mushrooms potentiate antiproliferative and antimigratory activity against triple-negative breast cancer cells by suppressing Akt signaling
Md. Anwarul HaqueA. S. M. Ali RezaMst. Samima Nasrin, and Md. Atiar Rahman
Combinatorial Therapy of High Dose Vitamin C and PARP Inhibitors in DNA Repair Deficiency: A Series of 8 Patients
Mutlu Demiray
Review Article
Research Trends of Acupuncture Therapy on Cancer Over the Past Two Decades: A Bibliometric Analysis
Jing GuoLixia PeiLu ChenHao ChenDongmei GuChen XinYongjun Peng, and Jianhua Sun
Research Articles
The Effect of Peppermint (Mentha piperita) Extract on the Severity of Nausea, Vomiting and Anorexia in Patients with Breast Cancer Undergoing Chemotherapy: A Randomized Controlled Trial
Hadi JafarimaneshMehran AkbariRezvan HoseinianMahdi Zarei, and Mehdi Harorani
Ginkgo biloba Extract Attenuates Methotrexate-Induced Testicular Injury in Rats: Cross-talk Between Oxidative Stress, Inflammation, Apoptosis, and miRNA-29a Expression
Iman O. SherifLaila A. Al-Mutabagani, and Osama M. Sarhan
Exercise and Cancer Treatment
Research Article
Heart Rate Variability and Cardiovascular Adaptations Among Cancer-Survivors Following a 26-Week Exercise Intervention
Silvie GroteJeanette M. RicciSalem DehomNaomi ModesteDiadrey-Ann Sealy, and Heather P. Tarleton
Research Article
A Prospective Pilot Study Evaluating Feasibility and Preliminary Effects of Breathe Easier: A Mindfulness-based Intervention for Survivors of Lung Cancer and Their Family Members (Dyads)
Karen Kane McDonnellDavid G. GalleraniBrandi R. NewsomeOtis L. OwensJenay BeerAmanda R. Myren-BennettElizabeth ReganJames W. Hardin, and Lisa A. Webb
Feasibility of Beans/Bran Enriching Nutritional Eating For Intestinal Health & Cancer Including Activity for Longevity: A Pilot Trial to Improve Healthy Lifestyles among Individuals at High Risk for Colorectal Cancer
Heather J. LeachBridget A. BaxterMelanie N. BealeHillary V. SmithSangeeta RaoSarah Hibbs-Shipp, and Elizabeth P. Ryan
The Effect of Mindfulness-Based Stress Reduction Group Counseling on Psychological and Inflammatory Responses of the Women With Breast Cancer
Motahareh MirmahmoodiParvin MangalianAtefeh Ahmadi, and Mahlagha Dehghan
The Effect of Yoga Interventions on Cancer-Related Fatigue and Quality of Life for Women with Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meagan O'NeillDominic SamarooChristian LopezGeorge TomlinsonDaniel Santa MinaCatherine SabistonNicole Culos-Reed, and Shabbir M. H. Alibhai
A Prospective and Retrospective Clinical Controlled Observation of Chinese Herbal Decoction (SMLJ01) for Type 1 Gastric Neuroendocrine Tumors
Yingying ChenDeng HanJiqing ZhuJie ChenHaiyi HuDou DouXin WangBing YuanChao WangZhirong QiXinran ZhangJixi LiuJie Luo, and Huangying Tan
Review Article
A Narrative Review of Regional Hyperthermia: Updates From 2010 to 2019
Giammaria FiorentiniDonatella SartiCosmo Damiano GadaletaMarco BalleriniCaterina FiorentiniTommaso GarfagnoGirolamo Ranieri, and Stefano Guadagni
Research Article
Huaier Extractum Promotes Dendritic Cells Maturation and Favors them to Induce Th1 Immune Response: One of the Mechanisms Underlying Its Anti-Tumor Activity
Jun PanZhou JiangDang WuChenghui YangZhen Wang, and Jian Huang
