Chronic administration of pharmacological doses of angiotensin 1-7 and iodoangiotensin 1-7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats

xlomafota13 shared this article with you from Inoreader Chronic administration of pharmacological doses of angiotensin 1-7 and iodoangiotensin 1-7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats Via radioactive iodine Physiol Rep. 2021 Apr;9(7):e14812. doi: 10.14814/phy2.14812. ABSTRACT Cardiovascular diseases are the principal cause of death worldwide, with hypertension being the most common cardiovascular disease risk factor. High blood pressure (BP) is also associated with an increased risk of poor cognitive performance and dementia including Alzheimer's disease. Angiotensin 1-7 (Ang 1-7), a product of the renin-angiotensin system (RAS), exhibits central and peripheral actions to reduce BP. R ecent data from our lab reveals that the addition of a non-radioactive iodine molecule to the tyrosine in position 4 of Ang 1-7 (iodoAng 1-7) makes it ~1000-fold more potent than Ang 1-7 in competing for the 125 I-Ang 1-7 binding site (Stoyell-Conti et al., 2020). Moreover, the addition of the non-radioactive iodine molecule increases (~4-fold) iodoAng 1-7's ability to bind to the AT1 receptor (AT1R), the primary receptor for Ang II. Preliminary data indicates that iodoAng 1-7 can also compete for the 125 I-Ang IV binding site with a low micromolar IC50. Thus, our aims were to compare the effects of chronic treatment of the Spontaneously Hypertensive Rat (SHR) with iodoAng 1-7 (non-radioactive iodine isotope) and Ang 1-7 on arterial pressure, heart rate, and cognitive function. For this study, male SHRs were divided into three groups and treated with Saline, Ang 1-7, or iodoAng 1-7 administrated subcutaneously using a 28-day osmotic mini pump. Systolic BP was m easured non-invasively by the tail-cuff technique. Cognitive function was assessed by Y-Maze test and novel object recognition (NOR) test. We have demonstrated in SHRs that subcutaneous administration of high doses of iodoAng 1-7 prevented the increase in heart rate with age, while Ang 1-7 showed a trend toward preventing the increase in heart rate, possibly by improving baroreflex control of the heart. Conversely, neither Ang 1-7 nor iodoAng 1-7 administered subcutaneously affected BP nor cognitive function. PMID:33904655 | DOI:10.14814/phy2.14812 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Increasing prediction accuracy of pathogenic staging by sample augmentation with a GAN

xlomafota13 shared this article with you from Inoreader Increasing prediction accuracy of pathogenic staging by sample augmentation with a GAN Via Head and neck cancers by ChangHyuk Kwon, Sangjin Park, Soohyun Ko, Jaegyoon Ahn Accurate prediction of cancer stage is important in that it enables more appropriate treatment for patients with cancer. Many measures or methods have been proposed for more accurate prediction of cancer stage, but recently, machine learning, especially deep learning-based methods have been receiving increasing attention, mostly owing to their good prediction accuracy in many applications. Machine learning methods can be applied to high throughput DNA mutation or RNA expression data to predict cancer stage. However, because the number of genes or markers generally exceeds 10,000, a considerable number of data samples is required to guarantee high prediction accuracy. To solve this problem of a small number of clinical samples, we used a Generative Adversarial Networks (GANs) to augment the samples. Because GANs are not effective with whole genes, we first selected significant genes using DNA mutation data and random forest feature ranking. Next, RNA expression data for selected genes were expanded using GANs. We compared the classification accuracies using original dataset and expanded datasets generated by proposed and existing methods, using random forest, Deep Neural Networks (DNNs), and 1-Dimensional Convolutional Neural Networks (1DCNN). When using the 1DCNN, the F1 score of GAN5 (a 5-fold increase in data) was improved by 39% in relation to the original data. Moreover, the results using only 30% of the data were better than those using all of the data. Our attempt is the first to use GAN for augmentation using numeric data for both DNA and RNA. The augmented datasets obtained using the proposed method demonstrated significantly increased classification accuracy for most cases. By using GAN and 1DCNN in the prediction of cancer stage, we confirmed that good results can be obtained even with small amounts of samples, and it is expected that a great deal of the cost and time required to obtain clinical samples will be reduced. The proposed sample augmentatio n method could also be applied for other purposes, such as prognostic prediction or cancer classification. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Die Behandlung von Schilddrüsenmalignomen aus HNO-ärztlicher Sicht

