Antioxidant and Hepatoprotective Activities of Mycelia Selenium Polysaccharide by Hypsizigus marmoreus SK-02

Abstract

This work was designed to investigate the characteristic properties (bond types and monosaccharide compositions), and hepatoprotective effects on carbon tetrachloride (CCl₄)-induced liver damage of mycelia selenium polysaccharides (MSPS) separated and purified from Hypsizigus marmoreus SK-02. Characteristic analysis of MSPS showed the selenium content (70.15 μg/g) in mycelia. The antioxidant activities in vitro demonstrated that MSPS had potential effects on scavenging reactive oxygen species and enhancing the reducing power. The treatment of MSPS for CCl₄-induced animal experiment demonstrated that the MSPS could reduce the levels of malondiadehyde (MDA), lipid peroxide (LPO), glutamic oxalacetic transaminase (AST), and glutamic-pyruvic transaminase (ALT) activities and improve the levels of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), total cholesterol (TC), and triglyceride (TG) in serum/liver homogenate against CCl₄-induced injures. Findings presented in this study clearly demonstrated that MSPS might be suitable for functional foods and natural drugs in preventing the CCl₄-induced acute liver damage.

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