Κυριακή 28 Ιουλίου 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


MDPI
Vaccines, Vol. 7, Pages 75: Why New Vaccines for the Control of Ectoparasite Vectors Have Not Been Registered and Commercialized?Vaccines, Vol. 7, Pages 75: Why New Vaccines for the Control of Ectoparasite Vectors Have Not Been Registered and Commercialized? Vaccines doi: 10.3390/vaccines7030075 Authors: José de la Fuente Agustín Estrada-Peña The prevention and control of vector-borne diseases is a priority for improving global health. Despite recent advances in the characterization of ectoparasite-host-pathogen...
Medicine by Alexandros G. Sfakianakis
08:35
Water, Vol. 11, Pages 1560: Multiple Effects of Intense Meteorological Events in the Benevento...
Water, Vol. 11, Pages 1560: Multiple Effects of Intense Meteorological Events in the Benevento Province, Southern ItalyWater, Vol. 11, Pages 1560: Multiple Effects of Intense Meteorological Events in the Benevento Province, Southern Italy Water doi: 10.3390/w11081560 Authors: Paola Revellino Luigi Guerriero Neri Mascellaro Francesco Fiorillo Gerardo Grelle Giuseppe Ruzza Francesco M. Guadagno In October 2015, two intense rainfall events hit the central and southern regions of Italy and triggered...
Medicine by Alexandros G. Sfakianakis
08:35
Viruses, Vol. 11, Pages 689: Purification and Functional Characterization of a Biologically Active...
Viruses, Vol. 11, Pages 689: Purification and Functional Characterization of a Biologically Active Full-Length Feline Immunodeficiency Virus (FIV) Pr50GagViruses, Vol. 11, Pages 689: Purification and Functional Characterization of a Biologically Active Full-Length Feline Immunodeficiency Virus (FIV) Pr50Gag Viruses doi: 10.3390/v11080689 Authors: Anjana Krishnan Vineeta N. Pillai Akhil Chameettachal Lizna Mohamed Ali Fathima Nuzra Nagoor Pitchai Saeed Tariq Farah Mustafa Roland Marquet Tahir A. Rizvi...
Medicine by Alexandros G. Sfakianakis
08:34
Urban Science, Vol. 3, Pages 81: Landscape as Connecting Link of Nature and Culture: Spatial Planning...
Urban Science, Vol. 3, Pages 81: Landscape as Connecting Link of Nature and Culture: Spatial Planning Policy Implications in GreeceUrban Science, Vol. 3, Pages 81: Landscape as Connecting Link of Nature and Culture: Spatial Planning Policy Implications in Greece Urban Science doi: 10.3390/urbansci3030081 Authors: Stella Sofia Kyvelou Anestis Gourgiotis The research paper investigates the diverse understandings of "landscape", along with demonstrating the modes of contribution of the European Landscape...
Medicine by Alexandros G. Sfakianakis
08:34
Toxins, Vol. 11, Pages 447: Label-Free Fluorescent Aptasensor for Ochratoxin—A Detection Based...
Toxins, Vol. 11, Pages 447: Label-Free Fluorescent Aptasensor for Ochratoxin—A Detection Based on CdTe Quantum Dots and (N-Methyl-4-pyridyl) PorphyrinToxins, Vol. 11, Pages 447: Label-Free Fluorescent Aptasensor for Ochratoxin—A Detection Based on CdTe Quantum Dots and (N-Methyl-4-pyridyl) Porphyrin Toxins doi: 10.3390/toxins11080447 Authors: Li Liu Zafar Iqbal Tanveer Keqiu Jiang Qingwen Huang Jinghui Zhang Yongjiang Wu Zheng Han With the widespread contamination of ochratoxin A (OTA), it is of...
Medicine by Alexandros G. Sfakianakis
08:33
Resources, Vol. 8, Pages 133: Effect of Recycled Plastic Granules as a Partial Substitute for...
Resources, Vol. 8, Pages 133: Effect of Recycled Plastic Granules as a Partial Substitute for Natural Resource Sand on the Durability of SCCResources, Vol. 8, Pages 133: Effect of Recycled Plastic Granules as a Partial Substitute for Natural Resource Sand on the Durability of SCC Resources doi: 10.3390/resources8030133 Authors: Bala Rama Krishna Chunchu Jagadeesh Putta This investigation is focused on durability studies of binary blended self-compacting concrete (SCC) with the replacement effect...
Medicine by Alexandros G. Sfakianakis
08:32
Religions, Vol. 10, Pages 455: Using Verbal Art to Deal with Conflicts: Women's Voices on Family...
Religions, Vol. 10, Pages 455: Using Verbal Art to Deal with Conflicts: Women's Voices on Family and Kinship in Kāmākhyā (Assam)Religions, Vol. 10, Pages 455: Using Verbal Art to Deal with Conflicts: Women's Voices on Family and Kinship in Kāmākhyā (Assam) Religions doi: 10.3390/rel10080455 Authors: Arrago-Boruah Analyzing two women's rituals in which verbal art on family and kinship is prominent, this article explores situations in which tales and songs in Assamese are staged by newly married and...
Medicine by Alexandros G. Sfakianakis
08:32
Sex Robots. A Feminist Dystopia/Utopia
Social Sciences, Vol. 8, Pages 225: Measuring Peripherality as a Proxy for Autonomous Community Coping Capacity: A Case Study from Bua Province, Fiji Islands, for Improving Climate Change AdaptationSocial Sciences, Vol. 8, Pages 225: Measuring Peripherality as a Proxy for Autonomous Community Coping Capacity: A Case Study from Bua Province, Fiji Islands, for Improving Climate Change Adaptation Social Sciences doi: 10.3390/socsci8080225 Authors: Nunn Kumar Over the past thirty years, externally-driven...
Medicine by Alexandros G. Sfakianakis
08:32
Plants, Vol. 8, Pages 253: The Dynamic Genetic-Hormonal Regulatory Network Controlling the Trichome...
Plants, Vol. 8, Pages 253: The Dynamic Genetic-Hormonal Regulatory Network Controlling the Trichome Development in LeavesPlants, Vol. 8, Pages 253: The Dynamic Genetic-Hormonal Regulatory Network Controlling the Trichome Development in Leaves Plants doi: 10.3390/plants8080253 Authors: Marco Fambrini Claudio Pugliesi Plant trichomes are outgrowths developed from an epidermal pavement cells of leaves and other organs. Trichomes (also called 'hairs') play well-recognized roles in defense against insect...
Medicine by Alexandros G. Sfakianakis
08:31
Nutrients, Vol. 11, Pages 1742: A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie...
Nutrients, Vol. 11, Pages 1742: A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones?Nutrients, Vol. 11, Pages 1742: A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones? Nutrients doi: 10.3390/nu11081742 Authors: Cherubino Di Lorenzo Alessandro Pinto Roberta Ienca Gianluca Coppola Giulio Sirianni Giorgio Di Lorenzo Vincenzo Parisi Mariano Serrao...
