Brain 18 F-FDG, 18 F-Florbetaben PET/CT, 123 I-FP-CIT SPECT and Cardiac 123 I-MIBG Imaging for Diagnosis of a "Cerebral Type" of Lewy Body Disease

Abstract

A 67-year-old man was referred for fluctuating neuropsychiatric symptoms, featuring depression, delirious episodes, recurrent visual hallucinations and catatonic syndrome associated with cognitive decline. No parkinsonism was found clinically even under neuroleptic treatment. ¹⁸F-FDG PET/CT showed hypometabolism in the posterior associative cortex including the occipital cortex, suggesting Lewy body dementia, but ¹²³I-FP-CIT SPECT was normal and cardiac ¹²³I-MIBG imaging showed no signs of sympathetic denervation. Alzheimer's disease was excluded by a normal ¹⁸F-florbetaben PET/CT. This report suggests a rare case of α-synucleinopathy without brainstem involvement, referred to as "cerebral type" of Lewy body disease.

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