Electronic Moxibustion for Breast Cancer-Related Lymphedema: A Pilot Clinical Trial
Kyungsun HanOjin KwonHyo-Ju ParkAe-Ran KimBoram LeeMikyung KimJoo-Hee KimChang-sup Yang, and Hwa-Seung Yoo
Fatigue, Treatment Side Effects and Rehabilitation
Research Articles
Analysis of Changes in Cancer-Related Fatigue of Breast Cancer Patients Receiving an Integrative Medicine Program
Friedemann SchadAnja ThronickePhillipp von Trott, and Shiao Li Oei
Review Article
The Effects of Acupuncture on Cancer-Related Fatigue: Updated Systematic Review and Meta-Analysis
Andrew JangChris BrownGillian LamouryMarita MorgiaFrances BoyleIsobel MarrStephen ClarkeMichael Back, and Byeongsang Oh
Research Article
Chamomile Gel versus Urea Cream to Prevent Acute Radiation Dermatitis in Head and Neck Cancer Patients: Results from a Preliminary Clinical Trial
Elaine B. FerreiraMarcia A. CiolAmanda G. de MenesesPriscila de S. M. BontempoJeanne M. Hoffman, and Paula E. D. dos Reis
Solanine Attenuated Hepatocarcinoma Migration and Invasion Induced by Acetylcholine
Liang-Tzung LinChen-Yen Choong, and Chen-Jei Tai
Human Biofield Therapy Modulates Tumor Microenvironment and Cancer Stemness in Mouse Lung Carcinoma
Peiying YangPatrea R. RheaTara ConwaySita NookalaVenkatesh HegdeMihai GageaNadim J. AjamiSean L. HarribanceJewel OchoaJagannadha K. Sastry, and Lorenzo Cohen
Review Article
Can Exercise Counteract Cancer Cachexia? A Systematic Literature Review and Meta-Analysis
Timo NielsAnnika TomanekNils Freitag, and Moritz Schumann
Exercise and Cancer Treatment
Research Article
Exercise Adherence and Effect of Self-Regulatory Behavior Change Techniques in Patients Undergoing Curative Cancer Treatment: Secondary Analysis from the Phys-Can Randomized Controlled Trial
Anne-Sophie MazzoniHannah L BrookeSveinung BerntsenKarin Nordin, and Ingrid Demmelmaier
Research Article
Effects of Steady Low-Intensity Exercise on High-Fat Diet Stimulated Breast Cancer Progression Via the Alteration of Macrophage Polarization
Min Kyoon KimYesl KimSeungHwa ParkEunju KimYerin KimYuri Kim, and Jung-Hyun Kim
Effects of Resistance Exercise on Symptoms, Physical Function, and Quality of Life in Gastrointestinal Cancer Patients Undergoing Chemotherapy
Yijin HongChunmei Wu, and Biyu Wu
Review Article
A Systematic Review of CheeZheng Pain Relieving Plaster for Musculoskeletal Pain: Implications for Oncology Research and Practice
Connie ChenSusan Q. LiTing BaoLily ZhangChristina Seluzicki, and Jun J. Mao
Effects of Nonpharmacological Interventions in Chemotherapy-Induced Peripheral Neuropathy: An Overview of Systematic Reviews and Meta-Analyses
Jie HaoXiaoshu Zhu, and Alan Bensoussan
A Review of Therapeutic Effects and the Pharmacological Molecular Mechanisms of Chinese Medicine Weifuchun in Treating Precancerous Gastric Conditions
Zhijian GuJianghong LingJun Cong, and Dan Li
20 Years of Integrative Cancer Therapies
Research Article
Overall Survival of Nonmetastasized NSCLC Patients Treated With Add-On Viscum album L: A Multicenter Real-World Study
Anja ThronickeBurkhard MatthesPhilipp von TrottFriedemann Schad, and Christian Grah
Research Article
Innovative Approach for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Pilot Study With the Hilotherm Device, the Poliambulanza Hospital Experience