xlomafota13 shared this article with you from Inoreader Die Behandlung von Schilddrüsenmalignomen aus HNO-ärztlicher Sicht Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1475-4939 Einleitung Die Zahl der Schilddrüsenmalignome zeigt eine deutliche Zunahme. Da die Schilddrüse an der HNO-Klinik Bad Hersfeld im Fokus steht, war dies für uns Anlass, unsere Behandlungsresultate zu untersuchen und Erfahrungen darzustellen. Material und Methoden Es handelt sich um eine Untersuchung beginnend im Jahre 2014 bis zum Juli 2020. Es wurden alle Patienten mit Schilddrüsenmalignomen erfasst und wichtige demografische und medizinische Parameter wie Alter, Geschlecht, Histologie, Calcium, OP-Dauer, Rekurrensparese etc. registriert. Ergebnisse Es wurden insgesamt 63 Patienten mit malignen Schilddrüsenerkrankungen eingeschlossen. Davon waren 42 weiblichen und 21 männlichen Geschlechts. Die Altersspanne reichte von 11 bis zu 95 Jahren. Patienten mit differenzierten Schilddrüsenkarzinomen waren im Schnitt jünger als diejenigen mit anaplastischen Malignomen. Histologisch dominierten die papillären Schilddrüsenkarzinome mit 65 % (n = 41) gegenüber anderen Varianten wie dem follikulären (n = 6), medullären (n = 5) und entdifferenzierten Karzinom (n = 6). Alle Patienten wurden einer operativen Behandlung unterzogen; postoperativ erhielten die Betroffenen mit fortgeschrittenen, differenzierten Karzinomen eine Radiojodtherapie. Von den Patienten mit einem entdifferenzierten Karzinom sind alle ihrem Leiden erlegen, während nach unserer Kenntnis nur eine Betroffene mit einem differenzierten Malignom tumorbedingt verstorben ist. Schlussfolgerung In die Behandlung von malignen Schilddrüsenerkrankungen ist der HNO-Arzt eingebunden. Wie bei den benignen Erkrankungen der endokrinen Halsorgane ist eine interdisziplinäre Zusammenarbeit entscheidend. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Dermatomyositis als paraneoplastisches Syndrom bei Kopf-Hals-Malignomen: Fallserie & Literaturreview

xlomafota13 shared this article with you from Inoreader Dermatomyositis als paraneoplastisches Syndrom bei Kopf-Hals-Malignomen: Fallserie & Literaturreview Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1408-6551 Einleitung/Ziel Die Dermatomyositis (DM) ist eine seltene Erkrankung, die sich klinisch durch Schwäche und Schmerzen proximaler Muskeln sowie fliederfarbene Hautveränderungen manifestiert. In fast einem Fünftel der Fälle ist die DM mit dem Auftreten von Tumorerkrankungen assoziiert. Ziel dieser Untersuchung ist die Bewertung der Bedeutung der DM als paraneoplastisches Syndrom bei Malignomen im Kopf-Hals-Bereich unter Berücksichtigung der aktuellen Literatur. Material/Methoden Nach retrospektiver Krankenaktenanalyse der Jahre 2008–2018 von Patienten mit Kopf-Hals-Malignomen fanden sich 8 Patienten mit einer Dermatomyositis: 4 Patienten mit Tonsillenkarzinom, 1 Patient mit Nasopharynxkarzinom, 1 Patient mit Parotiskarzinom und 2 Patienten mit Lymphomen. Es wurden die Diagnostik, Therapie und Behandlungsergebnisse der Fälle beschrieben. Zudem erfolgte eine selektive Analyse der Literatur (PubMed) zur DM bei HNO-Tumoren. Bei dieser fanden sich insgesamt 290 Fälle: die Malignome waren in 283 Fällen im Nasopharynx, in 5 Fällen in der Tonsille und in 2 Fällen im Hypopharynx lokalisiert. Ergebnisse/Schlussfolgerung Eine DM als paraneoplastisches Syndrom bei Kopf-Hals-Malignomen ist selten. Sie tritt häufiger in Assoziation mit Nasopharynxkarzinomen und selten bei Tonsillenkarzinomen auf.Das gehäufte Auftreten der DM bei Kopf-Hals-Malignomen in Abhängigkeit von der ethnischen Verteilung (Nasopharynxkarzinome – asiatische Abstammung, Tonsillenkarzinom – kaukasische Abstammung) ist möglicherweise auch auf regionale Inzidenzunterschiede der genannten Tumorentitäten zurückzuführen.Bei Patienten mit einer DM sollte ein Tumorausschluss auch im Kopf-Hals-Bereich erfolgen, insbesondere bei Vorliegen einer zervikalen Lymphadenopathie. Der Verlauf einer tumorassoziierten DM wird durch die Tumortherapie positiv beeinflusst. Therapeutisch ist aber auch eine konsequente Behandlung der DM die Grundlage für eine erfolgreiche Tumortherapie. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Revision canal-wall down surgery: comparison of surgical outcomes with three different techniques

