Rosai-Dorfman disease of thymus with elevated serum anti-acetylcholine receptor antibody: a case report

xlomafota13 shared this article with you from Inoreader Rosai-Dorfman disease of thymus with elevated serum anti-acetylcholine receptor antibody: a case report Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Oct 15;14(10):1061-1064. eCollection 2021. ABSTRACT Rosai-Dorfman disease is a rare disorder of histiocytic proliferation in lymph nodes and at extranodal sites. We herein describe a patient with isolated Rosai-Dorfman disease in the thymus with elevated anti-acetylcholine receptor antibody. We examined the relationship between Rosai-Dorfman disease and elevated anti-acetylcholine receptor antibody. To our knowledge, elevated anti-acetylcholine receptor antibody has not been reported in isolated thymic Rosai-Dorfman disease. PMID:34760043 | PMC:PMC8569306 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Expression of immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4), and CD137 in cervical carcinoma

xlomafota13 shared this article with you from Inoreader Expression of immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4), and CD137 in cervical carcinoma Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Oct 15;14(10):1038-1047. eCollection 2021. ABSTRACT Immune checkpoint inhibitors have a significant role in oncology. One of these immune checkpoints is cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Inhibition of the CTLA-4 pathway has already led to the FDA approval of Ipilimumab (anti-CTLA-4), a targeted therapy for melanoma and other malignancies. CD137 is an inducible, costimulatory receptor of the tissue-necrosis-factor-receptor superfamily expressed on the activated immune cells. Clinical trials have also been set for anti-CD137 in several malignancies. We assessed CTLA-4 and CD137 expression on a tissue microarray (TMA) comprising of 99 core tissues which included normal, non-neoplastic, and neoplastic cervical lesions. When detected as strong granular cytoplasmic reaction in the epithelial cells, CTLA-4 expression was scored as positive. For CD137, the results were recorded based on the prese nce or absence of staining reaction on the cell membranes of the lymphoplasmacytic infiltrates. Overall, CTLA-4 was positive in 30% (30/100) of the cervical malignancies. Sub-categorically, 20% of invasive endocervical adenocarcinomas, 63% of adenosquamous carcinomas, and 31% of squamous cell carcinomas were positive for CTLA-4 with a tendency toward lower grade squamous cell carcinomas (SCCs). CD137 was positive in 100% lymphoplasmacytic infiltrates of endocervical adenocarcinomas, 90.5% of SCCs, and 87.5% of adenosquamous carcinomas. This study has found a significant expression of CTLA-4 in cervical cancer cells and CD137 positivity of lymphoplasmacytic infiltrates with potential for future targeted immunotherapy. PMID:34760040 | PMC:PMC8569305 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A machine-learning approach based on 409 treatments to predict optimal number of iodine-125 seeds in low-dose-rate prostate brachytherapy

xlomafota13 shared this article with you from Inoreader A machine-learning approach based on 409 treatments to predict optimal number of iodine-125 seeds in low-dose-rate prostate brachytherapy Via radioactive iodine J Contemp Brachytherapy. 2021 Oct;13(5):541-548. doi: 10.5114/jcb.2021.109789. Epub 2021 Oct 7. ABSTRACT PURPOSE: Low-dose-rate brachytherapy is a key treatment for low-risk or favorable intermediate-risk prostate cancer. The number of radioactive seeds inserted during the procedure depends on prostate volume, and is not easy to predict without pre-planning. Consequently, a large number of unused seeds may be left after treatment. The objective of the present study was to predict t he exact number of seeds for future patients using machine learning and a database of 409 treatments. MATERIAL AND METHODS: Database consisted of 18 dosimetric and efficiency parameters for each of 409 cases. Nine predictive algorithms based on machine-learning were compared in this database, which was divided into training group (80%) and test group (20%). Ten-fold cross-validation was applied to obtain robust statistics. The best algorithm was then used to build an abacus able to predict number of implanted seeds from expected prostate volume only. As an evaluation, the abacus was also applied on an independent series of 38 consecutive patients. RESULTS: The best coefficients of determination R 2 were given by support vector regression, with values attaining 0.928, 0.948, and 0.968 for training set, test set, and whole set, respectively. In terms of predicted seeds in test group, mean square error, median absolute error, mean absolute error, and maxim um error were 2.55, 0.92, 1.21, and 7.29, respectively. The use of obtained abacus in 38 additional patients resulted in saving of 493 seeds (393 vs. 886 remaining seeds). CONCLUSIONS: Machine-learning-based abacus proposed in this study aims at estimating the necessary number of seeds for future patients according to past experience. This new abacus, based on 409 treatments and successfully tested in 38 new patients, is a good alternative to non-specific recommendations. PMID:34759979 | PMC:PMC8565637 | DOI:10.5114/jcb.2021.109789 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An Update on Thyroid Cancer Trials from the European Society of Medical Oncology (ESMO) 2021 Annual Meeting

xlomafota13 shared this article with you from Inoreader An Update on Thyroid Cancer Trials from the European Society of Medical Oncology (ESMO) 2021 Annual Meeting Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 11, Page 500-502, November 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Usefulness of Core Needle Biopsy in the Evaluation of Thyroid Nodules

xlomafota13 shared this article with you from Inoreader The Usefulness of Core Needle Biopsy in the Evaluation of Thyroid Nodules Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 11, Page 487-489, November 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Thyroid Eye Disease Treatment with Intravenous Glucocorticoids Is Improved by the Addition of Atorvastatin

xlomafota13 shared this article with you from Inoreader Thyroid Eye Disease Treatment with Intravenous Glucocorticoids Is Improved by the Addition of Atorvastatin Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 11, Page 474-476, November 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Tumor Volume Doubling Time as a Disease Predictor for Tumor Growth and Lymph Node Metastasis in Papillary Thyroid Microcarcinoma

xlomafota13 shared this article with you from Inoreader Tumor Volume Doubling Time as a Disease Predictor for Tumor Growth and Lymph Node Metastasis in Papillary Thyroid Microcarcinoma Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 11, Page 490-492, November 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.