Ester OnedaFausto MeriggiLaura ZanottiElisabetta ZainaSara BighèFederica AndreisSabogal Rueda, and Alberto Zaniboni
Exercise and Cancer Treatment
Research Article
A 12-Week Multi-Modal Exercise Program: Feasibility of Combined Exercise and Simplified 8-Style Tai Chi Following Lung Cancer Surgery
Ting LuLinda DenehyYuejiao CaoQirui CongEn WuCatherine L. GrangerJun Ni, and Lara Edbrooke
Research Article
Preliminary Efficacy and Safety of Reishi & Privet Formula on Quality of Life Among Non–Small Cell Lung Cancer Patients Undergoing Chemotherapy: A Randomized Placebo-Controlled Trial
Jie LiuJun J. MaoSusan Qing Li, and Hongsheng Lin
Eupatorin Suppressed Tumor Progression and Enhanced Immunity in a 4T1 Murine Breast Cancer Model
Nursyamirah Abd RazakSwee Keong YeapNoorjahan Banu AlitheenWan Yong HoChean Yeah YongSheau Wei TanWen Siang Tan, and Kamariah Long
The Influence of Spirituality and Religiosity on US Oncologists' Personal Use of and Clinical Practices Regarding Complementary and Alternative Medicine
Catherine Powers-JamesAdriana AlvarezKathrin MilburyAndrea BarboKatherine DaunovGabriel LopezLorenzo CohenMarvin O. Delgado-GuayOlufunmilayo I. Olopade, and Richard T. Lee
Review Article
A Systematic Literature Review of Animal-Assisted Interventions in Oncology (Part I): Methods and Results
Timothy R. N. HolderMargaret E. GruenDavid L. RobertsTamara Somers, and Alper Bozkurt
Research Article
Efficacy and Safety of Banxia XieXin Decoction, a Blended Traditional Chinese Medicine, as Monotherapy for Patients With Advanced Hepatocellular Carcinoma
Lijuan WangJianlong KeCui WangYaling LiGuoyu WuQian DingQiuyue LuoRui CaiPanpan LvTingting Song, and Shaoquan Xiong
Chinese Herbal Medicine Is Helpful for Survival Improvement in Patients With Multiple Myeloma in Taiwan: A Nationwide Retrospective Matched-Cohort Study
Chia-Yu HuangMei-Yao WuYu-Hung KuoSio-Ian Tou, and Hung-Rong Yen
Mind-Body and Psychosocial Interventions May Similarly Affect Heart Rate Variability Patterns in Cancer Recovery: Implications for a Mechanism of Symptom Improvement
Linda LarkeyWonsun KimDara JamesMoé KishidaMaricarmen VizcainoJennifer Huberty, and Narayanan Krishnamurthi
Study of the Radiosensitizing and Radioprotective Efficacy of Bromelain (a Pineapple Extract): In Vitro and In Vivo
Mai H. MekkawyHanan A. FahmyAhmed S. Nada, and Ola S. Ali
Exercise and Cancer Treatment
Research Article
Influence of a Structured Exercise Training on Patients Reported Quality of Life in Colorectal Cancer Patients After Adjuvant Chemotherapy: A Pilot Study
Gudrun PiringerBernhard HolznerBeate MayrbaeurlSonja HeiblMonika SztankaySophie FrantalMichael Gnant, and Josef Thaler
Emerging Integrative Therapies
Research Article
Role of Bee Venom and Melittin on Restraining Angiogenesis and Metastasis in γ-Irradiated Solid Ehrlich Carcinoma-Bearing Mice
Nermeen M. El BakaryAsmaa Z. AlsharkawyZeinab A. Shouaib, and Emad M. S. Barakat
Research Article
Lentinan Inhibits Tumor Progression by Immunomodulation in a Mouse Model of Bladder Cancer
Ming SunRenge BuBin ZhangYaming CaoChengyang Liu, and Wenyan Zhao
Platycodon grandiflorum Protects Against Anthracycline-Induced Cardiotoxicity in Early Breast Cancer Patients
Wei HaoYouyang ShiYuenong QinChenping SunLiying ChenChunyu WuYijia Bao, and Sheng Liu
