Cancer Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Πέμπτη 31 Μαρτίου 2016
Weight Regain Following Intentional Weight Loss in Older Adults
Abstract
Weight gain results from an imbalance of dietary intake and energy expenditure, and rates of overweight and obesity remain high in our society. Although weight loss is achievable, most subjects who participate in weight loss studies will regain weight and consequently recidivism remains a problem. The effectiveness of maintenance therapy is a continuing area of investigation as various dietary, behavioral, and physical activity strategies are either being investigated or are recommended. This chapter will also introduce mechanisms proposed for weight regain after intentional weight loss and the influence of weight regain on metabolic risk in adults.
from Cancer via ola Kala on Inoreader http://ift.tt/1UwbwkW
via IFTTT
The Role of Vitamin K in Chronic Aging Diseases: Inflammation, Cardiovascular Disease, and Osteoarthritis
Abstract
Vitamin K is an enzyme cofactor required for the carboxylation of vitamin K-dependent proteins, several of which have been implicated in diseases of aging. Inflammation is recognized as a crucial component of many chronic aging diseases, and evidence suggests vitamin K has an anti-inflammatory action that is independent of its role as an enzyme cofactor. Vitamin K-dependent proteins and inflammation have been implicated in cardiovascular disease and osteoarthritis, which are leading causes of disability and mortality in older adults. The purpose of this review is to summarize observational studies and randomized trials focused on vitamin K status and inflammation, cardiovascular disease, and osteoarthritis. Although mechanistic evidence suggests a protective role for vitamin K in these age-related conditions, the benefit of vitamin K supplementation is controversial because observational data are equivocal and the number of randomized trials is few.
from Cancer via ola Kala on Inoreader http://ift.tt/1ZP0tmn
via IFTTT
The roles of serum PDCD5 in circulating CD133 positive cells of the patients with gastric cancer
Abstract
Cancer stem cells are responsible for the development, metastasis, recurrence, and drug resistance of cancer. More and more studies exhibited that the circulating CD133+ cells is a marker for the prognosis of various malignancies. Programmed cell death protein 5 (PDCD5) can promote apoptosis in different tumor cell types in response to various stimuli. However, the impact of PDCD5 on circulating CD133+ cells of gastric cancer patients remains unclear. In this study, we detected serum PDCD5 level in blood samples of the patients with gastric cancer by using ELISA. MTT assay, sphere assay, and wound healing assay were used to test the anti-tumor effects of rhPDCD5 on CD133+ cells in vitro. Lower serum levels of PDCD5 protein were identified in the gastric cancer patients that with CD133+ fraction more than 1.6 %. No difference between healthy controls and the gastric cancer patients that with CD133+ fraction less than 1.6 %. Serum PDCD5 was correlated with the favorable prognosis of patients with gastric cancer. In the last, we confirmed that rhPDCD5 could induce apoptosis, and inhibit the proliferation, colony formation, and mobility of CD133+ cells in vitro by suppressing MEK/ERK pathway. Serum PDCD5 could be considered as a potential drug for the gastric cancer patients with circulating CD133+ cells.
from Cancer via ola Kala on Inoreader http://ift.tt/1Uw44Gt
via IFTTT
Εγγραφή σε:
Αναρτήσεις (Atom)