Medicine by Alexandros G. Sfakianakis
08:31
Molecules, Vol. 24, Pages 2742: Aquaphotomics—From Innovative Knowledge to Integrative Platform...
Molecules, Vol. 24, Pages 2742: Aquaphotomics—From Innovative Knowledge to Integrative Platform in Science and TechnologyMolecules, Vol. 24, Pages 2742: Aquaphotomics—From Innovative Knowledge to Integrative Platform in Science and Technology Molecules doi: 10.3390/molecules24152742 Authors: Jelena Muncan Roumiana Tsenkova Aquaphotomics is a young scientific discipline based on innovative knowledge of water molecular network, which as an intrinsic part of every aqueous system is being shaped by all...
Medicine by Alexandros G. Sfakianakis
08:30
Nanomaterials, Vol. 9, Pages 1083: Enhancement in Photoelectrochemical Performance of Optimized...
Nanomaterials, Vol. 9, Pages 1083: Enhancement in Photoelectrochemical Performance of Optimized Amorphous SnS2 Thin Film Fabricated through Atomic Layer DepositionNanomaterials, Vol. 9, Pages 1083: Enhancement in Photoelectrochemical Performance of Optimized Amorphous SnS2 Thin Film Fabricated through Atomic Layer Deposition Nanomaterials doi: 10.3390/nano9081083 Authors: Weiguang Hu Truong Thi Hien Dojin Kim Hyo Sik Chang Two-dimensional (2D) nanomaterials have distinct optical and electrical properties...
Medicine by Alexandros G. Sfakianakis
08:30
Microorganisms, Vol. 7, Pages 220: Gaseous Ozonation to Reduce Aflatoxins Levels and Microbial...
Microorganisms, Vol. 7, Pages 220: Gaseous Ozonation to Reduce Aflatoxins Levels and Microbial Contamination in Corn GritsMicroorganisms, Vol. 7, Pages 220: Gaseous Ozonation to Reduce Aflatoxins Levels and Microbial Contamination in Corn Grits Microorganisms doi: 10.3390/microorganisms7080220 Authors: Yuri Duarte Porto Felipe Machado Trombete Otniel Freitas-Silva Izabela Miranda de Castro Gloria Maria Direito José Luis Ramirez Ascheri Corn is one of the most cultivated cereals in Brazil. However,...
Medicine by Alexandros G. Sfakianakis
08:29
Medicina, Vol. 55, Pages 415: Risk-Reducing Bilateral Salpingo-Oophorectomy for BRCA Mutation...
Medicina, Vol. 55, Pages 415: Risk-Reducing Bilateral Salpingo-Oophorectomy for BRCA Mutation Carriers and Hormonal Replacement Therapy: If It Should Rain, Better a Drizzle than a StormMedicina, Vol. 55, Pages 415: Risk-Reducing Bilateral Salpingo-Oophorectomy for BRCA Mutation Carriers and Hormonal Replacement Therapy: If It Should Rain, Better a Drizzle than a Storm Medicina doi: 10.3390/medicina55080415 Authors: Maria Luisa Gasparri Katayoun Taghavi Enrico Fiacco Veronica Zuber Rosa Di Micco Guglielmo...
Medicine by Alexandros G. Sfakianakis
08:28
JCM, Vol. 8, Pages 1121: Negative Self-Perception and Self-Attitude of Sexuality Is a Risk Factor...
JCM, Vol. 8, Pages 1121: Negative Self-Perception and Self-Attitude of Sexuality Is a Risk Factor for Patient Dissatisfaction Following Penile Surgery with Small Intestinal Submucosa Grafting for the Treatment of Severe Peyronie's DiseaseJCM, Vol. 8, Pages 1121: Negative Self-Perception and Self-Attitude of Sexuality Is a Risk Factor for Patient Dissatisfaction Following Penile Surgery with Small Intestinal Submucosa Grafting for the Treatment of Severe Peyronie's Disease Journal of Clinical Medicine...
Medicine by Alexandros G. Sfakianakis
08:27
Holographic Three-Dimensional Imaging of Terra-Cotta Warrior Model Using Fractional Fourier Transform...
Holographic Three-Dimensional Imaging of Terra-Cotta Warrior Model Using Fractional Fourier TransformJ. Imaging, Vol. 5, Pages 67: Holographic Three-Dimensional Imaging of Terra-Cotta Warrior Model Using Fractional Fourier Transform Journal of Imaging doi: 10.3390/jimaging5080067 Authors: Zhi-Fang Gao Hua-Dong Zheng Ying-Jie Yu Holographic three-dimensional (3D) imaging of Terra-Cotta Warrior model using Fractional Fourier Transform is introduced in this paper. Phase holograms of Terra-Cotta Warrior...
Medicine by Alexandros G. Sfakianakis
08:27
IJMS, Vol. 20, Pages 3660: Production of Hexaric Acids from Biomass IJMS, Vol. 20, Pages 3660:...
IJMS, Vol. 20, Pages 3660: Production of Hexaric Acids from BiomassIJMS, Vol. 20, Pages 3660: Production of Hexaric Acids from Biomass International Journal of Molecular Sciences doi: 10.3390/ijms20153660 Authors: Riku Sakuta Nobuhumi Nakamura Sugar acids obtained by aldohexose oxidation of both the terminal aldehyde group and the hydroxy group at the other end to carboxyl groups are called hexaric acids (i.e., six-carbon aldaric acids). Because hexaric acids have four secondary hydroxy groups that...
Medicine by Alexandros G. Sfakianakis
08:26
IJMS, Vol. 20, Pages 3700: Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis...
IJMS, Vol. 20, Pages 3700: Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma CellsIJMS, Vol. 20, Pages 3700: Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20153700 Authors: Kiyohiro Ando Yohko Nakamura Hiroki Nagase Akira Nakagawara Tsugumichi Koshinaga Satoshi Wada Makoto Makishima Checkpoint kinase 1 (CHK1) is a central mediator of the DNA damage response...
Medicine by Alexandros G. Sfakianakis
08:26
IJERPH, Vol. 16, Pages 2698: Cognitive Impairment Is Independently Associated with Non-Adherence...
IJERPH, Vol. 16, Pages 2698: Cognitive Impairment Is Independently Associated with Non-Adherence to Antithrombotic Therapy in Older Patients with Atrial FibrillationIJERPH, Vol. 16, Pages 2698: Cognitive Impairment Is Independently Associated with Non-Adherence to Antithrombotic Therapy in Older Patients with Atrial Fibrillation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16152698 Authors: Hyun-Joo Seong Kyounghoon Lee Bo-Hwan Kim Youn-Jung Son Atrial Fibrillation...
Medicine by Alexandros G. Sfakianakis
08:25
Heritage, Vol. 2, Pages 2228-2242: Conservation of Cultural Heritage: Issues along the Thapathali-Teku...