Acupuncture for Hormone Therapy–Related Side Effects in Breast Cancer Patients: A GRADE-Assessed Systematic Review and Updated Meta-Analysis
Pan YuanqingTang YongLiang HaiqianChen GenXiping ShenJin DongCui Qi, and Qi Miaomiao
Review Article
A Systematic Literature Review of Animal-Assisted Interventions in Oncology (Part II): Theoretical Mechanisms and Frameworks
Timothy R. N. HolderMargaret E. GruenDavid L. RobertsTamara Somers, and Alper Bozkurt
Research Articles
Complementary Medicine Use and Uptake of Cancer Screening Among US Adults: A Nationally Representative Cross-Sectional Survey
Petra VoißMelanie Désirée HöxtermannGustav Dobos, and Holger Cramer
Research Article
Effects of Center-Based Delivery of Tai Chi and Qi Gong Group Classes on Self-Reported Symptoms in Cancer Patients and Caregivers
Gabriel LopezSanthosshi NarayananAimee ChristieCatherine Powers-JamesWenli LiuM Kay GarciaTelma GomezJimin WuAditi ChunduruJanet L. WilliamsYisheng LiEduardo Bruera, and Lorenzo Cohen
Managing Cancer and Living Meaningfully (CALM) Intervention on Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors
Ke DingXiuqing ZhangJingjing ZhaoHe ZuoZiran Bi, and Huaidong Cheng
Evaluation of an Integrative Care Program in Pediatric Oncology
Wiebke StritterBritta RutertAngelika EggertAlfred LänglerChristine Holmberg, and Georg Seifert
Development of Evidence-Based Chinese Medicine Clinical Service Recommendations for Cancer Palliative Care Using Delphi Approach Based on the Evidence to Decision Framework
Charlene H. L. WongIrene X. Y. WuJon AdamsAmie SteelJon WardleJustin C. Y. WuTing Hung Leung, and Vincent C. H. Chung
Emerging Integrative Therapies
Research Article
Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot Trial
Sun-Young MoonUi Min JerngO-Jin KwonSo-Young JungJee Young LeeSeong Woo YoonWon-Chul ShinJung-Ick Byun, and Jun-Hwan Lee
Research Article
The Leaf Extracts of Toona sinensis and Fermented Culture Broths of Antrodia camphorata Synergistically Cause Apoptotic Cell Death in Promyelocytic Leukemia Cells
Hsin-Ling YangYa-Ting KuoYugandhar Vudhya GowrisankarKai-Yuan LinLi-Sung HsuPei-Jane HuangHui-Chang Lin, and You-Cheng Hseu
Fatigue, Treatment Side Effects and Rehabilitation
Research Article
Impact of a Multimodal and Combination Therapy on Self-Regulation and Internal Coherence in German Breast Cancer Survivors With Chronic Cancer-Related Fatigue: A Mixed-Method Comprehensive Cohort Design Study
Annette MehlMarcus ReifRoland ZermDanilo PrangaDorothea FriemelBettina BergerBenno BrinkhausChristoph GutenbrunnerArndt Büssing, and Matthias Kröz
Impact of a Music Intervention on Quality of Life in Breast Cancer Patients Undergoing Chemotherapy: A Randomized Clinical Trial
Talita Uchoa LimaEd Carlos Rey MouraCaio Márcio Barros de OliveiraRachel Jorge Dino Cossetti LealJoão Nogueira NetoEmanuel Cabral PereiraRaniere Victor Braga NascimentoEduardo José Silva Gomes de Oliveira, and Plínio da Cunha Leal
Research Article
Effect of Chinese Herbal Compound LC09 on Patients With Capecitabine-Associated Hand-Foot Syndrome: A Randomized, Double-Blind, and Parallel-Controlled Trial
Ran YuXuefeng WuLiqun Jia, and Yanni Lou
Evaluation of the Efficacy and Safety of the Herbal Formula PM014 in a Cisplatin- and Paclitaxel-Treated Tumor-Bearing Mouse Model