xlomafota13 shared this article with you from Inoreader Revision canal-wall down surgery: comparison of surgical outcomes with three different techniques Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Apr 27. doi: 10.1007/s00405-021-06829-y. Online ahead of print. ABSTRACT OBJECTIVE: This study aimed to analyze the role of the endoscope in revision canal-wall down (CWD) tympanomastoid surgery and compare its use to the more traditional microscopic approach. Moreover, we aim to investigate functional outcomes of revision surgeries in a cohort of two tertiary reference centers. METHODS: A total of 103 patients undergoing revision surgery after previous CWD tympanomastoidectomy were included in the present study and divided in three groups according to the surgical technique used: endoscope exclusive (n = 22), combined (n = 35) and microscope exclusive (n = 46). Data regarding surgical indications, pre-operative clinical and audiological assessments, intraoperative findings and surgical considerations were extracted. During follow-up, data regarding anatomic and audiologic outcomes were collected a nd persistence or recurrence of the disease assessed. RESULTS: The most frequent sites of cholesteatoma recurrence or persistence was the anterior epitympanum. There was a statistically significant ABG improvement of - 6.02 dB HL (95% CI - 8.87 to - 3.16, p < 0.001) between pre-operative and postoperative ABG, without significant effect of surgical technique. During follow-up, no significant differences regarding disease or otorrhea control were observed. Duration of surgery and hospitalization was shorter in the endoscopic cohort without statistical significance. Intra- and postoperative complications were lower in the endoscopic group. CONCLUSION: Revision CWD surgery can take advantage of the endoscope as a minimally invasive exclusive or adjunct tool to traditional microscopic procedures. Outcome measures of endoscopic revision CWD surgery showed anatomic and functional results comparable to those of the microscopic group. The complication rate, the duration of su rgery and hospitalization were favorable in the endoscopic group. PMID:33904981 | DOI:10.1007/s00405-021-06829-y View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Reconstrucción lingual con colgajo libre radial: A propósito de un caso

xlomafota13 shared this article with you from Inoreader Reconstrucción lingual con colgajo libre radial: A propósito de un caso Via Otorrinolaringología y cirugía de cabeza y cuello Resumen El cáncer de lengua es una patología con una importante morbilidad e impacto en la calidad de vida del paciente, afectando la masticación, deglución, comunicación y gusto, por lo que requiere de un equipo multidisciplinario para establecer la rehabilitación adecuada. Se necesita realizar resecciones amplias para asegurar márgenes negativos, y si el cirujano considera que existe un volumen remanente insuficiente para obliterar la cavidad oral, la realización de un colgajo será necesario para mantener la función deglutoria. Se presenta el caso de un paciente de 76 años, masculino, con antecedentes de tabaquismo suspendido hace 23 años, que presenta una lesión ulcerada dolorosa en el borde derecho de la lengua móvil, la biopsia informa un carcinoma epidermoide, etapificado T2N0M0, por lo que se decide realizar hemiglosectomía derecha más disección cervical y reconstrucción con colgajo libre radial. Abstract Tongue cancer is a pathology with significant morbidity and impact on the quality of life of the patients. It affects chewing, swallowing, communication, and taste. Therefore, a multidisciplinary team is required to establish adequate rehabilitation. Extensive resections are needed to ensure negative margins. If the surgeon considers that there is insufficient remaining volume to obliterate the oral cavity, flap surgery will be carried out to maintain the swallowing function. We present a case report of a 76-year-old male patient with a history of smoking cessation of 23 years. He presents a painful ulcerated lesion on the right edge of the mobile tongue. The biopsy reports an epidermoid carcinoma, staged T2N0M0 which led to perform a right hemiglosectomy, cervical dissection, and reconstruction with free radial forearm flap. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Colgajo en isla submental: Experiencia de 2 casos en reconstrucción de base de cráneo lateral

xlomafota13 shared this article with you from Inoreader Colgajo en isla submental: Experiencia de 2 casos en reconstrucción de base de cráneo lateral Via Otorrinolaringología y cirugía de cabeza y cuello Resumen La cirugía reconstructiva de cabeza y cuello es una tarea compleja. Existen varias opciones disponibles para lograr buenos resultados, desde colgajos locales hasta colgajos libres microvascularizados. En este reporte presentamos nuestra experiencia utilizando el colgajo en isla submental para la reconstrucción de defectos de tejido blando de base de cráneo lateral posterior a una resección lateral de hueso temporal secundario a diagnósticos oncológicos otológicos. Se presentan datos demográficos, clínicos, quirúrgicos y resultados de dos pacientes intervenidos durante el primer semestre del año 2020, en los cuales se consiguió un adecuado resultado reconstructivo. Este colgajo es una opción confiable y versátil para reconstrucción en cabeza y cuello. Abstract Reconstructive head and neck surgery is a complex task. There are several options available to achieve good results, from local flaps to free microvascular flaps. In this article, we present our e xperience using the submental island flap for soft tissue defect reconstruction of the lateral skull base after a lateral temporal bone resection secondary to otologic cancer. Demographic, clinical, surgical and outcome data of two patients operated on during the first semester of 2020 are presented, in whom a good reconstructive result was achieved. This flap is a reliable and versatile option for head and neck reconstruction. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.