Wraparound nylon foil implant for isolated orbital floor fractures

xlomafota13 shared this article with you from Inoreader Wraparound nylon foil implant for isolated orbital floor fractures Via American Journal of Otolaryngology Publication date: Available online 15 September 2021 Source: American Journal of Otolaryngology Author(s): Benjamin C. Campbell, Taha Z. Shipchandler, Jonathan Y.M. Ting, Dominic Vernon, Rana S. Torabi, Manisha Miller, H.B. Harold Lee View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Long-Term Opioid Use in Post-Surgical Management of Patients With Head and Neck Cancer

xlomafota13 shared this article with you from Inoreader Long-Term Opioid Use in Post-Surgical Management of Patients With Head and Neck Cancer Via otol rhinol Ann Otol Rhinol Laryngol. 2021 Sep 14:34894211045771. doi: 10.1177/00034894211045771. Online ahead of print. ABSTRACT OBJECTIVE: This study aims to identify clinical and socioeconomic factors associated with long-term, post-surgical opioid use in the head and neck cancer population. METHODS: A single center retrospective study was conducted including patients diagnosed with head and neck cancer between January 1, 2014 and July 1, 2019 who underwent primary surgical man agement. The primary outcome measure was continued opioid use 6 months after treatment completion. Both demographic and cancer-related variables were recorded to determine what factors were associated with prolonged opioid use. Univariate analysis was performed using chi-squared test for categorical variables and 2-sample t-test for continuous variables. Multivariate analysis was performed using logistic regression. RESULTS: A total of 359 patients received primary surgical management. Forty-five patients (12.53%) continued to take opioids 6 months after treatment completion. Using univariate analysis, patients less than 65 years of age (P = .0126), adjuvant chemoradiation (n = 25, P < .001), and overall length of hospital stay (8.60 ± 8.58 days, P = .0274) were significantly associated with long term opioid use. Multivariate logistic regression showed that adjuvant chemoradiation (OR = 3.446, 95% CI [1.742, 6.820], P = .0004) and overall length of hospital stay (OR = 0.949, 95% CI [0.903, 0.997], P = .0373) to be significantly associated with opioid use 6 months after head and neck cancer treatment. CONCLUSION: Long-term postoperative opioid use in head and neck cancer patients is significantly associated with adjuvant chemoradiation, and patients with longer length of hospital stay. Therefore, future research should focus on interventions to better manage opioid use during the acute treatment period to decrease long-term use. PMID:34521247 | DOI:10.1177/00034894211045771 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Oncogene-specific inhibition in the treatment of advanced pediatric thyroid cancer

xlomafota13 shared this article with you from Inoreader Oncogene-specific inhibition in the treatment of advanced pediatric thyroid cancer Via radioactive iodine J Clin Invest. 2021 Sep 15;131(18):152696. doi: 10.1172/JCI152696. ABSTRACT Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer in the pediatric population and represents the second most common malignancy in adolescent females. Historically, PTC has been classified on the basis of histology, however, accumulating data indicate that molecular subtyping based on somatic oncogenic alterations along with gene expression profiling can better predict c linical behavior and may provide opportunities to incorporate oncogene-specific inhibitory therapy to improve the response to radioactive iodine (RAI). In this issue of the JCI, Y.A. Lee, H. Lee, and colleagues showed that oncogenic fusions were more commonly associated with invasive disease, increased expression of MAPK signaling pathway genes (ERK score), and decreased expression of the sodium-iodine symporter, which was restored by RET- and NTRK-inhibitory therapy. These findings lend credence to the idea of reclassifying pediatric thyroid cancers using a three-tiered system, rather than the two-tiered adult system, and open avenues for the treatment of progressive, RAI-refractory PTC in patients. PMID:34523607 | DOI:10.1172/JCI152696 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort

xlomafota13 shared this article with you from Inoreader Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort Via Journal of Thyroid Research Graves's disease and thyroiditis induce hyperthyroidism, the causes of which remain unclear, although they are involved with genetic and environmental factors. We aimed to evaluate polygenetic variants for hyperthyroidism risk and their interaction with metabolic parameters and nutritional intakes in an urban hospital-based cohort. A genome-wide association study (GWAS) of participants with (cases; n = 842) and without (controls, n = 38,799) hyperthyroidism was used to identify and select genetic variants. In clinical and lifestyle interaction with PRS, 312 participants cured of hyperthyroidism were excluded. Single nucleotide polymorphisms (SNPs) associated with gene-gene interactions were selected by hyperthyroidism generalized multifactor dimensionality reduction. Polygenic risk scor es (PRSs) were generated by summing the numbers of selected SNP risk alleles. The best gene-gene interaction model included tumor-necrosis factor (TNF)_rs1800610, mucin 22 (MUC22)_rs1304322089, tribbles pseudokinase 2 (TRIB2)_rs1881145, cytotoxic T-lymphocyte-associated antigen 4 (CTLA4)_rs231775, lipoma-preferred partner (LPP)_rs6780858, and human leukocyte antigen (HLA)-J_ rs767861647. The PRS of the best model was positively associated with hyperthyroidism risk by 1.939-fold (1.317–2.854) after adjusting for covariates. PRSs interacted with age, metabolic syndrome, and dietary inflammatory index (DII), while hyperthyroidism risk interacted with energy, calcium, seaweed, milk, and coffee intake (). The PRS impact on hyperthyroidism risk was observed in younger ( View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Management of Diabetes Insipidus following Surgery for Pituitary and Suprasellar Tumours

xlomafota13 shared this article with you from Inoreader Management of Diabetes Insipidus following Surgery for Pituitary and Suprasellar Tumours Via leak of cerebrospinal fluid Sultan Qaboos Univ Med J. 2021 Aug;21(3):354-364. doi: 10.18295/squmj.4.2021.010. Epub 2021 Aug 29. ABSTRACT Central diabetes insipidus (CDI) is a common complication after pituitary surgery. However, it is most frequently transient. It is defined by the excretion of an abnormally large volume of dilute urine with increasing serum osmolality. The reported incidence of CDI after pituitary surgery ranges from 0-90%. Large tumour size, gross total resection and intraoperative cerebrospinal fluid leak usually pose an increased risk of CDI as observed with craniopharyngioma and Rathke's cleft cysts. CDI can be associated with high morbidity and mortality if not promptly recognised and treated on time. It is also essential to rule out other causes of postoperative polyuria to avoid unnecessary pharmacotherapy and iatrogenic hyponatremia. Once the diagnosis of CDI is established, close monitoring is required to evaluate the response to treatment and to determine whether the CDI is transient or permanent. This review outlines the evaluation and management of patients with CDI following pituitary and suprasellar tumour surgery to help recognise the diagnosis, consider the differential diagnosis, initiate therapeutic interventions and guide monitoring and long-term management. PMID:34522399 | PMC:PMC8407907 | DOI:10.18295/squmj.4.2021.010 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Early Identification and Management of Congenital Cytomegalovirus

xlomafota13 shared this article with you from Inoreader Early Identification and Management of Congenital Cytomegalovirus Via Otolaryngologic Clinics of North America Congenital cytomegalovirus (cCMV) is the most common nongenetic cause of sensorineural hearing loss. Despite its prevalence, universal screening for cCMV is not currently performed. Hearing loss caused by cCMV is most often severe to profound, often bilateral, and may be fluctuating or progressive. Infants with hearing loss at birth and confirmed cCMV might benefit from antiviral therapy. Roughly half of hearing loss cases owing to cCMV are delayed in onset, and consequently, these children pass newborn hearing screening. Children with cCMV require close audiologic monitoring, require appropriate management with hearing aids, and should be monitored for cochlear implant candidacy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Covid 19 Pandemic-Training of Healthcare Workers in Obtaining a Nasopharyngeal Swab: Our Experience

xlomafota13 shared this article with you from Inoreader Covid 19 Pandemic-Training of Healthcare Workers in Obtaining a Nasopharyngeal Swab: Our Experience Via Otolaryngology Indian Abstract To describe the training of healthcare workers (HCW) in nasopharyngeal swabbing during the COVID 19 pandemic. Study design: Retrospective study. Setting: Tertiary care teaching hospital. Subjects and methods: One hundred and seventy eight health care workers were trained from May 2020 to January 2021. Three modules were designed to train the health care workers in the technique of obtaining a nasopharyngeal swab specimen.Training consisted of an instructional video on how to perform nasopharyngeal swabs and live demonstration followed by hands-on supervised training. The trainees included 30 doctors, 101 nurses, 31 respiratory therapists, 3 physiotherapists, 9 interns and 4 lab technicians. There were 39 male and 139 female trainees. After attending all 3 modules of training, they were confident and efficient in taking a non-traumatic nasopharyngeal swab. Good knowledge and adequate training is key to a good nasopharyngeal sampling for SARS CoV-2 testing. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.