Chanju LeeHyunju JeongKwang Hyung LeeSehyun ParkMi Jung GangSoo Kyung Bae, and Hyunsu Bae
A Polyphenol-Rich Extract From Muscadine Grapes Inhibits Triple-Negative Breast Tumor Growth
Marianne CollardPatricia E. Gallagher, and E. Ann Tallant
Efficacy of Ethyl Acetate Fraction of Cordyceps militaris for Cancer-Related Fatigue in Blood Biochemical and 1H-Nuclear Magnetic Resonance Metabolomic Analyses
Junsang OhEunhyun ChoiJayoung KimHeesu KimSangheun Lee, and Gi-Ho Sung
Application of Zizao Yangrong Granules for Treating Targeted Drugs–Related Skin Xerosis: A Randomized Double-Blinded Controlled Study
Yan Mei PengHua DuanJingyi ZhangChenyao SunXu ZhangWen ShenShuyue ZhengKexin TanXuejiao JiangJia Li, and Hui Juan Cui
Editorial
Integrative Cancer Therapies: Learning From COVID-19
Keith I. Block
Cancer and the Microbiome
Review Article
Microbiome as a Target for Cancer Therapy
Ratoe SurayaTatsuya NaganoKazuyuki Kobayashi, and Yoshihiro Nishimura
Research Article
Associations Between Global Mental Health and Response to an App-Based Meditation Intervention in Myeloproliferative Neoplasm Patients
Megan E. PuziaJennifer HubertyRyan EckertLinda Larkey, and Ruben Mesa
Effects and Relative Factors of Adjunctive Chinese Medicine Therapy on Survival of Hepatocellular Carcinoma Patients: A Retrospective Cohort Study in Taiwan
Yu-Pei LiaoPei-Tseng KungYueh-Hsin WangYeong-Ruey ChuShung-Te Kao, and Wen-Chen Tsai
Association Between Acupoint Selection, Target Symptoms, and Traditional Chinese Medicine Diagnosis in Real-Time Clinical Practice in a Comprehensive Cancer Center
Wenli LiuAiham QdaisatGabriel LopezSanthosshi NarayananSusan UnderwoodMichael SpanoAkhila ReddyYing GuoSai-Ching YeungEduardo Bruera, and Lorenzo Cohen
The Influence of Hypericin-Mediated Photodynamic Therapy on Interleukin-8 and -10 Secretion in Colon Cancer Cells
Marta Kaleta-RichterDavid AebisherDagmara JaworskaZenon CzubaGrzegorz Cieślar, and Aleksandra Kawczyk-Krupka
Factors Influencing Functional Exercise Capacity After Lung Resection for Non–Small Cell Lung Cancer
Masato OikawaMasatoshi HanadaHiroki NaguraTomoshi TsuchiyaKeitaro MatsumotoTakuro MiyazakiTerumitsu SawaiNaoya YamasakiTakeshi Nagayasu, and Ryo Kozu
Oncogenic and Circadian Effects of Small Molecules Directly and Indirectly Targeting the Core Circadian Clock
Hui-Hsien LinKelly L. RobertsonHeather A. Bisbee, and Michelle E. Farkas
A Randomized, Placebo-Controlled Trial Evaluating Changes in Peripheral Neuropathy and Quality of Life by Using Low-Frequency Electrostimulation on Breast Cancer Patients Treated With Chemotherapy
Si-Yeon SongJi-Hye ParkJin Sun LeeJe Ryong KimEun Hee SohnMi Sook Jung, and Hwa-Seung Yoo
Anticancer and Apoptogenic Effect of Graviola and Low-Dose Radiation in Tumor Xenograft in Mice
Ghada A. El TawiilEman Ali NoamanMostafa A. AskarNeama Mohamed El Fatih, and Hebatallah E. Mohamed
Acacetin and Pinostrobin Inhibit Malignant Breast Epithelial Cell Adhesion and Focal Adhesion Formation to Attenuate Cell Migration
Aaron A. Jones and Scott Gehler
Cancer and the Microbiome
Review Article
Diarrhea Induced by Small Molecule Tyrosine Kinase Inhibitors Compared With Chemotherapy: Potential Role of the Microbiome