Heritage, Vol. 2, Pages 2228-2242: Conservation of Cultural Heritage: Issues along the Thapathali-Teku stretch of the Bagmati River in Kathmandu, NepalHeritage, Vol. 2, Pages 2228-2242: Conservation of Cultural Heritage: Issues along the Thapathali-Teku stretch of the Bagmati River in Kathmandu, Nepal Heritage doi: 10.3390/heritage2030135 Authors: Anita Tamrakar Rishi Ram Parajuli The Bagmati, an auspicious and sacred river, is adorned with Ghat, Dharmashalas, Pati, Sattals, Temples, Brahmanaal etc....
Medicine by Alexandros G. Sfakianakis
08:24
Foods, Vol. 8, Pages 296: Characterization of Soaking Process' Impact in Common Beans Phenolic...
Foods, Vol. 8, Pages 296: Characterization of Soaking Process' Impact in Common Beans Phenolic Composition: Contribute from the Unexplored Portuguese GermplasmFoods, Vol. 8, Pages 296: Characterization of Soaking Process' Impact in Common Beans Phenolic Composition: Contribute from the Unexplored Portuguese Germplasm Foods doi: 10.3390/foods8080296 Authors: Elsa Mecha Susana T. Leitão Bruna Carbas Ana T. Serra Pedro M. Moreira Maria Manuela Veloso Ricardo Gomes Maria E. Figueira Carla Brites Maria...
Medicine by Alexandros G. Sfakianakis
08:24
Environments, Vol. 6, Pages 89: Odours in Sewerage—A Description of Emissions and of Technical...
Environments, Vol. 6, Pages 89: Odours in Sewerage—A Description of Emissions and of Technical Abatement MeasuresEnvironments, Vol. 6, Pages 89: Odours in Sewerage—A Description of Emissions and of Technical Abatement Measures Environments doi: 10.3390/environments6080089 Authors: Pochwat Kida Ziembowicz Koszelnik Malodorous compounds arise at practically every stage of wastewater management, starting from the sewer network, via the technological sewage-treatment system, through to the sludge-management...
Medicine by Alexandros G. Sfakianakis
08:23
Diversity, Vol. 11, Pages 124: Movement and Home Range of the Smooth Softshell Turtle (Apalone...
Diversity, Vol. 11, Pages 124: Movement and Home Range of the Smooth Softshell Turtle (Apalone mutica): Spatial Ecology of a River SpecialistDiversity, Vol. 11, Pages 124: Movement and Home Range of the Smooth Softshell Turtle (Apalone mutica): Spatial Ecology of a River Specialist Diversity doi: 10.3390/d11080124 Authors: Jason P. Ross Robert D. Bluett Michael J. Dreslik Spatial ecological information is necessary to guide the conservation efforts of river turtles, but it is lacking for many species...
Medicine by Alexandros G. Sfakianakis
08:23
Cells, Vol. 8, Pages 785: Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis...
Cells, Vol. 8, Pages 785: Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin InflammationCells, Vol. 8, Pages 785: Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation Cells doi: 10.3390/cells8080785 Authors: Shahzad Nawaz Syed Rebecca Raue Andreas Weigert Andreas von Knethen Bernhard Brüne The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate...
Medicine by Alexandros G. Sfakianakis
08:22
Diagnostics, Vol. 9, Pages 85: Left Ventricular Dysfunction and Plasmatic NT-proBNP Are Associated...
Diagnostics, Vol. 9, Pages 85: Left Ventricular Dysfunction and Plasmatic NT-proBNP Are Associated with Adverse Evolution in Respiratory Syncytial Virus BronchiolitisDiagnostics, Vol. 9, Pages 85: Left Ventricular Dysfunction and Plasmatic NT-proBNP Are Associated with Adverse Evolution in Respiratory Syncytial Virus Bronchiolitis Diagnostics doi: 10.3390/diagnostics9030085 Authors: Rodriguez-Gonzalez Perez-Reviriego Castellano-Martinez Lubian-Lopez Benavente-Fernandez Aim: To investigate whether...
Medicine by Alexandros G. Sfakianakis
08:22
Cancers, Vol. 11, Pages 1068: Nomogram for Predicting Survival in Patients Treated with Liposomal...
Cancers, Vol. 11, Pages 1068: Nomogram for Predicting Survival in Patients Treated with Liposomal Irinotecan Plus Fluorouracil and Leucovorin in Metastatic Pancreatic CancerCancers, Vol. 11, Pages 1068: Nomogram for Predicting Survival in Patients Treated with Liposomal Irinotecan Plus Fluorouracil and Leucovorin in Metastatic Pancreatic Cancer Cancers doi: 10.3390/cancers11081068 Authors: Chen Macarulla Blanc Mirakhur Jong Belanger Bekaii-Saab Siveke NAPOLI-1 (NCT01494506) was a phase III study...
Medicine by Alexandros G. Sfakianakis
08:21
Brain Sciences, Vol. 9, Pages 181: Magnetic Source Imaging and Infant MEG: Current Trends and...
Brain Sciences, Vol. 9, Pages 181: Magnetic Source Imaging and Infant MEG: Current Trends and Technical AdvancesBrain Sciences, Vol. 9, Pages 181: Magnetic Source Imaging and Infant MEG: Current Trends and Technical Advances Brain Sciences doi: 10.3390/brainsci9080181 Authors: Chieh Kao Yang Zhang Magnetoencephalography (MEG) is known for its temporal precision and good spatial resolution in cognitive brain research. Nonetheless, it is still rarely used in developmental research, and its role in...
Medicine by Alexandros G. Sfakianakis
08:21
Biomolecules, Vol. 9, Pages 313: Limited Antioxidant Effect of Rosemary in Lipid Oxidation of...
Biomolecules, Vol. 9, Pages 313: Limited Antioxidant Effect of Rosemary in Lipid Oxidation of Pan-Fried SalmonBiomolecules, Vol. 9, Pages 313: Limited Antioxidant Effect of Rosemary in Lipid Oxidation of Pan-Fried Salmon Biomolecules doi: 10.3390/biom9080313 Authors: Kin Sum Leung Ho Hang Leung Ching Yu Wu Jean-Marie Galano Thierry Durand Jetty Chung-Yung Lee Consumption of omega-3 polyunsaturated fatty acids (n-3 PUFAs) rich fatty fish is known to provide an array of health benefits. However, high...
Medicine by Alexandros G. Sfakianakis
08:20
Biology, Vol. 8, Pages 56: Combined Effects of Acute Temperature Change and Elevated pCO2 on the...
Biology, Vol. 8, Pages 56: Combined Effects of Acute Temperature Change and Elevated pCO2 on the Metabolic Rates and Hypoxia Tolerances of Clearnose Skate (Rostaraja eglanteria), Summer Flounder (Paralichthys dentatus), and Thorny Skate (Amblyraja radiata)Biology, Vol. 8, Pages 56: Combined Effects of Acute Temperature Change and Elevated pCO2 on the Metabolic Rates and Hypoxia Tolerances of Clearnose Skate (Rostaraja eglanteria), Summer Flounder (Paralichthys dentatus), and Thorny Skate (Amblyraja...
Medicine by Alexandros G. Sfakianakis
08:18
Atmosphere, Vol. 10, Pages 437: Multi-Channel Regression Inversion Method for Passive Remote Sensing...
