Bartonella Neuroretinitis

alkiviadis.1961 shared this article with you from Inoreader Bartonella Neuroretinitis Via Massachusetts Medical Society: New England Journal of Medicine: Table of Contents New England Journal of Medicine, Ahead of Print. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nucleoside‐modified messenger RNA (modRNA) COVID‐19 vaccine platform

alkiviadis.1961 shared this article with you from Inoreader Nucleoside‐modified messenger RNA (modRNA) COVID‐19 vaccine platform Via Journal of Medical Virology SUMMARY: On March 11, 2020, the World Health Organization declared Coronavirus Disease 19 (COVID‐19) a pandemic; from that date the vaccine race has begun, and many technology platforms to develop a specific and effective COVID‐19 vaccine have been launched in several clinical trials (protein subunit, RNA‐based, DNA‐based, replicating viral vector, non‐replicating viral vector, inactivated virus, live attenuated virus and virus‐like particle). Among the next‐generation strategies, nucleoside‐modified messenger RNA (modRNA) vaccines appear the most attractive, not only to counteract emerging pathogens, but also for the possible applications in regenerative medicine and cancer therapy. However, exactly as all innovative drugs, they deserve a careful pharmacovigilance in the short and long term. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The role of teicoplanin in the treatment of SARS‐CoV‐2 infection: a retrospective study in critically ill COVID‐19 patients (Tei‐COVID Study)

alkiviadis.1961 shared this article with you from Inoreader The role of teicoplanin in the treatment of SARS‐CoV‐2 infection: a retrospective study in critically ill COVID‐19 patients (Tei‐COVID Study) Via Journal of Medical Virology ABSTRACT INTRODUCTION Teicoplanin has a potential antiviral activity expressed against SARS‐CoV‐2 and was suggested as a complementary option to treat COVID‐19 patients. In this multicentric, retrospective, observational research the aim was to evaluate the impact of teicoplanin on the course of COVID‐19 in critically ill patients. METHODS 55 patients with severe COVID‐19, hospitalized in the ICUs and treated with best available therapy were retrospectively analysed. Among them 34 patients were also treated with teicoplanin (Tei‐COVID group), while 21 without teicoplanin (control group). RESULTS Crude in‐hospital day‐30 mortality was lower in Tei‐COVID group (35,2%) than in control group (42,8%), however not reaching statistical significance (p = 0.654). No statistically significant differences in length of stay in the ICU were observed between Tei‐COVID group and control group (p = 0.248). On day 14 from the ICU hospitalization, viral clearance was achieved in 64.7% patients of Tei‐COVID group and 57.1% of control group, without statistical difference. Serum C reactive Protein level was significantly reduced in Tei‐COVID group compared to control group, but not other biochemical parameters. Finally, Gram‐positive were the causative pathogens for 25% of BSIs in Tei‐COVID group and for 70,6% in controls. No side effects related to teicoplanin use were observed. CONCLUSION Despite several limitations require further research, in this study the use of teicoplanin is not associated with a significant improvement in outcomes analysed. The antiviral activity of teicoplanin against SARS‐CoV‐2, previously documented, is probably more effective at early clinical stages. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Is obesity a manifestation of systemic racism? A ten‐point strategy for study and intervention

alkiviadis.1961 shared this article with you from Inoreader Is obesity a manifestation of systemic racism? A ten‐point strategy for study and intervention Via Journal of Internal Medicine Abstract In the recent past, there has been rising attention to systemic racism. The ensuing discussions have largely focused on COVID‐19 and policing. Despite long‐standing disparities in obesity across racial and ethnic groups and obesity's important role in COVID‐19 disparities, there has been minimal attention to whether obesity itself could be a manifestation of systemic racism. Nor has there been serious policy attention dedicated to alleviating obesity and its disproportionate burden on BIPOC (Black, Indigenous, and People of Color). We discuss whether obesity's disproportionate harms to BIPOC may be attributed to systemic racism, and we provide a ten‐point strategy for studying and solving the core public health issues at the intersection of obesity and systemic racism. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Systematic literature review of neutralizing antibody immune responses to non-vaccine targeted high-risk HPV types induced by the bivalent and the quadrivalent vaccines

alkiviadis.1961 shared this article with you from Inoreader Systematic literature review of neutralizing antibody immune responses to non-vaccine targeted high-risk HPV types induced by the bivalent and the quadrivalent vaccines Via Vaccine CONCLUSIONS: The cross-protection antibody/immune response among participants having received all three doses of bivalent or quadrivalent vaccine is not comparable to the specific response elicited by HPV vaccine types. Even in cases where a statistically significant cross-reactive immunological response is reported, long-term data on the duration of the response beyond two years are very limited. Further, the lack of a standard for assays limits comparability of results between studies.PMID:33658126 | DOI:10.1016/j.vaccine.2021.01.060 (Source: Vaccine) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Voltammetry of 7-dehydrocholesterol as a new and useful tool for Smith-Lemli-Opitz syndrome diagnosis

alkiviadis.1961 shared this article with you from Inoreader Voltammetry of 7-dehydrocholesterol as a new and useful tool for Smith-Lemli-Opitz syndrome diagnosis Via ScienceDirect Publication: Talanta Publication date: Available online 6 March 2021 Source: Talanta Author(s): Jan Klouda, Lenka Benešová, Pavel Kočovský, Karolina Schwarzová-Pecková View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Non-specific effects of BCG vaccination on neutrophil and lymphocyte counts of healthy neonates from a developed country

alkiviadis.1961 shared this article with you from Inoreader Non-specific effects of BCG vaccination on neutrophil and lymphocyte counts of healthy neonates from a developed country Via ScienceDirect Publication: Vaccine Publication date: Available online 6 March 2021 Source: Vaccine Author(s): Sarah L. Williamson, Eleanor Gadd, Thillagavathie Pillay, Gergely Toldi View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.