Kate R. SecombeYsabella Z. A. Van SebilleBronwen J. MayoJanet K. CollerRachel J. Gibson, and Joanne M. Bowen
Case Study
Intravenous Honokiol in Drug-Resistant Cancer: Two Case Reports
Isaac Eliaz and Elaine Weil
Fatigue, Treatment Side Effects and Rehabilitation
Research Article
Impact of Oncological Therapy and Viscum album L Treatment on Cancer-Related Fatigue and Internal Coherence in Nonmetastasized Breast Cancer Patients
Shiao Li OeiAnja ThronickeMatthias KrözPhilipp von TrottFriedemann Schad, and Harald Matthes
Exercise and Cancer Treatment
Review Article
Effect of Exercise on Mortality and Recurrence in Patients With Cancer: A Systematic Review and Meta-Analysis
Shinichiro MorishitaYohei HamaueTakuya FukushimaTakashi TanakaJack B. Fu, and Jiro Nakano
Research Article
Feasibility and Effects of a Supervised Exercise Program Suitable for Independent Training at Home on Physical Function and Quality of Life in Head and Neck Cancer Patients: A Pilot Study
Sabine FelserMartin BehrensJan LieseDaniel Fabian StruederKirsten RhodeChristian Junghanss, and Christina Grosse-Thie
Gene Expression Profiling to Delineate the Anticancer Potential of a New Alkaloid Isopicrinine From Rhazya stricta
Nahid H. HajrahWaseem Mohammed AbdulZainab H. Abdul-HameedWalied M. AlarifNouf Saeed A. Al-AbbasSeif-Eldin N. AyyadAbdulkader M. Shaikh OmerMohammed Zainy MutawakilNeil HallAbdullah Y. ObaidRoop Singh BoraJamal S. M. Sabir, and Kulvinder Singh Saini
Influence of a Multidisciplinary Program of Diet, Exercise, and Mindfulness on the Quality of Life of Stage IIA-IIB Breast Cancer Survivors
Julia Ruiz-VozmedianoSarah LöhnchenLucas JuradoRosario RecioAndrea Rodríguez-CarrilloMiriam LópezVicente MustielesManuela ExpósitoManuel Arroyo-Morales, and Mariana F. Fernández
Greater Well-Being in More Physically Active Cancer Patients Who Are Enrolled in Supportive Care Services
Maíra Tristão ParraNaghmeh EsmeaeliJordan KohnBrook L. HenryStephen KlagholzShamini JainChristopher PruittDaniel VicarioWayne Jonas, and Paul J. Mills
Cordyceps militaris Exerts Anticancer Effect on Non–Small Cell Lung Cancer by Inhibiting Hedgehog Signaling via Suppression of TCTN3
Eunbi JoHyun-Jin JangLei ShenKyeong Eun YangMin Su JangYang Hoon HuhHwa-Seung YooJunsoo ParkIk Soon Jang, and Soo Jung Park
The Survival Benefit of Combination Therapy With Mild Temperature Hyperthermia and an Herbal Prescription of Gun-Chil-Jung in 54 Cancer Patients Treated With Chemotherapy or Radiation Therapy: A Retrospective Study
Hyeong Joon JunSo-Jung ParkHwi-Joong KangGa-Young LeeNamhun LeeJi Hye Park, and Hwa-Seung Yoo
Review Article
Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review
Mengyuan YangXian Zhong, and Ying Yuan
Research Article
Utilization of Complementary Alternative Medicine, Diet, and Exercise Among Women at High Risk for Developing Breast Cancer
Richard T. LeeAndrea AmicoDavid MalakaRachel LewinShelly A. CummingsMarion VerpLinda Patrick-MillerAngela R. Bradbury, and Olufunmilayo I. Olopade
Exercise and Cancer Treatment-Research Article
Attitudes and Perceptions to Prehabilitation in Lung Cancer
Anna ShuklaCatherine L. GrangerGavin M. WrightLara Edbrooke, and Linda Denehy
Research Article