Atmosphere, Vol. 10, Pages 437: Multi-Channel Regression Inversion Method for Passive Remote Sensing of Ice Water Path in the Terahertz BandAtmosphere, Vol. 10, Pages 437: Multi-Channel Regression Inversion Method for Passive Remote Sensing of Ice Water Path in the Terahertz Band Atmosphere doi: 10.3390/atmos10080437 Authors: Chensi Weng Lei Liu Taichang Gao Shuai Hu Shulei Li Fangli Dou Jian Shang Retrieval of ice cloud properties using passive terahertz wave radiometer from space has gained increasing...
Medicine by Alexandros G. Sfakianakis
08:18
Workers and Nationalism: Czech and German Social Democracy in Habsburg Austria, 1890–1918  Ke-Chin Hsia  The...
Workers and Nationalism: Czech and German Social Democracy in Habsburg Austria, 1890–1918  Ke-Chin Hsia  The Habsburg Monarchy 1815–1918  Jakub Beneš  German Catholicism at War, 1939–1945  Beth A Griech-Polelle 
Medicine by Alexandros G. Sfakianakis
07:35
Antifungal Stewardship Programs and candidemia  Carlo Tascini; Giacomo Bertolino; Emanuela Sozio; Francesco...
Antifungal Stewardship Programs and candidemia  Carlo Tascini; Giacomo Bertolino; Emanuela Sozio; Francesco Sbrana ; Andrea Ripoli ...  Reply to Tascini, et al  Rachael A Lee, MD; Todd P McCarty, MD; Bernard C Camins, MD, MSc; J Martin Rodriguez, MD ; Peter G Pappas, MD  Bouillabaisse or Fish soup: The Limitations of Meta-Analysis confronted to the Inconsistency of Fecal Microbiota Transplantation Studies  Jean-Christophe Lagier; Matthieu Million; Didier Raoult  Reply to Lagier et al  Raseen Tariq,...
Medicine by Alexandros G. Sfakianakis
07:35
Extent of maxillary sinus surgery and its effect on instrument access, irrigation penetration, and...
Extent of maxillary sinus surgery and its effect on instrument access, irrigation penetration, and disease clearanceRevadi Govindaraju MD, MS  Lisa Cherian MS (ENT)  Luis Macias‐Valle MD, FARS  Jae Murphy MBBS, PhD Michael Gouzos MD  Sarah Vreugde MD PhD  Peter John Wormald FRCS, FRACS … See all authorsFirst published: 25 July 2019 https://doi.org/10.1002/alr.22397Conflicts of interest: A.J.P.: ENT Technologies, Aerin Medical Technologies, Lyra Therapeutics, and Medtronic, consultant. P.J.W.: Medtronic,...
Medicine by Alexandros G. Sfakianakis
07:34
The Principle of Subsidiarity for Sustainable Development in Church-State Relationship in Nigeria  Lawrence...
The Principle of Subsidiarity for Sustainable Development in Church-State Relationship in Nigeria  Lawrence Nwachukwu Okwuosa; Cosmos Ndulor; Nkechi Gloria Onah; Chinyere Theresa Nwaoga ; Favour Chukwuemeka Uroko
Medicine by Alexandros G. Sfakianakis
07:34
Sinus irrigation penetration after balloon sinuplasty vs functional endoscopic sinus surgery in a cadaveric...
Sinus irrigation penetration after balloon sinuplasty vs functional endoscopic sinus surgery in a cadaveric modelOliver Gantz MD  Arman Danielian BS  Alison Yu BA  Elisabeth H. Ference MD, MPH  Edward C. Kuan MD, MBA  Bozena Wrobel MDFirst published: 23 July 2019 https://doi.org/10.1002/alr.22386Potential conflict of interest: This work was not supported financially by any company or industry partner. The specimens, endoscopes, and imaging equipment were provided by Olympus America, Center Valley,...
Medicine by Alexandros G. Sfakianakis
07:34
International Forum of Allergy & Rhinology Early View Online Version of Record before inclusion...
International Forum of Allergy & RhinologyEarly ViewOnline Version of Record before inclusion in an issueOriginal ArticlesExtent of maxillary sinus surgery and its effect on instrument access, irrigation penetration, and disease clearanceRevadi Govindaraju MD, MS, Lisa Cherian MS (ENT), Luis Macias‐Valle MD, FARS, Jae Murphy MBBS, PhD, Michael Gouzos MD, Sarah Vreugde MD PhD, Peter John Wormald FRCS, FRACS, Ahmed Bassiouni MD, PhD, Alkis James Psaltis FRACS, PhDVersion of Record online: 25 July...
Medicine by Alexandros G. Sfakianakis
07:33
From Natural Character to Moral Virtue in Aristotle   Tom Angier That natural conditions—including,...
From Natural Character to Moral Virtue in Aristotle   Tom AngierThat natural conditions—including, paradigmatically, human biological functioning, but ranging also over extra-human conditions (such as the environment)—are deeply relevant to ethical norms probably strikes the average person as a truism. But since Hume and Kant, many if not most moral philosophers have sidelined such conditions and tried to ground ethical norms differently: typically, in contingent desire or formalistic conceptions...
Medicine by Alexandros G. Sfakianakis
07:32
PAPASH, PsAPASH and PASS autoinflammatory syndromes: phenotypic heterogeneity, common biological signature...
PAPASH, PsAPASH and PASS autoinflammatory syndromes: phenotypic heterogeneity, common biological signature and response to immunosuppressive regimensJ. Gottlieb  M. Madrange  C. Gardair  E. Sbidian  A. Frazier  P. Wolkenstein  G. Hickman  P. Schneider  C. Baudry  P. Claudepierre  P. Bertheau  P. Richette  A. Smahi  H. BachelezFirst published: 13 April 2019 https://doi.org/10.1111/bjd.18003
Medicine by Alexandros G. Sfakianakis
07:26
British Journal of Dermatology Early View Online Version of Record before inclusion in an issue ...
British Journal of DermatologyEarly ViewOnline Version of Record before inclusion in an issueResearch LettersPAPASH, PsAPASH and PASS autoinflammatory syndromes: phenotypic heterogeneity, common biological signature and response to immunosuppressive regimensJ. Gottlieb, M. Madrange, C. Gardair, E. Sbidian, A. Frazier, P. Wolkenstein, G. Hickman, P. Schneider, C. Baudry, P. Claudepierre, P. Bertheau, P. Richette, A. Smahi, H. BachelezVersion of Record online: 25 July 2019 Open AccessClinical TrialsSustained...
Medicine by Alexandros G. Sfakianakis
07:26

Angiogenesis
A new prognostic model for survival in second line for metastatic renal cell carcinoma: development and external validationAbstractBackgroundIn patients with metastatic renal cell carcinoma (mRCC), the oncologic benefit of second-line treatment for high volume tumors or presence of more than five risk factors remain to be defined. Our aim was to develop and externally validate a new model most likely to correctly predict overall survival (OS) categories in second line.MethodmRCC patients treated...
Medicine by Alexandros G. Sfakianakis
07:22
The role of poor oral health in surgical site infection following elective spinal surgery AbstractStudy...
