Molecular classification of colorectal cancer: Current perspectives and controversies

Publication date: Available online 2 January 2016
Source:Journal of the Egyptian National Cancer Institute
Author(s): Amrallah A. Mohammed, Hani El-Tanni, Hani M. El-Khatib, Ahmad A. Mirza, Amr T. El-Kashif
ObjectiveThe aim of this review is to summarize the molecular classification of colorectal cancer (CRC), recognizing that the review is a small fragment from the whole picture.MethodsA Medline search was conducted and published articles from American and European studies from 2000 to present were reviewed. Different types of molecular classifications are presented.ResultsIntegrative genomic studies revealed the complexity of molecular heterogeneity of CRC. Although several treatments exist, we do not have a good way to select the appropriate treatment; personalized treatment strategies are needed. Genomically-driven clinical trials with matched targeted therapies for KRAS, NRAS, BRAF and PIK3CA mutations are ongoing and offer promising treatment opportunities for patients with CRC.ConclusionFor CRC, a broad molecular classification is "still missing". There is a real hope that the evolving application of molecular techniques to diagnosis, risk-stratification and management of CRC will be translated to reduce disease burden and improve the survival.



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