Prophylaxis of Radiation-Induced Dermatitis in Patients With Breast Cancer Using Herbal Creams: A Prospective Randomized Controlled Trial
Saengrawee ThanthongRattanaporn NanthongSirikorn KongwattanakulKanyanee LaebuaPornwaree TrirussapanichSupaporn Pitiporn, and Danupon Nantajit
Gait Analysis of Patients After Allogeneic Hematopoietic Cell Transplantation Reveals Impairments of Functional Performance
Sarah KneisElisa StraubIsabelle Daniela WalzPhilipp von OlshausenAnja WehrleAlbert Gollhofer, and Hartmut Bertz
A Prospective Pilot Study on Use of Liquid Crystal Thermography to Detect Early Breast Cancer
Diana Hodorowicz-ZaniewskaStefano ZurridaAgnieszka KotlarzPiotr KasprzakJan SkupieńAnna ĆwierzTadeusz J. PopielaAdrian Maciejewski, and Paweł Basta
Outcomes of Therapeutic Artmaking in Patients Undergoing Radiation Oncology Treatment: A Mixed-Methods Pilot Study
Girija KaimalKatrina Carroll-HaskinsJanell L. MensingerRebekka Dieterich-HartwellJacelyn Biondo, and William P. Levin
Xiao-Ai-Ping Injection Enhances Effect of Paclitaxel to Suppress Breast Cancer Proliferation and Metastasis via Activating Transcription Factor 3
Junjun ChenXiangqi ZhangXiao XiaoYawei DingWei ZhangMeizhi ShiJiao YangYing Liu, and Yonglong Han
Combinatorial Effect of DCA and Let-7a on Triple-Negative MDA-MB-231 Cells: A Metabolic Approach of Treatment
Praveen Sharma and Sandeep Singh
Effects of Holothurian Glycosaminoglycan on the Sensitivity of Lung Cancer to Chemotherapy
Cunzhi LinXinhong ZhuQing JinAihua SuiJinfeng Li, and Liyan Shen
Exercise and Cancer Treatment
Research Article
Motivational Interviewing to Increase Physical Activity Behavior in Cancer Patients: A Pilot Randomized Controlled Trials
Alexis LionAnne BackesCaroline DuhemFernand RiesCharles DelagardelleAxel UrhausenClaus VögeleDaniel Theisen, and Laurent Malisoux
Research Article
A Phase I Study to Evaluate the Safety of the Herbal Medicine SH003 in Patients With Solid Cancer
Chunhoo Cheon and Seong-Gyu Ko
Mindfulness-Based Interventions in Recurrent Ovarian Cancer: A Mixed-Methods Feasibility Study
Emily Arden-CloseFelicity MitchellGail DaviesLauren BellCarole FoggRuth TarrantRoslyn Gibbs, and Chit Cheng Yeoh
Letter to the Editor
Challenges and Countermeasures of Integrative Cancer Therapy in the Epidemic of COVID-19
Geliang YangHuiqing Zhang, and Yufei Yang
Research Article
Randomized Feasibility Study of Meditative Practices in Hospitalized Cancer Patients
Santhosshi NarayananAkhila ReddyGabriel LopezWenli LiuJimin WuDiane LiuJoana ManzanoJanet L. WilliamsSmitha MallaiahMarina GeorgeJaya AmaramBalachandar SubramaniamLorenzo Cohen, and Eduardo Bruera
WITHDRAWAL – Administrative Duplicate Publication: Exploring the Use of Complementary and Alternative Medicine in Cancer Patients
Research Article
Nitidine Chloride Is a Potential Alternative Therapy for Glioma Through Inducing Endoplasmic Reticulum Stress and Alleviating Epithelial-Mesenchymal Transition
Zihang ChenJinsen ZhangHao XueMingyu QianXing GuoXiao GaoJianye XuYanhua QiXiaopeng Sun, and Gang Li
Interrater Reliability of Dynamic Muscle Testing After Breast Cancer Surgery in Women at High Risk of Lymphedema: To Improve Quality in Clinical Practice
Tina Korsholm-RosfortSimone LarsenThomas AagaardGunn Ammitzbøll, and Susanne O. Dalton
Attitudes Underlying Reliance on Complementary and Alternative Medicine