The role of poor oral health in surgical site infection following elective spinal surgeryAbstractStudy designCross-sectional study.ObjectivesTo describe oral health and hygiene as a risk factor for surgical site infection (SSI).MethodsThis cross-sectional study was conducted on patients over 18 years of age who were candidates for elective spinal surgery. The exclusion criteria were immunodeficiency, history of cancer, history of previous infection at the surgical site, cutaneous diseases and long-term...
Medicine by Alexandros G. Sfakianakis
07:13
The role of poor oral health in surgical site infection following elective spinal surgery AbstractStudy...
The role of poor oral health in surgical site infection following elective spinal surgeryAbstractStudy designCross-sectional study.ObjectivesTo describe oral health and hygiene as a risk factor for surgical site infection (SSI).MethodsThis cross-sectional study was conducted on patients over 18 years of age who were candidates for elective spinal surgery. The exclusion criteria were immunodeficiency, history of cancer, history of previous infection at the surgical site, cutaneous diseases and long-term...
Medicine by Alexandros G. Sfakianakis
07:11
Surgical strategy in extensive proximal brachial plexus palsies AbstractPurpose To describe and assess...
Surgical strategy in extensive proximal brachial plexus palsiesAbstractPurposeTo describe and assess an overall surgical strategy addressing extensive proximal brachial plexus injuries (BPI).MethodsForty-five consecutive patients' charts with C5–C6–C7 and C5–C6–C7–C8 BPI were reviewed. Primary procedures were nerve transfers to restore elbow function and grafts to restore shoulder function when a cervical root was available; when nerve surgery was not possible or had failed, tendon transfers were...
Medicine by Alexandros G. Sfakianakis
07:11
Musculoskeletal Surgery
Minimally invasive plate osteosynthesis (MIPO) in AO/OTA type B displaced clavicle fracturesAbstractIntroductionOpen reduction and plate fixation is known to reduce chances of malunion and symptomatic nonunion in displaced middle-third clavicle fractures. However, this treatment modality is also associated with several complications, such as hardware irritation, numbness around the surgical scar, infection, nonunion and implant failure. The minimally invasive plate osteosynthesis (MIPO) technique...
Medicine by Alexandros G. Sfakianakis
07:10
Effects of testosterone on circadian rhythmicity in olds
 miceAbstractSerum testosterone concentration decreases with age in humans and rodents. Accordingly, old male mice show changes in locomotor activity rhythms: a lengthened free-running period and decreased activity levels among others. To investigate whether testosterone replacement improves the age-related decline in circadian rhythmicity, we examined the effects of testosterone on the circadian rhythms of wheel running activity in old male mice. Intact male C57BL/6J mice (18–22 months old) were...
Medicine by Alexandros G. Sfakianakis
07:07
Factors inhibiting intestinal calcium absorption: hormones and luminal factors that prevent excessive...
Factors inhibiting intestinal calcium absorption: hormones and luminal factors that prevent excessive calcium uptakeAbstractBesides the two canonical calciotropic hormones, namely parathyroid hormone and 1,25-dihydroxyvitamin D [1,25(OH)2D3], there are several other endocrine and paracrine factors, such as prolactin, estrogen, and insulin-like growth factor that have been known to directly stimulate intestinal calcium absorption. Generally, to maintain an optimal plasma calcium level, these positive...
Medicine by Alexandros G. Sfakianakis
07:07
Intermittent hyperbaric oxygen exposure mobilizing peroxiredoxin 6 to prevent oxygen toxicity Abstract...
Intermittent hyperbaric oxygen exposure mobilizing peroxiredoxin 6 to prevent oxygen toxicityAbstractIntermittent hyperbaric oxygen exposure (IE-HBO) can protect the body against oxygen toxicity, but the underlying mechanisms are not very clear. Peroxiredoxin 6 (Prdx6) is a special endogenous antioxidative protein. We explored if the protective effects of IE-HBO are related to Prdx6. Mice were exposed to 280 kPa O2 for 60 min, followed by 30-min exposure to 20% O2/N2 mixture with equal pressure,...
Medicine by Alexandros G. Sfakianakis
07:06
Thyroxin and calcitonin secretion into thyroid venous blood is regulated by pharyngeal mechanical stimulation
 in anesthetized ratsAbstractThe effects of the pharyngeal non-noxious mechanical stimulation on the secretion of immunoreactive thyroxin (iT4), immunoreactive calcitonin (iCT), and immunoreactive parathyroid hormone (iPTH) into thyroid venous blood were examined in anesthetized rats. Secretion rates of iT4, iCT, and iPTH were calculated from their concentration in thyroid venous plasma and the plasma flow rate. A mechanical stimulation was delivered to the pharynx by a rubber balloon placed on the...
Medicine by Alexandros G. Sfakianakis
07:06
Assessment of the molluscicidal impact of extracted chlorophyllin on some biochemical parameters in...
Assessment of the molluscicidal impact of extracted chlorophyllin on some biochemical parameters in the nervous tissue and histological changes in Biomphalaria alexandrina and Lymnaea natalensis snailsAbstractBiomphalaria alexandrina and Lymnaea natalensis snails are the intermediate hosts of schistosomiasis and fasciolosis. The aim of the present study is to evaluate the molluscicidal activity of chlorophyll extract as a photodynamic substance against these snails and how it affected its tissues...
Medicine by Alexandros G. Sfakianakis
07:05
Physiological Sciences
Thyroxin and calcitonin secretion into thyroid venous blood is regulated by pharyngeal mechanical stimulation in anesthetized ratsAbstractThe effects of the pharyngeal non-noxious mechanical stimulation on the secretion of immunoreactive thyroxin (iT4), immunoreactive calcitonin (iCT), and immunoreactive parathyroid hormone (iPTH) into thyroid venous blood were examined in anesthetized rats. Secretion rates of iT4, iCT, and iPTH were calculated from their concentration in thyroid venous plasma and...
Medicine by Alexandros G. Sfakianakis
07:04
Cardiology
Electrical Storm: Current Evidence, Clinical Implications, and Future PerspectivesAbstractPurpose of ReviewElectrical storm (ES) is a life-threatening medical emergency of repetitive episodes of sustained ventricular arrhythmias within a short period. Its occurrence is associated with poor short- and long-term survival, even in patients with implantable cardioverter defibrillators (ICD). Management of ES is challenging and mainly based on retrospective studies. This article reviews the existing literature...
Medicine by Alexandros G. Sfakianakis
07:03
Gastroenterology
Recurrence of hepatocellular carcinoma at the porta-hepatis following liver transplantation diagnosed on EUS-FNAAbstractHepatocellular carcinoma (HCC) is a potentially fatal complication of chronic liver disease. Liver transplantation is now the preferred treatment due to good outcomes. We present a unique case of recurrence of HCC at the porta hepatis four years after orthotopic liver transplantation diagnosed via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). Our report also highlights...
Medicine by Alexandros G. Sfakianakis
07:02
Cutaneotrichosporon (Trichosporon) debeurmannianum associated with a subcutaneous mycotic cyst successfully...
Cutaneotrichosporon (Trichosporon) debeurmannianum associated with a subcutaneous mycotic cyst successfully treated with voriconazole M. L. Noy  A. Abdolrasouli  A. M. Borman  M. Fraser  N. Francis  L. S. P. Moore  E. E. MerikaFirst published: 22 July 2019 https://doi.org/10.1111/ced.14037
Medicine by Alexandros G. Sfakianakis
07:00
Concomitant GNA11 and SF3B1 mutations in two cases of melanoma associated with blue naevus , M. Danset ...
Concomitant GNA11 and SF3B1 mutations in two cases of melanoma associated with blue naevus, M. Danset  S. Milley  O. Harou  D. Vasseur  M. Amini‐Adle  L. Thomas  S. Dalle  B. Balme  J. LopezFirst published: 23 July 2019 https://doi.org/10.1111/ced.14036
Medicine by Alexandros G. Sfakianakis
07:00
Small papular pseudolymphoma induced by a patch test for gold, T. Kiyohara, H Tanimura, K. Makimura, S....
Small papular pseudolymphoma induced by a patch test for gold, T. Kiyohara, H Tanimura, K. Makimura, S. Shimada, S. Ohnishi, M. Miyamoto, T. Shijimaya, N. Ma, H. OkamotoFirst Published: 27 July 2019Small papular pseudolymphoma (SPP)1 is characterized by multiple angiomatous papules, mainly on the acral sites of the hands and feet in children. It was first reported as acral pseudolymphomatous angiokeratoma of children (APACHE). The disorder may be recognized as a pseudolymphoma rather than a vascular...
Medicine by Alexandros G. Sfakianakis
06:59

Hypertension

Association between invasively measured aortic pulse pressure and orthostatic hypotension in patients undergoing invasive coronary angiography
Objective: Underlying pathophysiology of orthostatic hypotension has been poorly understood. We hypothesized that aortic pulse pressure (APP) reflecting aortic stiffness may be involved in the development of orthostatic hypotension. Methods: A total of 200 patients (age 64.3 ± 10.9 years, 62.5% men) who underwent invasive coronary angiography (ICA) were prospectively recruited. Orthostatic hypotension was defined as SBP drop at least 20 mmHg or DBP drop at least 10 mmHg within 3 min of the standing position compared with the supine position. Hemodynamic parameters were measured at the ascending aorta using a pig-tail catheter immediately before ICA. APP was calculated as a difference between the aortic peak systolic pressure and the end-diastolic pressure. Results: A total of 156 patients (78.0%) had obstructive coronary artery disease on ICA. Orthostatic hypotension was present in 58 patients (29.0%). Diabetes mellitus was more prevalent in patients with orthostatic hypotension than those without (48.3 vs. 23.2%; P < 0.001). Other clinical parameters including age, cardiovascular risk factors, laboratory findings and concomitant medications were not different between patients with and without orthostatic hypotension (P > 0.05 for each). In hemodynamic parameters, APP was higher in patients with orthostatic hypotension than those without (78.4 ± 25.8 vs. 68.3 ± 21.3 mmHg; P = 0.005). Higher APP was significantly associated with the presence of orthostatic hypotension even after controlling for potential confounders (odds ratio, 2.99; 95% confidence interval 1.15–7.78; P = 0.025). Conclusion: In patients undergoing ICA, APP was associated with increased risk of orthostatic hypotension. Central aortic stiffness may play a role in the development of orthostatic hypotension. Correspondence to Myung-A Kim, MD, PhD, Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Boramae Medical Center, 20, Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Republic of Korea. Tel: +82 2 870 2213; fax: +82 2 870 3866; e-mail: kma@snu.ac.kr Received 5 November, 2018 Revised 26 February, 2019 Accepted 12 March, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

β2AR-dependent signaling contributes to in-vivo reendothelialization capacity of endothelial progenitor cells by shear stress
Background: Endothelial progenitor cells (EPCs) play a crucial role in the endothelial repair after arterial injury. Shear stress has a beneficial effect on modulating EPC functions. The molecular mechanism underlying the influence of EPCs on the endothelial integrity and shear stress effects on EPC regulation remained unclear. Herein, we investigated the influence of β2 adrenergic receptor (β2AR)-dependent signaling on in-vitro shear stress-mediated function and in-vivo reendothelialization capacity of human EPCs. Method: The human EPCs from healthy population were exposed to in-vitro 5, 10, and 20 dyn/cm2 shear stress for 15 h, and 10 dyn/cm2 for 5, 10, and 15 h, respectively. The in-vitro proliferation was assessed by CCK8 and BrDU tests. The migration and adhesion were evaluated by Transwell system and human umbilical vein endothelial cells (HUVECs) incorporation assays. Meanwhile, the angiogenic cytokine stromal derived factor-1 (SDF-1) and vascular endothelial growth factor (VEGF) concentration of supernatant were tested by ELISA. Phosphorylated β2AR, Akt, and eNOS were detected by western blot. In an in-vivo study, mice carotid injury models were produced through denuding the endothelium with a curved flexible wire, and thereafter CM-Dil-labeled EPCs were injected intravenously. After 3 days, cells recruited to the injury sites were detected by fluorescent microscopy, and the in-vivo reendothelialization capacity was assessed by Evans blue dye. Results: Shear stress improved in-vitro functions and in-vivo reendothelialization capacity of human EPCs. In parallel, shear stress up-regulated the phosphorylation of β2AR, Akt, and eNOS, and promoted vascular endothelial growth factor (VEGF) secretion of human EPCs. With ICI118,551 (a β2AR inhibitor) treatment, shear stress-induced Akt and eNOS phosphorylation as well as VEGF secretion were suppressed. After β2AR/PI3K/Akt/eNOS pathway of EPCs was blocked, the effects of shear stress on in-vitro functions and in-vivo reendothelialization capacity of EPCs were inhibited. Conclusion: The present study provided the novel data that shear stress-induced β2AR/Akt/eNOS pathway enhanced reendothelialization capacity of EPCs. Shear stress-induced β2AR-dependent pathway may be a novel and important therapeutic target for endothelial repair. Correspondence to Changnong Peng, Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen & Shenzhen Sun Yat-sen Cardiovascular Hospital, Shenzhen 518057, China, E-mail pengchangnong1965@163.com. Received 5 January, 2019 Revised 20 June, 2019 Accepted 3 July, 2019 Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com). Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Plasminogen activator inhibitor-1 activity and the 4G/5G polymorphism are prospectively associated with blood pressure and hypertension status