Szilvia ZörgőGjalt-Jorn Ygram Peters, and Samvel Mkhitaryan
The Efficacy and Safety of Acupuncture for Preventing Radiation Pneumonitis in Patients With Lung Cancer: A Prospective, Single-Blinded, Randomized Pilot Proof-of-Principle Study
Moonkyoo KongSeung Hyeun LeeJaehyo KimBeom-Joon Lee, and Kwan-Il Kim
Case Study
Prolonged Progression-Free Survival in a Patient With Malignant Pleural Mesothelioma Following Korean Herbal Medicine Treatment Alone: A Case Report
Sung Soo YoonEun Hye KimJee Young Lee, and Seong Woo Yoon
Exercise and Cancer Treatment
Research Article
Long-Term Favorable Effects of Physical Exercise on Burdensome Symptoms in the OptiTrain Breast Cancer Randomized Controlled Trial
Fleur WiggenraadKate A. BolamSara MijwelElsken van der WallYvonne Wengström, and Renske Altena
Research Article
A Retrospective Study of Gemcitabine and Carboplatin With or Without Intravenous Vitamin C on Patients With Advanced Triple-Negative Breast Cancer
Junwen OuXinyu ZhuHongyu ZhangYanping DuPengfei ChenJunhua WangXiufan PengShuang BaoXinting ZhangTao Zhang, and Clifford L. K. Pang
Commentary
A Proposed Revision of the International Classification of Diseases, 11th Revision, Chapter 26
Seung-hoon Choi
Research Article
Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone
Ali H. El-FarNoureldien H. E. Darwish, and Shaker A. Mousa
Jianpi-Huayu Formula Inhibits Development of Hepatocellular Carcinoma by Regulating Expression of miR-602, Which Targets the RASSF1A Gene
Yajing HuangCheng ZhouHuihong WenYongxu ChenYingjie XieXiaohe LanJuze LinXuhui HuangYousheng MoCong YangQi Wang, and Changjun Wang
Qigong Mind-Body Exercise as a Biopsychosocial Therapy for Persistent Post-Surgical Pain in Breast Cancer: A Pilot Study
Kamila OsypiukJennifer LigibelAnita Giobbie-HurderGloria Vergara-DiazPaolo BonatoRoxanne QuinnWinnie Ng, and Peter M. Wayne
Case Studies
Paratesticular Mesenchymal Malignancies: A Single-Center Case Series, Clinical Management, and Review of Literature
Lidia GattoMassimo Del GaudioMatteo RavaioliMatteo CesconValeria ToniniMaurizio CervelleraAlessandro FranceschelliMaria Giulia PiriniValerio Di ScioscioFrancesco BuiaFabio NiroElisa CapizziMichelangelo FiorentinoAnnalisa AstolfiValentina IndioMargherita NanniniMaria Abbondanza Pantaleo, and Maristella Saponara
Research Article
Cell Wall Membrane Fraction of Chlorella sorokiniana Enhances Host Antitumor Immunity and Inhibits Colon Carcinoma Growth in Mice
Susumu IshiguroNicole RobbenRiley BurghartPaige CoteSarah GreenwayRavindra ThakkarDeepa UpretiAyaka NakashimaKengo SuzukiJeffrey Comer, and Masaaki Tamura
Japanese Kampo Medicine Juzentaihoto Enhances Antitumor Immunity in CD1d−/− Mice Lacking NKT Cells
Shun TakakuMasumi Shimizu, and Hidemi Takahashi
Emerging Integrative Therapies
Research Articles
Long-Term Effect of a Nonrandomized Psychosocial Mindfulness-Based Intervention in Hispanic/Latina Breast Cancer Survivors
Elizabeth ElimimianLeah ElsonNadeem BilaniSafa E. FarragAlok Kumar DwivediRebecca Pasillas, and Zeina A. Nahleh
Patient Perspectives Article
Breast Cancer With Brain Metastases: Perspective From a Long-Term Survivor
Christopher P. Kofron and Angela Chapman

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