Objectives: Plasminogen activator inhibitor-1 (PAI-1) has consistently shown positive associations with blood pressure (BP). Whether elevations in PAI-1 levels precede or result from raised BP is still under debate and data on prospective studies are limited. Hence, we investigated the prospective associations of PAI-1 and the 4G/5G polymorphism with brachial and central BP and pulse pressure (PP) over a 10-year period. Methods: Black South Africans aged 30 years and older were included. Baseline data collection commenced in 2005 (n = 2010) with follow-up data collection in 2010 (n = 1288) and 2015 (n = 926). Plasma PAI-1 activity (PAI-1act), 4G/5G polymorphism genotyping, waist circumference and BP measurements were performed and analysed using sequential regression and mixed models. Results: In multivariable adjusted analyses, PAI-1act and the 4G/4G (vs. the 5G/5G) genotype increased the odds of developing hypertension in the total group [1.04 (1.01; 1.08) and 1.82 (1.07; 3.12) respectively]. Furthermore, PAI-1act was prospectively associated with brachial SBP (r = 0.0815) and PP (r = 0.0832) in the total group, and with central PP in women (r = 0.1125; all P < 0.05). Addition of waist circumference to the models either decreased or nullified the contribution of PAI-1act to BP and hypertension development. Conclusion: PAI-1act and the 4G/4G (vs. the 5G/5G) genotype increased the odds of developing hypertension. Furthermore, PAI-1act associated prospectively with both brachial and central BP. These associations were mediated in part by central adiposity. The study supports the hypothesis that PAI-1 also contributes to hypertension development rather than solely being a consequence thereof. Correspondence to Professor Aletta E. Schutte, Hypertension in Africa Research Team, North-West University, Private Bag X1290, Potchefstroom 2520, South Africa. Tel: +27 (0)18 299 2444; fax: +27 (0)18 285 2432; e-mail: Alta.Schutte@nwu.ac.za Received 1 March, 2019 Revised 31 May, 2019 Accepted 3 July, 2019 Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com). Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Collagen biomarkers are associated with decline in renal function independently of blood pressure and other cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis Study
Objective: We studied associations of circulating collagen type I carboxy-terminal telopeptide (ICTP) and procollagen type III N-terminal propeptide (PIIINP) with long-term renal function decline. Methods: In the Multi-Ethnic Study of Atherosclerosis, we included 2492 participants initially aged 45–84 years and free of clinical cardiovascular disease (CVD), excluding people with estimated glomerular filtration rate (eGFR) less than 60 ml/min per 1.73 m2 or urine albumin/creatinine (UAC) at least 30 mg/g. The primary outcome in median 9.4-year follow-up was renal function decline (≥30% decline in eGFR between any two exams or incident UAC ≥ 30 mg/g). The associations of baseline plasma ICTP and PIIINP with renal function decline were estimated using Poisson regression, adjusting for baseline variables race/ethnicity, sex, age, and continuous eGFR and UAC, with further adjustment for CVD risk factors and medications. Results: Baseline serum ICTP was 3.27 ± 1.43 μg/l and PIIINP was 5.43 ± 1.85 μg/l. Mean baseline eGFR was 91.5 ± 18.4 ml/min per 1.73 m2. Renal function decline occurred in 19.5% during 9.4-year follow-up. The renal function decline outcome was positively associated with serum ICTP and PIIINP: relative incidence density (95% confidence interval) per SD 1.22 (1.11–1.33) and 1.27 (1.16–1.40), respectively. Additional adjustment for other risk factors did not greatly alter findings. Conclusion: High collagen biomarker concentrations in serum were associated with future decline in renal function in people initially free of CVD and with normal eGFR, consistent with collagen production signaling renal decline. The continuous association observed for ICTP which, unlike PIIINP, is filtered by the kidney, may owe to its double status as a sensitive marker of glomerular function and collagen degradation. Correspondence to Daniel A. Duprez, MD, PhD, Cardiovascular Division Medical School, University of Minnesota, 420 Delaware St SE, MMC 508, Minneapolis, MN 55455, USA. Tel: +1 612 624 4948; fax: +1 612 626 4411; e-mail: dupre007@umn.edu Received 24 March, 2019 Revised 22 June, 2019 Accepted 9 July, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Association between dietary carotenoid intakes and hypertension in adults: National Health and Nutrition Examination Survey 2007–2014
Objective: Few epidemiological studies concentrated on dietary carotenoids and hypertension since new hypertension guideline released in 2017. Thus, this study was aimed to evaluate their association. Methods: Data from National Health and Nutrition Examination Survey (NHANES) 2007–2014 were used in this cross-sectional study. Dietary carotenoids data were obtained from 24-h dietary recall interviews. Hypertension was defined as SBP at least 130 mmHg or DBP at least 80 mmHg, taking antihypertensive medicine or self-report. Logistic regression models and restricted cubic spline models were applied to explore the associations between α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein with zeaxanthin, and total carotenoids from diet and supplements and hypertension. Total carotenoids showed significant reductive risk of hypertension at 100 μg/kg per day and over. Results: A total of 17 398 adults aged 20 years and over were identified. High dose of β-carotene, lycopene, lutein with zeaxanthin, and total carotenoids were significantly associated with decreased risk of hypertension in crude results. After multivariate-adjustment in model 2, the odds ratios (OR) with 95% confidence intervals (CI) of β-cryptoxanthin, lycopene, lutein with zeaxanthin and total carotenoids for hypertension were 0.79 (0.67–0.93), 0.85 (0.73–0.98), 0.69 (0.58–0.83), 0.73 (0.62–0.86) for the highest versus lowest quartile intakes, respectively. Dose–response analyses showed that all of the carotenoids were inversely associated with hypertension in a linear manner. Total carotenoids showed significant effect of lower risk of hypertension at 100 μg/kg per day. Conclusion: Intakes of α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein with zeaxanthin, and total carotenoids were inversely associated with hypertension in US adults. The intake of total carotenoids was suggested at least 100 μg/kg per day for general adult population. Correspondence to Dongfeng Zhang, Department of Epidemiology and health Statistics, The College of Public Health of Qingdao University, No. 38 Dengzhou Road, Qingdao 266021, China. Tel: +86 53282991712; fax: +86 53283801449; e-mail: zhangdf1961@126.com,zhangdf1962@aliyun.com Received 17 May, 2019 Revised 3 July, 2019 Accepted 3 July, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Highlights of the September issue
No abstract available

Feasibility of 24-h central blood pressure monitoring: experience from multinational clinical trial assessing the efficacy of perindopril/indapamide/amlodipine
Objectives: Brachial blood pressure (BP) is a predictor of cardiovascular events. Evidence suggests that central BP (CBP) provides additional information for cardiovascular risk assessment. Methods to assess 24-h CBP are now available. Our objective was to assess the feasibility of 24-h CBP monitoring in clinical trials and its ability for drug evaluation. Methods: Data are issued from an international phase 3 randomized clinical trial comparing the efficacy of perindopril/indapamide/amlodipine vs. perindopril/indapamide (Per/Ind), in uncontrolled hypertensive patients treated with Per/Ind. 24-h ambulatory BP monitoring (ABPM) was performed at baseline and after 1-month treatment using the Mobil-O-Graph device which provide brachial BP and CBP and arterial parameters. Results: From the 345 patients included in the ABPM substudy, 276 had two valid ABPM (M0 and M1) for brachial BP assessment (80%). After applying device/software built-in and expert quality control criteria on these recordings, 210 (76%) had valid data at M0 and M1 for the assessment of CBP. After 1 month, superior ambulatory central SBP reductions were observed in the perindopril/indapamide/amlodipine (n = 101) vs. Per/Ind group (n = 109) for 24-h/daytime/night-time periods (−4.5 mmHg, P = 0.002/−5.0, P < 0001/−4.1 mmHg, P = 0.016, respectively). Similar trends were observed for pulse wave velocity and other central parameters. Conclusion: Recording 24-h central ABPM and its derived arterial parameters needs a strict expert quality control and must consider a loss of up to 39% of the population included in the ABPM substudy. This method can be used to assess drug effect. Correspondence to Dr Jirar Topouchian, MD, Paris-Descartes University, AP-HP, Diagnosis and Therapeutic Center, Hôtel-Dieu, 1 rue de la Cité, 75181 Paris, France. Tel: +33 0 620102109; e-mail: jtopouchian@jtcrc.com Received 29 January, 2019 Revised 14 June, 2019 Accepted 1 July, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Aspirin enhances trophoblast invasion and represses soluble fms-like tyrosine kinase 1 production: a putative mechanism for preventing preeclampsia
Objective: Recent studies suggested that prophylactic aspirin prior to 16 weeks of gestation in high-risk patients may reduce the risk of developing preeclampsia; however, the exact mechanism of aspirin's effect on the pathophysiology of preeclampsia is not clear. This study was designed to investigate the effect of aspirin on trophoblast cell function and its effect on soluble fms-like tyrosine kinase 1 (sFlt-1) production to elucidate the preventive mechanisms for preeclampsia. Methods and results: We used two human trophoblastic cell lines (HTR-8/SVneo and JAR) and freshly isolated cytotrophoblasts from normal and preeclamptic placenta at term to determine the effect of aspirin on trophoblast cell function. Trophoblasts were pretreated with aspirin, and then cell functions and sFlt-1 expression were assessed. Our results showed that aspirin promoted trophoblast invasion not only in HTR-8/SVneo and JAR cells, but also in isolated cytotrophoblasts. sFlt-1 production was repressed by aspirin in a dose-dependent manner. By adding Flt-1 recombinant protein, the trophoblast invasion ability was inhibited in HTR-8/SVneo cells, which was reversed by Flt-1 small interfering ribonucleic acid knockdown. In addition, metalloproteinase 2/9 expression and activity were activated by aspirin but inhibited by sFlt-1. Aspirin also downregulated Akt phosphorylation, and trophoblast invasiveness was facilitated under Akt inhibitor treatment. Conclusion: Aspirin enhances cell invasiveness and inhibits sFlt-1 production in trophoblasts. Moreover, sFlt-1 itself also inhibits trophoblast invasion. Our novel findings suggest that the preeclampsia prevention effect of aspirin may be exerted through these two mechanisms. Correspondence to Mei-Tsz Su, MD, PhD, Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 704, Taiwan. Fax: +886 6 276 6185; e-mail: sumeitsz@mail.ncku.edu.tw Received 16 October, 2018 Revised 19 April, 2019 Accepted 8 June, 2019 Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com). Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Linear periodization of strength training in blocks attenuates hypertension and diastolic dysfunction with normalization of myocardial collagen content in spontaneously hypertensive rats
Background and method: This study evaluated the effects of a linear block strength training programme on the parameters of cardiac remodelling in spontaneously hypertensive rats. Thirty-nine rats were equally distributed in four groups: normotensive sedentary (N), normotensive trained, hypertensive sedentary (H) and hypertensive trained. The strength training protocol was organized in three mesocycles of 4 weeks, with an increase in the training load organized in a linear fashion for each block, considering the weight established in the maximum loaded load test. The following parameters were evaluated: ventricular function assessed by echocardiogram, caudal blood pressure, ventricular haemodynamics and cardiac masses. Two-way analysis of variance was used to determine the differences between the group and time. Results: After 12 weeks of training, the hypertensive trained group presented the following results: increased muscle strength, reduced blood pressure, reduced heart rate, isovolumetric relaxation time and total collagen content, with increased cardiac function, without promoting changes in the mass and nuclear volume of cardiomyocytes. Also, blood pressure reduction seems to be associated with both muscle strength adjustments and total load progress. Conclusion: The findings of this study showed that the training programme carried out attenuated systemic arterial pressure and preserved the ventricular function of spontaneously hypertensive rats without cardiac mass change. Correspondence to Danilo S. Bocalini, PhD, Experimental Physiology and Biochemistry Laboratory, Physical Education and Sports Center of the Federal University of Espirito Santo, Rua Ludwik Macal, 403, apto 101, Jardim da Penha, Vitoria, Espirito Santo 29060-030, Brazil; E-mail: bocaliniht@hotmail.com Received 23 January, 2019 Revised 8 June, 2019 Accepted 10 June, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Prehypertension and risk of cardiovascular diseases: a meta-analysis of 47 cohort studies
Objective: To assess the association of prehypertension (SBP 120–139 mmHg and/or DBP 80–89 mmHg) and total cardiovascular diseases (CVDs), coronary heart disease (CHD), myocardial infarction (MI), and stroke. Methods: PubMed, Embase, and Web of Science were searched for articles published up to 7 November 2018. Normal range BP was considered SBP less than 120 mmHg and DBP less than 80 mmHg. RRs and 95% CIs were pooled using fixed-effects models. Meta-regression was conducted to estimate the heterogeneity among subgroups. Results: We included 27 articles (47 studies including 491 666 study participants) in the analysis. Prehypertension was associated with total CVDs (RR 1.40, 95% CI 1.34–1.46), CHD (1.40, 1.28–1.52), MI (1.86, 1.50–2.32), and stroke (1.66, 1.56–1.76). Risk of total CVDs, MI, and stroke was increased with low-range prehypertension (low-range: SBP 120–129 mmHg and/or DBP 80–84 mmHg) versus normal BP – RR 1.42 (95% CI 1.29–1.55), 1.43 (1.10–1.86), and 1.52 (1.27–1.81), respectively – and risk of total CVDs, CHD, MI, and stroke was increased with high-range prehypertension (high-range: SBP 130–139 mmHg and/or DBP 85–89 mmHg) – RR 1.81 (95% CI 1.56–2.10), 1.65 (1.13–2.39), 1.99 (1.59–2.50), and 1.99 (1.68–2.36), respectively. The population-attributable risk for the association of total CVDs, CHD, MI, and stroke with prehypertension was 12.09, 13.26, 24.60, and 19.15%, respectively. Conclusion: Prehypertension, particularly high-range, is associated with increased risk of total CVDs, CHD, MI, and stroke. Effective control of prehypertension could prevent more than 10% of CVD cases. Correspondence to Dongsheng Hu, 100 Kexue Avenue, Gaoxin District, Zhengzhou, Henan, China. Tel: +86 755 86671951; fax: +86 755 86671906; e-mail: dongsheng_hu@zzu.edu.cn Received 25 February, 2019 Revised 22 May, 2019 Accepted 13 June, 2019 Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://www.jhypertension.com). Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Alexandros Sfakianakis
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